Regulation of chondrocyte differentiation potential involve

Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx

... preponderant role of p38 in the regulation of gene expression at the level of mRNA stability The p38 MAP kinase is now known to stabilize a wide range of mRNAs including those encoding TNF-a, interferon ... organization of the actin cytoskeleton and the superinduction of the CTGF/ CCN2 gene Rho-like GTPases play a pivotal role in orchestrating changes...

Ngày tải lên : 19/02/2014, 16:20

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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx

... IRF -3 responsive, including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-speciﬁc counterpart [16] The two isoforms ... ArgII expression was inhibited by MG- 132 [20], suggesting indirectly an involvement of NF-jB in ArgII regulation Our study is thus the ﬁrst direct demonstration...

Ngày tải lên : 07/03/2014, 21:20

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Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx

... that the PX domain of p47phox binds intramolecularly to the SH3 domain in the same protein, and that this intramolecular interaction suppresses the lipid-binding activity of the PX domain in the ... 5579 fad49 plays a crucial role in adipogenesis T Hishida et al Fig Characterization of the PX domain of FAD49 (A) Phosphoinositide binding speciﬁcity of the...

Ngày tải lên : 16/03/2014, 04:20

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Báo cáo khoa học: Involvement of NF-jB subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene pot

... retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the hGnRH II gene, the expression vector of human ... on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-...

Ngày tải lên : 16/03/2014, 10:20

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Báo cáo Y học: Identiﬁcation of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx

... might be similar to that by which they inhibit the enzymatic activity of TGase Hydrolysing activity of GTP was also found in the puriﬁed PpTGase protein as in the case of TGase Mammalian TGase ... Next, GTP- hydrolysing activity of the puriﬁed PpTGase was investigated Mammalian TGase has both transamidating and GTP- hydrolysing activities, whereas TGase has n...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo khoa học: Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells pptx

... These sites bind Sp1 and Sp3, and protein levels and binding of Sp1 and Sp3 are increased in PMAtreated cells These ﬁndings indicate that Sp1 and Sp3 play a pivotal role in the transcriptional ... and Sp3 are able to bind to the GC boxes and that binding of Sp1 forms complex C1 and binding of Sp3 forms complexes C2 and C3 PMA treatment increa...

Ngày tải lên : 23/03/2014, 17:21

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Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover pptx

... overproducing Sec14p and the ﬁve homologues were analyzed in the sec14ts background To assess the role of Sec14 homologues in the regulation of Pld1p-mediated PtdCho turnover a mutant lacking choline kinase ... form a network of proteins involved in the regulation of phospholipid metabolism Materials and methods Strains and culture conditions Yeast strains...

Ngày tải lên : 23/03/2014, 18:20

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Báo cáo sinh học: "Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets" doc

... upregulated during CD8+ T lymphocyte differentiation To investigate if defined microRNA profiles can be associated with CD8+ T cell differentiation status, the relative expression levels of the microRNAs ... preferentially during early memory differentiation Interestingly, not all members are regulated concomitantly, indicating a differential intra-cluster regulation in...

Ngày tải lên : 18/06/2014, 19:20

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Báo cáo sinh học: "Nuclear localization is required for Dishevelled function in Wnt/ -catenin signaling" pps

... Dsh-binding protein, is required for Wnt/ -catenin signaling in the nucleus [14] These interactions may take place in various cellular compartments, linking specific activities of Dsh to its distribution ... DEP domains [13] Different domains of Dsh are engaged in specific interactions with different proteins, thereby leading to distinct signaling outcomes [13] Daam, a formin...

Ngày tải lên : 06/08/2014, 18:21

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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx

... oxidative stress in OA cartilage, as discussed above, we postulated that oxidative stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ageing and ... pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere erosion, and chondrocyte senescence Our f...

Ngày tải lên : 09/08/2014, 06:22

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Báo cáo y học: "Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation" pot

... differentiation potential of human OA chondrocytes using microarray technology in order to determine whether OA chondrocytes might possibly be used in second-generation ACT Microarray analysis of human OA and ... chondrogenic differentiation in ND chondrocytes Gene expression analysis of chondrogenic potential of OA chondrocytes The expression pattern of gene...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc

... as: Brodsky et al.: The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages ... kinetics I At h, AS101 probably enters the nucleus and may interfere with the DNA-binding ability of the NFB complex resulting in...

Ngày tải lên : 11/08/2014, 08:22

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Regulation of WNT beta catenin pathway in the disease progression of osteosarcoma

... points in the Wnt/ β -catenin pathway with the aim of developing novel Wnt- targeted therapies to prevent or reduce osteosarcoma disease progression 1.4 Strategies in inhibiting the Wnt/ β -catenin ... while the tyrosine kinases Fer, Fyn or Met are capable of inducing phosphorylation of tyrosine residue 142 of β -catenin to disrupt interaction with α -catenin...

Ngày tải lên : 11/09/2015, 10:18

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Regulation of chondrocyte differentiation potential involvement of wnt ß catenin signaling

... irreversible dedifferentiation 15 1.3 Wnt/ β -catenin pathway 17 1.3.1 Association of Wnt/ β -catenin pathway with chondrocyte dedifferentiation 17 iii 1.3.2 Curcumin as a Wnt/ ... increased chondrocyte numbers, and a preserved redifferentiation capacity of chondrocytes was observed (Mandl, van der Veen et al 2004) 1.3 Wnt/ β -catenin pathway 1.3.1 Association of Wnt/...

Ngày tải lên : 16/10/2015, 15:38

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