Hydrogen sulfide produces cardioprotective effects against ischemia reperfusion injury via regulation of intracelluar PH

... value in the group of myocytes subjected to ischemia/ reperfusion injury 30 3.2 NaHS induced cardioprotection via regulation of intracellular pH 3.2.1 Effect of NaHS on pHi in the rat ventricular ... the cell viability of cardiac myocytes subjected to ischemia (30 min) /reperfusion (10 min) C, group data show the protective effects of NaHS against the cardiac myocytes injury induced by ischemia ... signaling mechanisms of H2S Moreover, researchers have recently found that pre- and post-conditioning with H2S produced cardioprotective effects against ischemic injury via regulation of protein kinase...

Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt

... as: Chen et al.: Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction Journal of Translational ... adipose-derived mesenchymal stem cells (ADMSCs) After culturing for 14 days, majority of isolated adipose-derived stem cells expressing CD29 and CD90 characteristic of mesenchymal stem cells (n = 3) Note ... tissue mesenchymal stem cells after transplantation into mice with liver injury Stem Cells 2008, 26:2705-2712 Sun CK, Zhang XY, Zimmermann A, Davis G, Wheatley AM: Effect of ischemia-reperfusion injury...

Role of cyclic AMP signalling mechanisms in heart protection against ischemia reperfusion injury

... glycogen in myocardium This promotes binding of Hexokinase II to the mitochondrial membrane and inhibition of mitochondria permeability transition pore (MPTP) opening Cyclic AMP- induced activation of ... analogue 8Br-cAMP-AM which activates both PKA and Epac effectively protects heart against ishaemia /reperfusion injury PKA and Epac act synergicaly in the cardioprotective effect of cAMP Scheme of Signal ... 2007;581:1147-61 Study of the signalling mechanisms of cardioprotective effect of temperature preconditioning have revealed that this intervention is mediated by consecutive activation of PKA and PKC...

Báo cáo y học: "Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts" pps

... extract of Desmodium gangeticum root induces myocardial protection against ischemia reperfusion injury in isolated rat hearts, as indicated by the improved recovery of cardiac function, reduction in ... et al.: Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts Chinese Medicine 2010 5:3 Submit your next manuscript ... injury (Table 4) Conclusion The ethyl acetate extract of Desmodium gangeticum root protects the myocardium against ischemia- reperfusioninduced damage in rats The effects of the extract may be...

Hydrogen sulfide, a cardioprotective agent in ischemic heart

... the accumulation of metabolites and inorganic phosphate With a substantial decline in ATP, the Na+, K+-ATPase is inhibited, resulting in a further decline of K+ and an increase in Na+ Intracellular ... stress, and cell adherence They function in a three-tier module comprising of a MAPK kinase kinase, a MAPK kinase and a MAPK The mammalian MAPK can be subdivided into five families: 42 and 44-kDa extracellular ... cardiac myocytes Journal of Pharmacology Experimental Therapeutics, 2006; 316(2):670-8 ii ABBREVIATIONS AAR area at risk BCA β-cyano-L-alanine CABG coronary artery bypass grafting CBS cystathionine...

Báo cáo sinh học: "The combined transduction of copper, zincsuperoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury" ppt

... transduction of copper, zinc-superoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury Journal of Translational Medicine 2011 ... (1:20) for followed by PI for 15 The apoptosis rate was evaluated by Flow cytometry Transduction of PEP-1-SOD1 and/ or PEP-1-CAT in rat myocardium and ischemia-reperfusion injury To observe whether ... the apoptosis of cells were indicators of hypoxiareoxygenation injury [25,26] Our previous studies have shown that application of PEP-1-SOD1 or PEP-1-CAT can tranduced into myocardium and protected...

Báo cáo khoa học: " Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury" pps

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Báo cáo khoa học: "Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation" pps

... a rof nekat erew yendik tfel eht morf selpmas eussit ehT ld/gm 8.1< ot dezilamron dah seulav eninitaerc mures eht fi keew tnalpsnart-tsop driht eht retfa seninac gnivivrus eht gnizinahtue rof ... syendik ehT seimotcerhpen eht erofeb nim 02 )aeroK ,mrahP naH iaD ;VI ,gk/g 1( lotinnam deretsinimda erew sgod ehT )VI ,h/gk/lm 01( noitulos etylortcele decnalab a deretsinimda erew sgod eht llA erudecorp ... ,snouH ;CS ,gk/gm 40.0( etaflus eniporta htiw detacidemerp era slamina eht ,tsaf thginrevo na retfA la te noitatnalpsnarT noitatnalpsnartotua yb dewollof puorg tnemtaert eht ni desufrep erew )aeroK...

Báo cáo y học: "Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rat" pptx

... Discussion Nerve pathology in acute ischemic injury has beeen delineated in peripheral nerve and reperfusion injury could amplify ischemic pathology Nerve ischemia plays a major role in the development ... blunt injury to the abdominal aorta J Trauma -Injury Inferction and Critical Care 2003, 55:795-799 Murry CE, Jennings RB, Reimer KA: Preconditioning with ischemia: a delay of lethal cell injury in ... Hematoxylen esozine 40× magnification sue and their elevation has been reported to play an essential role in reducing the severity of the I/R injury by inhibiting neutrophil adhesion in postcapillary...

Báo cáo y học: "Ipsilateral common iliac artery plus femoral artery clamping for inducing sciatic nerve ischemia/reperfusion injury in rats: a reliable and simple method" doc

... competing interests Authors' contributions MN participating in drafting the manuscript RR participating in drafting the manuscript and statistical analysis GF participating in statistical analysis ... producing serious neurologic deficits and still technically feasible For this purpose, clamping of both the femoral artery and ipsilateral common iliac artery was performed to induce sciatic nerve ... time intervals In another model introduced by Saray and his colleagues [2], only femoral artery and vein – just distal to the inguinal ligament – are clamped for hrs followed by reperfusion The former...

Báo cáo y học: "Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits" docx

... particularly in combination with cisplatin administration [10] To the best of our knowledge, there have been no other studies investigating the direct or indirect protective effects of Amifostine in spinal ... achieve the highest concentration of its active metabolite during the time of free radical accumulation in spinal cord cells, by intra-aortic administration, just prior to the release of the aortic ... unreliable In addition, the re-agent we used for free radicals detection has an acting-time limitation of 75 minutes As the positive results of the effectiveness of Amifostine as scavenger of free radicals...

Báo cáo y học: " Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation" ppt

... Posttransplant strategies to reduce I/R injury include the administration of substances that interfere with the inflammatory process mainly with the action of chemokines, cytokines, or leukocyte infiltration ... play a crucial role in mediating I/R injury after transplantation An important group of pro-inflammatory cytokines is the interleukin-1 family Here particularly IL-1β is of interest as it can link ... [7] Page of However, not only locally generated inflammatory mediadtors like cytokines/chemokines [8] resulting from I/R injury but also systemic inflammatory mediators in the donor affect the graft...

Báo cáo y học: " tài: Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation" potx

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