Mapping targets of immune responses in complete dengue viral genomes

... Control of large changes in metabolic branches F Ortega and L Acerenza divides the system into modules, grouping together all that is irrelevant to the question of interest, including all ... general theory of modular MCA for large responses is developed to include the analysis of branched systems This formalism enables the analysis of systems with three...

Ngày tải lên: 14/03/2014, 23:20

... cisplatin and BCNU, concentrations of cytarabine routinely achieved in the clinic were highly toxic for neural progenitor cells in vitro Cerebrospinal fluid concentrations of cytarabine during conventional ... Immunofluorescence and TUNEL staining in vivo Free-floating sections (40 µm) were used for all in vivo experiments for TUNEL staining and combined immunofluoresc...

Ngày tải lên: 06/08/2014, 18:21

... Mason D: Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin in the prevention of autoimmune thyroiditis in rats by peripheral ... then made to phenotype putative TR cells more specifically by isolating the T lymphocyte fraction that harboured regulatory activity Sakaguchi and colleagues manag...

Ngày tải lên: 09/08/2014, 01:23

... suggesting that the elevation of IL-4 production during an ongoing immune response to tumor can down-regulate Th1 cytokine production Therefore, in gastrointestinal cancer patients, the initial ... adding an equal volume of 4% formaldehyde fixative After washing and incubating with PBS/BSA/saponin for 10 min, cells were incubated with for 30 min, respectively Results were analyzed usin...

Ngày tải lên: 09/08/2014, 04:21

... phagocyte production of transforming growth factor-β and IL-10 In addition, Gas-6 on apoptotic cells binding to receptor kinases of Tyro family (mer, tyro and axl) downregulate inflammatory cytokines, ... pivotal roles in SLE TLR7 and TLR8 bind to single-stranded RNA, TLR3 to double-stranded RNA, and TLR to DNA These receptors are intracellular and are engaged by their ligands...

Ngày tải lên: 09/08/2014, 10:21

... as: Eng et al.: PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens Journal of Immune Based Therapies and Vaccines 2010 8:4 ... Protection against influenza virus infection by vaccine inoculated intranasally with cholera toxin B subunit Vaccine 1988, 6:409-413 27 Tamura S, Ito Y, Asanum...

Ngày tải lên: 11/08/2014, 08:21

... specific CD4+ cells in response to vaccination is important in that these cells play a key role in activation of both B cells and CD8+ cells, and in controlling CTL responses [20], and are linked ... used in mice in a DNA vaccine prime/VLP boost vaccination regimen [12] Novel results presented here include the induction of predominantly specific CD4+ cells producing IFN-g and...

Ngày tải lên: 11/08/2014, 08:21

... this article as: Whitney et al.: Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of ... demonstrated that oral inoculation of live attenuated Lmdd and i.v D-ala administration was safe and well tolerated in rhesus macaques Liver to...

Ngày tải lên: 11/08/2014, 08:21

... Immunoassay (cLIA) Sera from rhesus macaques immunized with µg each of HPV 6, 11, 16 and 18L1-VLPs formulated with Merck Aluminum Adjuvant (MAA) (-◆-) or µg each of HPV 6, 11, 16 and 18L1-VLPs ... targeting HPV 6, 11, 16 and 18 will target the majority of HPV- related clinical disease Recently, we reported a proof -of- concept efficacy st...

Ngày tải lên: 11/08/2014, 10:23

... irrelevant gene (encoding the N protein of the Puumala virus, PUU-N) and six animals with pcDNA 3.1 vectors without insert After four rounds of immunisations, half of the mice of each vaccination group ... recombinant proteins The sera were obtained from (B) seven mice vaccinated with cDNA encoding the complete N protein or (C) nine mice infected with RVFV The sera...

Ngày tải lên: 12/08/2014, 04:21

... of CD4+ and CD4+CCR5+ T-cells in blood, BAL, duodenum and colon of SIV- infected controllers and progressors in comparison to uninfected animals The fraction of CD4+ T-lymphocytes in blood and ... Schultheiss et al.: Strong mucosal immune responses in SIV infected macaques contribute to viral control and preserved CD4 + T-cell levels in...

Ngày tải lên: 13/08/2014, 01:20

... engineered particles did not induce antibody responses to any of the tested antigens Functional assays illustrating surface-engineered Influenza-based particle induction of cross-strain antibody formation ... HSV-2 particles (Fig 4B) The third immune assay monitored the ability of surfaceengineered non -infectious viral particles to induce specific viral antibody responses...

Ngày tải lên: 13/08/2014, 09:21

... the clinical course of hepatitis C infection HCV- specific CD4+ T cells are involved in eradication of the virus in acute infection but their responses are weak and insufficient in chronic hepatitis ... Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV transgenic mice Comparative Hep...

Ngày tải lên: 13/08/2014, 13:20

... macrophages therefore play an important role in protecting the host against invading pathogens as the pro-inflammatory cytokines produced would result in the killing and elimination of the invading pathogens ... effective interplay of the both arms in the immune system 1.2 Innate Immunity 1.2.1 Overview of Innate Immunity The innate immunity is known as the fro...

Ngày tải lên: 16/10/2015, 11:59

... diversity Mapping targets of immune responses in viral antigens is an important pre-requisite to antigenic diversity analysis 18 2.3 Mapping targets of immune responses in dengue viral genomes ... peptide targets for vaccine formulation Immunogenic is defined as capable of producing an immune response 14 2.1.3 Targets of immune responses in den...

Ngày tải lên: 10/11/2015, 12:27