idiotype+specific+stimulation+of+immune+responses

... the inhibition of APCs or pathogenic T cells, by maintenance of the TR cell population and/or by enhancement of their function (reviewed in [54]) Elucidation of the mechanism of TR cell suppression ... in mice by elimination of T cell subset I Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease J Exp ... in the control of immune responses Transplantation 2003, 75:8S-12S 50 Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F: An essential role for interleukin 10 in the function of regulatory T...

Ngày tải lên: 09/08/2014, 01:23

... pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV Journal of Immune Based Therapies and Vaccines 2011 9:2 Page of Submit your next manuscript ... ELISpot responses were detectable in most animals During the course of the three vaccinations, all animals mounted positive IFN-g ELISpot responses to Gag peptide stimulation, although kinetics of ... induce Gagspecific cellular immune responses, even in the presence of multiple prior Lmdd exposures Anti-vector and anti-HIV Gag antibody responses To test for the presence of anti-Lm antibodies,...

Ngày tải lên: 11/08/2014, 08:21

... approved by The Animal Research Ethics Committee of Umeå University, Sweden Evaluation of immune response To evaluate and compare the immune responses after vaccination and infection, eight animals ... carbencillin to OD A600 of 0.7 Expression of the antigens was induced by the addition of isopropyl-beta-D-thiogalactopyranoside (IPTG) at a final concentration of 0.5 Page of 10 (page number not ... contaminating amounts of endotoxins [30] Each batch was tested for unspecific stimulation of splenocytes before use Enzyme-linked immunosorbent assay (ELISA), Western blot and Immunofluorescence analysis...

Ngày tải lên: 12/08/2014, 04:21

... cell CD28 receptor, and fragment C of tetanus toxoid Implantation of these cells in mice resulted in successful in vivo induction of tetanus toxoid specific immune responses [25] Although successful, ... supports the premise that the observed inhibition of HIV replication is not due to massive apoptosis of CD4-positive cells Induction of specific antibody responses Unlike HIV-1, HSV-2 does not replicate ... performed by the addition of 1.2 g of PEG (MW = 3,350) and 2.2 g of NaCl per 100 ml of culture supernatants, resulting in a 6% final concentration that would favor the recovery of particles relative...

Ngày tải lên: 13/08/2014, 09:21

... tracking a larger number of immune components are often desirable when studying the progression of an infection or disease Given our need to study the dynamics of immune responses to infection ... can parameterize the continuous change of immune components as a function of time The model reveals specific parameters defining the dynamics of the host’s immune processes that are important in ... components of the immune response, which can include interactions between pathogen and host factors and the subsequent generation of specific antibody and T cell responses The choice of mathematical...

Ngày tải lên: 13/08/2014, 16:20

... Master studies I TABLE OF CONTENTS Acknowledgements I Table of Contents II Summary VII List of Tables VIII List of Figures IX List of Abbreviations XI Chapter Introduction 1.1 The Immune System 1.2 ... self and non-self In doing so, the immune system will then be able to induce appropriate and yet specific immune responses towards the specific pathogens The immune system in mammals can be classified ... other important function of innate immunity is to process and present captured antigens for the stimulation of adaptive immune responses The innate immunity relies on a set of germ-line encoded receptors...

Ngày tải lên: 16/10/2015, 11:59

... 13 2.1.2 Immune responses to dengue virus infection 13 2.1.3 Targets of immune responses in dengue viral genome 15 2.2 Antigenic diversity of targets of immune responses in ... B-cell epitopes on the surface of dengue virus Cellular immune responses, such as cytotoxic and helper T-lymphocyte responses, are an essential part of the specific immune responses to DENV infections ... capable of producing an immune response 14 2.1.3 Targets of immune responses in dengue viral genome The principal targets of cellular immune response to DENV are shown in Table 2.1 The T cell responses...

Ngày tải lên: 10/11/2015, 12:27

... Further, only small amounts of phytol and PHIS-01 are required to stimulate immune responses None of these two compounds stimulates reaginic immune responses, nor induces autoimmune lupus-like syndromes ... 10 120 100 80 60 40 20 E/T ratio Figure Induction of tumor specific- cytotoxic effector responses Induction of tumor specific- cytotoxic effector responses Spleen cells were obtained from C57BL/6 ... Acknowledgements The authors thank Professors William Brett and Jim Hughes of the Department of Life sciences and Tista Page of 11 (page number not for citation purposes) Journal of Immune Based Therapies...

Ngày tải lên: 11/08/2014, 10:23

Ngày tải lên: 11/08/2014, 10:23

... that predispose to the development of allergic immune responses are the focus of recent studies [1] Prior investigations have examined the development of allergen -specific T cell memory cells that ... detection of the PCR product was monitored by measuring the increase in fluorescence caused by the binding of SYBR Green to dsDNA Using µl of cDNA, µl of primer, and 10 µl of SYBR Page of (page ... supernatants of CBMC were determined following stimulation with the indicated doses of Ppg and Derf1 Lymphocyte proliferation shown as SI (stimulation index, ratio of mean counts per minute of stimulated...

Ngày tải lên: 12/08/2014, 16:20

... Control of Innate and Adaptive Immune Responses during Infectious Diseases Julio Aliberti Editor Control of Innate and Adaptive Immune Responses during Infectious Diseases ... severe in patients carrying higher loads of bacilli 2 Mechanisms of Host Protection and Pathogen Evasion of Immune Response… 2.4 2.4.1 31 Evasion of Immune Response Cell Wall Components Mycobacteria ... lines of evidence indicate that without innate immune responses, such as following NK-cell depletion, the initial IFN- -dependent control of parasite replication is compromised and, in the case of...

Ngày tải lên: 05/03/2014, 23:20

... Page of 11 The a priori level of significance was a p-value of < 0.05 Data was computed using JMP® software Results Safety Two out of the 33 enrolled patients were removed from the 1.25 mg arm of ... functionality of monocytes after treatment, we considered the upregulation of the expression of any one of these independent markers by more than 50% to be a gain of function In the 1.25 mg-group, 28% of ... we saw a doubling of the objective response rate which suggests that IMP321 is a potent agonist of effective anti-cancer cellular immune responses in this clinical setting Page of 11 Table Patients...

Ngày tải lên: 18/06/2014, 16:20

... Mark et al Journal of Occupational Medicine and Toxicology 2010, 5:18 http://www.occup-med.com/content/5/1/18 deprivation and thereby an induction of proinflammatory immune responses [7-9] Cytokine ... shift schedules The mean age of shift workers was 36.4 yrs (SD 9.34) and the mean age of daytime workers 40.1 yrs (SD 7.77; p < 0.001) 86.9% of the shift workers and 75.7% of the day workers were ... influence of chronic sleep debt and circadian disruption on the immune system we compared cytokine production and lymphocytes count in a morning blood sample of shift workers with Table Influence of...

Ngày tải lên: 20/06/2014, 00:20

... innate and cellular responses (NK, NKT, and CD8+ T cell responses) associated with clearance of influenza viral infected cells [23] The role of innate and adaptive cellular responses to influenza ... epitopes of influenza proteins in the context of a highly immunogenic, non-infectious structure VLPs elicit immune responses and protection at low doses (HA content) and without the use of an exogenous ... efficient immune responses Curr HIV Res 2006, 4:475-484 McBurney SP, Young KR, Ross TM: Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses...

Ngày tải lên: 20/06/2014, 01:20

... particles can induce the production of antigen -specific Ab responses including antigen -specific Th2 allergic immune responses Antigen -specific cytokine responses of silica particles To clarify the ... capable of inducing allergic immune responses and have the potential to cause serious allergic symptoms Antigen -specific IgG Abs subclass responses of silica particles Next, to assess the types of immune ... shown) To investigate the potential of silica particles to enhance allergic immune responses, we examined their effect on the production of allergenspecific Abs responses in vivo On days 0, 1, and...

Ngày tải lên: 21/06/2014, 05:20

... humoral immune responses of T-1 and T-2 were greater than those of T-3 or control group A report supports the result of our study, suggesting that in pigs the Ig-containing cells isotypes of the ... humoral immune responses of T-1 and T-2 were greater than those of T-3 or control group According to the maternal antibody derived from sows, it may have potentials to interfere with specific ... proportion of N cells, but that of N lymphocytes was distinct for that of T-2, compared to that of control at 8-weeks PA The enhancement of host defense system using nonspecific immunomodulators could...

Ngày tải lên: 07/08/2014, 14:23

... challenge (data not shown) Immune responses with S cerevisiae expressing rApxIA or rApxIIA 387 Induction of specific immune responses The levels of local and systemic antibodies specific to the Apx ... involvement of IL-6 in Immune responses with S cerevisiae expressing rApxIA or rApxIIA 391 the production of IgA and the induction of TNF-α by IgA [23] Moreover, the dual capacities of secreted ... administration of the ApxIIA We first confirmed the immunogenicity of the yeast-derived ApxIA antigen We then investigated the local and systemic immune responses, bacterial clearance, and inflammatory responses...

Ngày tải lên: 07/08/2014, 20:23

... number of apoptotic OVA -specific CD8+ T cells was determined by flow cytometry (FACScan, BD Biosciences) and expressed as a percentage of the total number of OVA -specific CD8+ cells Analysis of the ... humans because of the use of lipofectamine, which is toxic to humans Oromucosal therapy with recombinant IFN reduced the severity of viral infection,44 but intranasal administration of IFN-c pDNA ... treatment caused a decrease in the number of IFN-cproducing, OVA -specific CD8+ T cells in the lungs of OVA-challenged mice To further assess the fate of OVA -specific CD8+ T cells, OVA-allergic C57...

Ngày tải lên: 08/08/2014, 21:20

... culminate in the activation of transcription of defensive genes Individual TLRs produce overlapping but distinct patterns of gene expression, permitting tailoring of host responses to different pathogens ... A number of in vitro studies have suggested that, similar to the involvement of CD14 in LPS signaling, CD14 plays an essential role in the activation of PG-PS induced innate immune responses ... stimulation induces degradation of IκB, thereby allowing NF-κB to enter the nucleus and initiate the transcription of target genes [27] Thus, the nuclear localization of NF-κB is indicative of...

Ngày tải lên: 09/08/2014, 01:23

... regulation of LPS responses Immunity 2002, 17:677-687 Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ: Re-examination of the role of suppressor of cytokine signaling (SOCS1) in the regulation of ... weeks of age about 50% of the SOCS7-deficient mice died as a result of hydrocephalus that was characterized by cranial distortion, dilation of the ventricular system, reduced thickness of the ... the action of SOCS2 is in the regulation of the GH signaling pathway SOCS3 SOCS3 KO mice die by placental function defects during the embryonic stage of development [41,42] Deletion of SOCS3 causes...

Ngày tải lên: 09/08/2014, 06:23