modulation of immune cells in allergic inflammation
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ⁄ reperfusion injury [14] In our studies, ... receptor signaling is independent of Toll-interleukin receptor domain-containing adaptor protein Drug Metab Dispos 36, 95–101 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic ... MA, USA) Binding of all of the antibodies was detected using an ECL detection system (iNtRON Biotechnology, Seoul, Korea) in accordance with the manufacturer’s instructions The intensity of the...
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Báo cáo hóa học: " Modulation of viral replication in macrophages persistently infected with the DA strain of Theiler''''s murine encephalomyelitis virus" docx
... accumulation of leukocytes in specific tissue sites Accumulating evidence indicates a role for chemokines in the pathogenesis of various CNS inflammatory diseases, including MS and virus-induced demyelination ... Figure hemin on DRAW and RAW cells Effect of1 Effect of hemin on DRAW and RAW cells Cells, seeded at a density of 2.5 × 104 cells/ well in 96-well plates, were treated with 65 μg/ml hemin or untreated ... between hemin-treated RAW and DRAW cells Phasecontrast images of (C) hemin-induced lysis of DRAW cells and (D) normal appearing hemin-treated RAW cells Magnification: 400× 2B) To ascertain that...
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Báo cáo hóa học: " Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11" ppt
... well as NK cells, the relative contribution of each cell type could not be determined CD8+ T cells and NK cells inhibit virus replication in vitro through a variety of mechanisms, including cytolytic ... ADCVI-mediating antibodies can be found early during HIV-1 infection and reduce HIV-1 yield both by lysis of infected target cells and by the release of betachemokines from NK effector cells [27,28] In ... grown in CEMx174 cells) Immediately before virus inoculation, animals were depleted of CD8+ cells via administration of the anti-CD8 antibody cM-T807 at a dose of 50 mg/kg body weight (administered...
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Báo cáo khoa học: "Comparative study of endocrine cells in the principal pancreatic islets of two teleosts, Silurus asotus (Siluridae) and Siniperca scherzeri (Centropomidae)" potx
... frequency of endocrine cells, immunoreactivity to antisera against mammalian insulin, glucagon, somatostatin and PP, in the pancreas of teleosts, localization of endocrine cells in the principal ... frequency of endocrine cells in the principal islets of two species of teleostean fishes are summarized in Table Table Antisera used in this study Antisera* Insulin Glucagon Somatostatin Bovine pancreatic ... secretion of the gastrin, cholecystokinin, secretin, glucagon, insulin, motilin and gastric acid (Kitamura et al., 1984) and the absorption of amino acid, glucose and fatty acid in the gastrointestinal...
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Báo cáo khoa học: " Hematology, cytochemistry and ultrastructure of blood cells in fishing cat (Felis viverrina)" ppt
... yltniaf dna elbinrecsidni tsomla htiw suelcun detcirtsnoc dah yehT )1 elbaT( setycokuel tnelaverp tsom eht erew slihportueN slihportueN sgniniats lacimehcotyc lla rof evitagen erew yehT dnuof netfo ... tiknurihirP kasgnaerK 461 .ylevitcepser ,SAP dna ulg-β rof evitisop ylkaew )G & F( EANA rof evitisop ylgnorts )E( ylevitcepser ,BBS dna REP rof evitagen )D & C( ylevitcepser ,W dna GW ,selunarg ... ,selunarg epahs-dor htiw lihponisoe na )B & A( :slihponisoE SAP rof evitisop ylgnorts )G( ulg-β rof deniats ylevitisop )F( EANA rof evitisop ylkaew )E( ylevitcepser ,BBS dna REP ,slihportuen evitisop...
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Báo cáo khoa học: "Differentiation of xylem cells in rolC transgenic aspen trees – a study of secondary cell wall development" ppt
... Giemsa staining, light micrograph Bar = 100 µm (d) Formation of secondary walls and gelatinous layers (pale stained inner wall layers) close to the cambium, even in dividing cells, PATAg staining, ... with intense staining, 15–16 cell rows from the cambium 682 C Grünwald et al of their S1 and also of the S2 layer already undergoing formation in this region (figures 2d,e) With increasing distance ... of xylem cells in rolC aspen 683 Figure Changes in the UV-absorption at 272 nm measured in middle lamella regions (M) and secondary walls of developing fibres (S) (a) Wild type tree, linear increase...
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Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx
... pre-activated T cells in pathogen-induced chronic inflammatory joint diseases Any diseases inflammation will cause the induction of chemokine and cytokine production in several tissue-associated cells in ... synovial lining cells, B cells and T cells in the pathogenesis of CIJD (for a recent review on this, see [2]) R442 The cytokine profile in the serum of patients with inflammatory joint disease ... protein 60 [62] Relevance of the findings The question of whether our findings are of any significance for the understanding of CIJD is justified and needs answering TLR ligands are found in the...
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Báo cáo y học: " Interrelated modulation of endothelial function in Behcet''''s disease by clinical activity and corticosteroid treatmen" ppt
... effects of corticosteroid treatment on endothelial function in patients with chronic inflammatory diseases Interestingly, administration of corticosteroids improves endothelial function in patients ... studied, noninvasively, by means of brachial artery FMD, as described previously [15] Patients and control individuals abstained from consumption of tobacco, coffee, alcohol, antioxidant-containing beverages ... main finding of the cross-sectional observational study was that endothelial function in patients with BD is modulated by both clinical disease activity and use of corticosteroids, albeit in...
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Báo cáo y học: "Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients" doc
... extended the findings of our previous study to investigate, within induced sputum, the number and cytotoxic function of the three main classes of human killer cells; CD8 + T lymphocytes, NK cells and ... was no difference in the proportions of CD56dim CD16+ NK cells and CD56 brightCD16- NK cells expressing only perforin and no granzyme B Examining the proportion of cells expressing only granzyme ... significant difference in smoking history between COPD subjects and healthy smokers Comparison of constituent cells in induced sputum The viability of the cells (% total) in induced sputum did not...
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Báo cáo y học: " Involvement of mast cells in monocrotalineinduced pulmonary hypertension in rats" pot
... remodeling However, a systematic examination of pulmonary MCs in clinical and experimental PH and an elucidation of the role of MCs in animal model of progressive PH are still missing In this ... population of interest, was prevalent in MCT-rats (p < 0.05 versus healthy rats) Interestingly, there was about 9-fold increase in the number of MCs around the intra-acinar vessels (20-50 μm in diameter), ... after MCT-injection The rats in healthy group received saline injection instead of MCT Double immunostaining for von Willebrand factor and a-smooth muscle actin, and elastica staining were performed...
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Báo cáo y học: " CD39+ Regulatory T cells suppress generation and differentiation of Th17 cells in human malignant pleural effusion via a LAP-dependent mechanism" pps
... findings [14], we noted that percentages of Th17 cells represented the higher values in MPE (3.7 ± 0.4%), showing a significant increase in comparison with those in the Page of 10 corresponding ... stimulated by cytokines and to recruitment from peripheral blood induced by chemokines, the numbers of Th17 cells were significantly increased in MPE, and that the accumulation of Th17 cells in MPE predicted ... naïve CD4+ T cells after culturing in presence both IL-1b and IL-6 (C) The representative dot plots of CD39+Tregs and Th17 cells detected in naïve CD4+ T cells after culturing in presence of TGF-b1...
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Báo cáo y học: " Does unrestrained single-chamber plethysmography provide a valid assessment of airway responsiveness in allergic BALB/c mice?" doc
... those in the OVA-1D group (see Table 2, Figure 4B– F) Inflammation in OVA-1D mice consisted of minimalto-mild inflammation in peribronchiolar and perivascular interstitial infiltrates of eosinophils, ... present mainly in the subepithelial layer along the edge of the upper turbinate and consisted primarily of infiltrating eosinophils and mononuclear cells (see Figure 7) The median number of eosinophils ... corresponding baseline values The provocative concentrations of the agonist that increased Penh to 200% and 300% of baseline (PCPenh200, PCPenh300) were obtained by linear interpolation of the concentration...
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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
... likely since the inflammatory response to epithelial damage was also attenuated in the γδ T cell deficient mice Our findings are consistent with a role of γδ T cells in determining the magnitude of ... the inflammatory response to acute epithelial injury and in maintaining and repairing the epithelial barrier [16] Chen et al have found that a deficiency of γδ T cells rendered the intestinal ... and BAL protein content were measured Cl2 inhalation caused extensive shedding of the airway epithelial cells (figure 2A) A significant increase in the number of epithelial cells in BAL was observed...
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Báo cáo y học: " Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus" potx
... expression of a4b7 integrin is regulated in a homeostatic relation with the surface expression of a4b1 integrin on T -cells since high expression of a4b1 integrin resulted in a loss of a4b7 integrin With ... tyrosine kinase) which is involved in BCR signaling, but also in the regulation of integrin activation [44] Moreover, recent work indicates that Syk is involved in CXCL12- and a4b1 integrin-induced ... data indicate that b1 integrin and b7 integrin expression could be regulated interdependently on CD27 negative B -cells In addition, binding to CD22 by epratuzumab provoked the activation of b1 integrin...
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Báo cáo y học: "Role of γδ T cells in protecting normal airway function" docx
... with the chronic intestinal inflammation In the course of the disease, increases in levels of γδ T cells were correlated with an increased expression of stress markers in the intestinal epithelia ... populations accumulating during inflammation in liver [23], testis [24] and other tissues, and in the brain of mice suffering from experimental autoimmune encephalitis [25] Intriguingly, the invariant TCR ... cells in allergic airway inflammation Science 1998, 280:1265–1267 The extent of airway inflammation after intranasal challenge of ovalbuminimmune mice was found to depend on the presence of γδ T cells...
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Báo cáo y học: " Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease" doc
... [38] Mast cells and eosinophils also synthesize interleukin-5, indicating that autocrine production of interleukin-5 may contribute to the chronicity of inflammation [41,42] The interleukin-5 receptor ... autophosphorylation Like interleukin-3 and GM-CSF, interleukin-5 induces rapid tyrosine phosphorylation of several proteins, further indicating that tyrosine kinases are involved in the cellular activation ... the interleukin-5-induced hyperreactivity was abated by blocking the activity of interleukin-1, and interleukin-1β mRNA and protein levels are increased by interleukin-5 Interleukin-5 may contribute...
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Báo cáo y học: " New approaches to the modulation of inflammatory processes in airway disease models" pdf
... anti-inflammatory activity in a range of in vitro and in vivo screens and is being followed up with a new lead compound, SPC reports In a session on the role of protein kinases in airway inflammatory ... involved in the production of various cytokines and although not present in T cells it has been shown to regulate the inflammatory response and the influx of T cells Also, animals deficient in lyn kinase ... goblet cells Secretion of serous mucus containing lysozyme is beneficial in dissolving mucus plugs AWD 12-281 increased the secretion of serous mucus in mouse trachea as well as reducing LPS-induced...
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Báo cáo y học: " Experimental depletion of CD8+ cells in acutely SIVagm-Infected African Green Monkeys results in increased viral replication" doc
... virus In these studies, the depletion of CD8+ T cells resulted in increased viral replication of either the challenge strain or the vaccine strain [27-33] Finally, the importance of CD8+ cells in ... the role of NK cells in HIV infections Even though our results show that depletion of CD8+ cells results in higher levels of viral replication during the Page of 13 acute SIVagm infection of AGMs, ... lowering VLs during antiretroviral therapy has also been reported in SIV-infected RMs [34,35] In spite of the overwhelming evidence of the active role that CD8+ cells may play during SIV infection...
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Báo cáo y học: "Characterization of Kupffer cells in livers of developing mice" ppt
... of developing mouse pups clearly poses a challenge to making reliable tail vein injections Although some investigators have provided instructions on intravenous injection (into scalp veins) in ... microsphere labelling following intravenous vs intraperitoneal injections, although the intravenous approach generally led to more intense labelling This finding indicates that greater numbers of fluorescently ... comparison of results of IV and IP injections Fluorescence images under rhodamine optics show labelling of mouse liver hr following intravenous (A) or intraperitoneal (D) injections of red labelled...
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Báo cáo y học: "Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy" ppsx
... occurred at the level of the inverted repeats (as, for example, during a block in DNA replication) Indeed, we obtained a product of the expected size with these pairs of primers in L infantum MTX20.5 ... doubling concentrations of MTX when cells were adapted to yield L infantum MTX20.5 growing at 20 μM of MTX All cells were grown in M199 medium supplemented with 10% heat-inactivated fetal bovine ... operating grants to MOu JMU is a Strategic Training Fellow of the Strategic Training Program in Microbial Resistance, a partnership of the CIHR Institute of Infection and Immunity and the Fonds de...
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- function of glial cells in brain
- role of glial cells in parkinson disease
- role of glial cells in cerebral ischemia
- role of glial cells in the formation and maintenance of synapses
- role of glial cells in pain
- role of glial cells in the nervous system
- pathogenic role of glial cells in parkinsons disease
- discuss the importance of glial cells in glutamatergic signalling
- importance of glial cells in glutamatergic signalling
- function of glial cells in the brain
- functions of glial cells in pns
- role of oxidative stress in pancreatic inflammation
- role of glial cells in the brain
- the role of nkt cells in the immune regulation of neoplastic disease
- bioactive polysaccharides of american ginseng panax quinquefolius l in modulation of immune fun
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