Functional analyses of the conserved cysteine rich with EGF like domains (creld) protein family in mus musculus

... signaling proteins2 The function of these domains can vary within one protein family, like in the selectin protein- family3 They contain one EGF- like domain facing the extracellular matrix, which ... highly conserved in all members of the Creld protein family1 The function of the WE domain has not been identified so far, but it has been proposed to play...

Ngày tải lên: 19/11/2015, 16:33

... Primary angiitis of the central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous ... Neuropsychopharmacol Biol Psychiatry 2005, 29:627-631 Carandang C, Grant A: Delirium and Isolated Angiitis of the Central Nervous System: a Case...

Ngày tải lên: 09/08/2014, 02:20

... showing it to be the aldosterone synthase of the guinea pig It was interesting to note that CYP11B2 of the guinea pig had a considerably higher enzymatic activity in terms of 11b-hydroxylated ... 11bhydroxylase activity of CYP11B1 was strongly reduced (Fig 5), whereas that of the aldosterone synthase was basically unaffected, while the 18-hydroxla...

Ngày tải lên: 22/02/2014, 07:20

... and phycocyanins, HPLC separation allowed a quantitative estimation of the relative amount of each protein component from the area underlying each peak This was facilitated by the fact that the ... region rich in amino acids with a higher than average contribution to the UV optical absorption and protonation of amino groups by electrospray ionization, leading to fals...

Ngày tải lên: 08/03/2014, 16:20

... around the glycosidic bonds in the bound substrates u is the O5–C1–O4¢–C4¢ angle and w is the C1–O4 – C4¢–C5¢ angle, where O4 represents the oxygen of the glycosidic bond and atoms of the adjacent ... Stereo figures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars and the side-ch...

Ngày tải lên: 15/03/2014, 11:20

... FNIII domains of gp130 are therefore assumed to be arranged in such a way that the C-terminal parts of the membrane-proximal domain D6 are positioned in close vicinity to each other In analogy, ... correct spacing and orientation of the cytoplasmic parts of the receptors for signalling An exchange of gp130 D6 with a domain that does not allow interactions...

Ngày tải lên: 18/03/2014, 01:20

... structure allows us to compare the R45 0A variant with WT FhaC Overall, the structure of the FhaCR45 0A variant is very similar to the A B Fig Overlay assay showing FHA–FhaC interactions The FHA derivative ... built as a polyalanine chain In the FhaCR45 0A structure, the residues 441–463 of L6 were not visible in the electron density map and are not included in...

Ngày tải lên: 23/03/2014, 03:20

... N- and C-terminal parts of the ligand are cross-linked to domains I and III, respectively, of the receptor [19,22] The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ... cognate ligand, EGF, we verified the assays using the chimeras, because the contributions of the ErbB-1 ectodomains to the EGF binding had already been...

Ngày tải lên: 24/03/2014, 03:21

... the device, the microorganism uptake the CO2 dissolved in the water because of the existence of the CO2 concentration difference between the inside (low) and outside (high) of the cell When the ... represent the data range.) CONCLUSION (1) The optimum operational condition of the device is a pressure of 0.3 MPa When a high- dissolved CO2 device is...

Ngày tải lên: 05/09/2013, 10:15

... impaired phosphorylation of Tyr394 did not appear to influence the binding of tau to Fyn- SH2, as there was no significant difference in the amount of Y394F 2930 Fig Tau interactions with Fyn- SH3 are not ... phosphorylation mediates the association of tau with Fyn- SH2, but not with Fyn- SH3 This demonstrates that different molecular mechanisms...

Ngày tải lên: 14/02/2014, 14:20

... S103 G145/D137 Y 112 D2 01/ 193 L75/67 G145/D137 E1 41/ 133 K173 /16 5 R207 /19 9 G77/69 D142 /13 4 G197 /18 9 Fig Superposition of PRTFDC1 with HPRT-ImmGP (Protein Data Bank code: 1BZY) (A) Residues in the ... Welin et al Studies of the human PRTFDC1 B A PRTFDC1 25 HPRT 20 10 00 0.2 800 600 400 0 .1 200 –50 50 10 10 50 10 015 0 200 250 S 200 –50 250 50 12 00 10 0 15 0 [H...

Ngày tải lên: 15/02/2014, 01:20

... mechanism of both RNA and DNA synthesis [17] In a previous study, we reported the findings of an analysis of the complete sequence of the cryptic plasmid pIT3 isolated from the crenarchaeon S solfataricus ... analyses of the predicted amino acid sequence showed that the C-terminal half of the RepA of the pIT3 plasmid is sequence-similar to the heli...

Ngày tải lên: 18/02/2014, 18:20

... activity of DEC1 is also required for the interaction with BMAL1 Binding of DEC1 mutants to a CACGTG E-box To examine the binding ability of DEC1 mutants to the CACGTG E-box in the Dec1 promoter, ... for DEC1 suppressive activity against CLOCK/BMAL1-induced transcription In addition, the N-terminal region of DEC1, including the bHLH domain, interacted with...

Ngày tải lên: 19/02/2014, 16:20

... and the unpairing of four base-pairs in the centre of the junctions [19] Detailed understanding of the functional role of these interactions would require the crystal structure of the Ydc2 junction ... positioning of the SAP motifs in relation to the rest of the protein as well as for the stability of the protein The truncated Ydc2 mutant prote...

Ngày tải lên: 20/02/2014, 11:20

... On the basis of the results with antibodies, a series of PrP mutants were made to assess whether deletions of certain domains of the protein decrease the SOD-like activity of the protein The domains ... the SOD activity We determined that the active site consists of two domains The first includes the Cu-binding domain and the second includes the conser...

Ngày tải lên: 21/02/2014, 00:20