Senescence and Cell Cycle Control

... Results Probl Cell Differ (42) P. Kaldis: Cell Cycle Regulation DOI 10.1007/001/Published online: 23 November 2005 © Springer-Verlag Berlin Heidelberg 2005 Senescence and Cell Cycle Control Hiroaki ... tumor-suppressor pathways and cell cycle control during cellular senescence. 2 Role of the p53 Pathway in Senescence The tumor-suppressor p53 plays a key role in indu...

Ngày tải lên: 25/10/2013, 21:20

... mechanisms for controlling cell cycle progression (Morgan 1997; Zachariae and Nasmyth 1999). These studies and others demonstrated the universality of the cell Modeling Cell Cycle Control and Cancer ... our understanding of the complexity underlying control of the cell cycle. Control of Cdk activity through cyclin binding and degradation, inhibitory and activating...

Ngày tải lên: 25/10/2013, 21:20

... Brooks Cell Cycle Control Volume 296 Mechanisms and Protocols Edited by Tim Humphrey Gavin Brooks Cell Cycle Control Mechanisms and Protocols The Budding and Fission Yeasts 21 22. Saiz, J. E. and ... Pringle, J. R., and Reid, B. J. (1974) Genetic control of the cell division cycle in yeast. Science 183, 46–51. 12. Lew, D. J., Weinert, T., and Pringle, J. R. (1997...

Ngày tải lên: 08/04/2014, 12:50

... Probl Cell Differ (42) P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136681/Published online: 6 July 2005 © Springer-Verlag Berlin Heidelberg 2005 The ubiquitin-proteasome pathway in cell cycle control ... from studies on the early embryonic cell cycles of Table 1 Cell cycle targets of the anaphase promoting complex Substrate Organism Specificity factor Cell cycle functio...

Ngày tải lên: 25/10/2013, 21:20

... Cellular and Subcellular Transport: Epithe- lial Cells) Edited by SIDNEY FLEISCHER AND BECCA FLE1SCHER VOLUME 192. Biomembranes (Part W: Cellular and Subcellular Transport: Epi- thelial Cells) ... DAVID BARNES AND DAVID A. SIRBASKU VOLUME 148. Plant Cell Membranes Edited by LESTER PACKER AND ROLAND DOUCE VOLUME 149. Drug and Enzyme Targeting (Part B) Edited by RALPH G...

Ngày tải lên: 10/04/2014, 11:13

... cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrest upon growth factor deprivation and ... 2000), cells become immortal but also highly sensitive to apoptosis. 6 Interconnectivity between the pRb and p53 Pathway Although the pRb and p53 pathways in cell cycle con...

Ngày tải lên: 25/10/2013, 21:20

... which is stable throughout the cell cycle and highly resistant to proteolytic degradation [40]. Miscellaneous procedures Yeast were grown on standard media [41] and transformed as described by ... 2007 FEBS phase of the cell- division cycle. Therefore, we tested, using light microscopy and after DAPI staining, whether the slow growth yields a cell- cycle phenotype. Cells of the...

Ngày tải lên: 18/02/2014, 16:20

... upon cell cycle exit. To this effect, HFF cells were deprived of serum f or 48 h to induce cell cycle exit. Serum was th en r e-added a nd samples taken as cells progressed into the cell cycle. ... during the cell cycle [13], upon exit and entry to the cell cycle both genes are controlled, at least in part, transcriptionally. Cdt1 and geminin are highly expressed in pro...

Ngày tải lên: 07/03/2014, 16:20

... cell division cycle; (b) cells treated late in the divi- sion cycle finish the current cycle similar to untreated cells but are significantly delayed in the subsequent division cycle; and (c) cells ... the cell cycle to the control of the RP would be important for drug target identification studies and for under- standing the action mechanism of existing, RP affect- ing drugs....

Ngày tải lên: 15/03/2014, 09:20

... proteins to nucleic acids, and it c ould affect cell g rowth a nd cell cycle duration. The distributing activity of PMLA and the efficiency of competition between PMLA and nucleic acids would both ... PMLA induced a strain specific enhancement of cell growth and an equal (between strains) shortening of the cell cycle. Materials and methods Strains and materials The follo...

Ngày tải lên: 16/03/2014, 18:20