MOLECULAR PHARMACOLOGY, REGULATION AND FUNCTION OF MAMMALIAN MELATONIN

... the siRNA sequence that is most effective in knocking down DLEC1 in HCT116 cell line We then knocked down DLEC1 in the HCT116 cell line using this siRNA 72 hours after the transfection, the cells ... that it was a candidate tumor suppressor gene The over-expression of DLEC1 in hepatocellular carcinoma (HCC) cell lines such as HepG2 and SK-Hep-...

Ngày tải lên: 16/10/2015, 15:37

... [GuillainBarre syndrome: a study of 13 children] An Esp Pediatr 1993, 39:513-516 79 Horiuchi I, Kawano Y, Yamasaki K, Matsuo H, Minohara M, Nakamura T, Hashiguchi H, Ohyagi Y, Yamada T, Kira J: ... deficiency diseases II Serum IgE concentration of patients with acquired hypogammaglobulinemia, thymoma and hypogammaglobulinemia, myotonic dystrophy, intestinal lymphangiectasia and Wi...

Ngày tải lên: 13/08/2014, 13:22

... on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression The pRb Cell Cycle Control Pathway: Components and the Cancer Connection The retinoblastoma protein, ... over-expression of D-type cyclins, mutations rendering Cdk4 The Retinoblastoma Gene Family 185 Fig The p16INK4A -pRb and the p19ARF -p53 pathwa...

Ngày tải lên: 25/10/2013, 21:20

... significance of histone H4 lysine 16 acetylation Active chromatin and DNase I hypersensitive sites Basic features of chromatin structure and the influence of transcription Nucleosomes are the basic building ... permissive for transcription It is generally accepted that active genes lie within broad active chromatin domains that carry a variety of modifications a...

Ngày tải lên: 14/02/2014, 18:20

... PDZ -domain- containing (FRMPD2) [8] and Ras guanine exchange factor (RasGEF) veryKIND (v-KIND, or kinase noncatalytic C-lobe domain containing 1) [9] The KIND domain in these proteins is localized to the ... determined the structural and functional properties of the protein protein interaction between v-KIND and MAP2 We defined the binding core regi...

Ngày tải lên: 14/02/2014, 19:20

... investigate the physiological relevance of Noxo1c expression in the testis, we examined expression of Nox1 and Noxa1 by PCR analysis and found a small but significant amount of the Nox1 and Noxa1 mRNAs ... al Expression and function of Noxo1c A B C Fig Alternative splice forms of human Noxo1 (A) The genomic organization of human NOXO1 gene Translated seque...

Ngày tải lên: 19/02/2014, 06:20

... roles of plant APs References Davies, D.R (1990) The structure and function of the aspartic proteinases Annu Rev Biophys Biophys Chem 19, 189–215 Dunn, B.M (2002) Structure and mechanism of the ... prosegment and total or partial removal of the internal Ó FEBS 2004 Plant aspartic proteinases (Eur J Biochem 271) 2069 Fig Ribbon representation of the crystal st...

Ngày tải lên: 19/02/2014, 12:20

... domain of each subunit contributes to the formation of the hydrophilic pore ACh binding protein has structural and functional homology to the extracellular ligand binding domain of the nAChR, and ... development of selective drugs is the identification and pharmacological characterization of the various receptor subtypes, and the determination of their prec...

Ngày tải lên: 19/02/2014, 12:20

... with the structure of the longer isoform CfAFP-501 using the main chain of residues Thr23fiAsn90 in isoform 337 and residues Thr54fiMet121 in CfAFP-501 (B) Overlap of isoforms 337 and 501 using the ... Ser12fiThr70 in the structure alignment (B) Overlap of the X-ray structure with the 30 °C NMR structure using the main chain of residues Ser12fiThr70 in...

Ngày tải lên: 19/02/2014, 16:20

... C An et al Manduca sexta Spatzle ¨ Introduction A prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function ... gene In the clade including Spatzle- 1, the branch lengths are noticeably longer and ¨ the bootstrap values are lower than in the other clades containing...

Ngày tải lên: 06/03/2014, 09:22

... (2 010 ) 2 611 –2627 ª 2 010 The Authors Journal compilation ª 2 010 FEBS A B Mantsyzov et al 10 11 12 13 14 15 16 17 domain of release factor eRF1 functions in stop codon recognition RNA 6, 12 36 12 47 ... = 10 8 (s )1) Dyy = 10 8 (s )1) Dzz = 10 8 (s )1) s1 = (4Dxx + Dyy + Dzz) )1 (ns) s2 = (Dxx + 4Dyy + Dzz) )1 (ns) s3 = (Dxx + Dyy + 4Dzz) )1 (ns) 0 .10 2 0 .12 5 0...

Ngày tải lên: 06/03/2014, 11:20

... Alphaproteobacteria Proteobacteria, Alphaproteobacteria Proteobacteria, Alphaproteobacteria Proteobacteria, Alphaproteobacteria Proteobacteria, Betaproteobacteria Proteobacteria, Betaproteobacteria Proteobacteria, ... Betaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria...

Ngày tải lên: 07/03/2014, 00:20

... FEBS 1849 Biology and chemistry of b-secretase (BACE-1) C E Hunt and A J Turner BACE-1 promoter, and several studies have reported the upregulation of BACE-1 mRNA both in vitro and in vivo following ... Biology and chemistry of b-secretase (BACE-1) C E Hunt and A J Turner A B Fig Processing of APP to form Ab peptides (A) Schematic diagram of the alternative p...

Ngày tải lên: 07/03/2014, 00:20

... absence of ribosomal RNA synthesis, the ribosomal proteins of HeLa cells are synthesized normally and degraded rapidly J Mol Biol 115, 31 5–3 33 90 Komili S, Farny NG, Roth FP & Silver PA (2007) Functional ... sclerosis complex (TSC) 1– TSC2, and the mammalian target of rapamycin (mTOR) C1 complex (composed of raptor, mLst8, and mTOR) The role of TSC1–TSC2 in the t...

Ngày tải lên: 07/03/2014, 01:20