a 2a adenosine receptors and ischemia reperfusion injury
Báo cáo y học: "Ipsilateral common iliac artery plus femoral artery clamping for inducing sciatic nerve ischemia/reperfusion injury in rats: a reliable and simple method" doc
... participating in drafting the manuscript and statistical analysis GF participating in statistical analysis and study design MRR: Preparing the revised paper and drafting the manuscript SMR participating ... tests were used to compare behavioral and pathologic scores (i.e edema and IFD grades) among the groups Data throughout the manuscript are presented as median All statistical analyses were performed ... Mitsui et al [1], the abdominal aorta, the right iliac and femoral arteries, and all identifiable collateral vessels supplying the right sciatic-tibial nerve are ligated for hrs and then reperfused...
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Báo cáo y học: "A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion" pps
... Results are expressed as mean ± standard error of the mean Data were analyzed using SigmaStat (Jandel; San Rafael, CA, USA) Ischemia/ reperfusion- induced lung injury and apoptosis Two hours of ischemia ... Values are expressed as means ± standard error of the mean (n = 5–6 cats/group) IB-MECA and MRS3558 are A3 adenosine receptor (AR) agonists, and MRS1191 is an A3 AR antagonist The groups were as ... P, Carter MF, Jacobson KA: Adenosine A3 receptor stimulation and cerebral ischemia Eur J Pharmacol 1994, 263:59-67 Fedorova IM, Jacobson MA, Basile A, Jacobson KA: Behavioral characterization...
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Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt
... inhalational isoflurane and placed in a supine position on a warming pad at 37°C Renal IR was then conducted in group and group animals on which a midline laparotomy was performed Bilateral renal ... al Journal of Translational Medicine 2011, 9:51 http://www.translational-medicine.com/content/9/1/51 Statistical Analysis Quantitative data are expressed as means ± SD Statistical analysis was ... groups and However, it was remarkably higher in groups and than in group at 24 h after IR injury Additionally, it was increased several folds in group as compared with that in groups and at 72 h and...
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Báo cáo sinh học: "The combined transduction of copper, zincsuperoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury" ppt
... Bax expression Bcl-2 and Bax expression was detected by Western blot as described in Materials and Methods (A) , and quantified by normalization to tubulin (B and C) Bcl-2/Bax ratio (D) was calculated ... myocardial ischemia- reperfusion injury CK CK-MB and cTnT are widely present in the cytoplasm of myocardial cells, and elevation of serum CK, CK-MB and cTnT are reliable indicators of myocardium injury ... experiments LYG made fusion protein and evaluated the apoptosis by Flow Cytometry YL and SYC analyzed the results and help writing the manuscript All the authors have read and approved the final manuscript...
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Báo cáo y học: "CXC-chemokine regulation and neutrophil trafficking in hepatic ischemia-reperfusion injury in P-selectin/ICAM-1 deficient mice" docx
... surgical operation, collection of samples, analysis and interpretation of the MPO and ALT data, as well as drafting the manuscript SD participated in the analysis of the cytokine data and the preparation ... occlusion The caudate and right lateral lobes, as well as the papillary and quadrate processes, retained an intact portal and arterial inflow and venous outflow to prevent intestinal venous congestion ... carefully dissected and the portal vein and hepatic artery supplying the median and left lateral lobes were then interrupted with an atraumatic vascular clamp (Accurate Surgical and Scientific Instruments...
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Báo cáo y học: " Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation" pdf
... injury, and that specific activation of A2 AAR, and not A1 AR, A2 BAR or A3 AR, has broad anti-inflammatory effects that attenuate lung IR injury Although we anticipated that lung injury and dysfunction ... proteincoupled adenosine receptor family which includes A1 , A2 A, A2 B and A3 Adenosine receptor sub-classification has shown specifically that activation of A2 AAR produces antiinflammatory responses and ... explanation, is that the A2 AAR does not normally play a significant anti-inflammatory role during acute lung IR injury It is plausible that activation of other adenosine receptors (A1 , A2 B and A3 ),...
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Báo cáo y học: "Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice" potx
... using imageJ 1.410 (National Institutes of Health, Maryland, USA) Data analysis All graphical values are expressed as means ± standard error of the mean, and to provide more descriptive data in ... present data as median (inter-quartile range) In the case of unequal variance, groups were analyzed using KruskalWallis one-way analysis of variance (ANOVA) on Ranks and subsequent multiple comparisons ... fraction (LVEF) was used to measure cardiac function at baseline, day and day post I/R Transthoracic echocardiography using a Vevo 770 cardiac ultrasound (Visualsonics, Toronto, Canada) while anesthetized...
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Báo cáo khoa học: " Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury" pps
... dna ylralullecartni seiceps tnadixo evitcaer secuder hcihw tnadixoitna sihT amsalp ni tnadixoitna elbulos-retaw niam a si dica cibrocsA yrujni R/I retfa detaulave erew ledom god eht ni IR dna ... gnirud aimeru fo sngis lacinilc on dah spuorg htob fo sgod llA stluseR tnacifingis yllacitsitats sa nekat erew 50.0 < p ta secnereffiD tset-t tnedutS dna AVONA yb detaulave saw sisylana lacitsitatS ... engiarfeD ,J liamecniP 296 -786 ,63 ,0002 locamrahP csavoidraC J yretra caili eninac otni lio naebyos fo noisufni yb derirapmi noitatalidosav cimehcsitsop sevorpmi dica cibrocsA T awakayaH ,T otI...
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Báo cáo khoa học: "Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation" pps
... dellif yart a ot devom dna ,avac anev laduac dna atroa eht ta demrofrep saw slessev eht fo noitceser dna noitagil ehT pmalc ralucsav citamuarta la te eeL li-eaJ 673 syendik eht ,tsartnoc nI )B & A4 ... .tnacifingis deredisnoc saw 10.0 ro 50.0< eulav A tset- s’tnedutS a yb neht dna )AVONA( sisylana serusaem detaeper yaw -2 yb dewollof ecnairav eht fo sisylana na gnisu dezylana saw atad ehT ... citoibitna na dna ,)aeroK ,snouH ;CS ,gk/gm 40.0( etaflus eniporta htiw detacidemerp era slamina eht ,tsaf thginrevo na retfA la te noitatnalpsnarT noitatnalpsnartotua yb dewollof puorg tnemtaert...
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Báo cáo y học: " Role of dopamine D2 receptors in ischemia/ reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes" potx
... μl/well) was added The plates were then agitated on a plate shaker The absorbance of each well was measured at 490 nm with a Bio-Rad automated EIA analyser (Bio-Rad Laboratories, Hercules, CA, USA) ... calcium channel gating by dopamine D2 receptors in frog pituitary menotrophs Ann NY Acad Sci 1993, 680:211-228 An J, Varadarajan SG, Camara A: Blocking Na+/H+ exchange reduces [Na+]i and [Ca2+]i ... centrifuged at 40,000×g for 30 at 4°C The supernatant was retained as the cytosolic fraction and analyzed by Western blot with a primary rat anti-cytochrome c monoclonal antibody and a secondary goat anti-rat...
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Báo cáo y học: "Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rat" pptx
... respectively Neuropathology: edema and axonal vacoulisation A sciatic nerve segment at cm long was harvested from each animal The sciatic nerves were osmicated, dehydrated, infiltrated, and embedded ... vacoulisation and edema were semi-quantitatively graded from to as follows: 0-normal, 1-mild, 2-moderate and 3-severe No distinction was made as to endoneurial, perivascular, or subperineurial edema A mean ... 95.0% CI of means Results Histopathologic changes Great cytoplasmic vacoulisation caused by proliferation and dilation of the rough and smooth endoplasmic reticulum and golgi apparatus was observed...
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Báo cáo y học: "Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits" docx
... Placing a heating pad under the animal and exposing it to a heat lamp maintained animal body temperature min) intra-aortically via the Peripheral Dilatation Catheter line, by the onset of reperfusion ... dark) and incubated for at room temperature The absorbance of the mixture at 620 nm was converted to protein mg from a 00.05 mg BSA standard curve (against appropriate sample and reagent blanks) A ... aorta Ann Thorac Surg 2001, 72:699-707 Barboi C, Perruzi TW: Acute spinal cord injury management and surgical consideration: Acute medical management of spinal cord injury: Pharmacologic management...
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Báo cáo y học: " Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation" ppt
... KW, Pullmann K, Obed A, Schlitt HJ, Beham A: Adenoviral bcl-2 transfer improves survival and early graft function after ischemia and reperfusion in rat liver transplantation Transplantation 2005, ... Huang J, Nakamura K, Ito Y, Uzuka T, Morikawa M, Hirai S, Tomihara K, Tanaka T, Masuta Y, Ishii K, et al.: Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation ... nephropathy in rats Transplantation 2005, 79:655-661 23 Furuichi K, Wada T, Iwata Y, Kitagawa K, Kobayashi K, Hashimoto H, Ishiwata Y, Tomosugi N, Mukaida N, Matsushima K, et al.: Gene therapy Lutz...
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Báo cáo y học: " tài: Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation" potx
... KW, Pullmann K, Obed A, Schlitt HJ, Beham A: Adenoviral bcl-2 transfer improves survival and early graft function after ischemia and reperfusion in rat liver transplantation Transplantation 2005, ... Huang J, Nakamura K, Ito Y, Uzuka T, Morikawa M, Hirai S, Tomihara K, Tanaka T, Masuta Y, Ishii K, et al.: Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation ... nephropathy in rats Transplantation 2005, 79:655-661 23 Furuichi K, Wada T, Iwata Y, Kitagawa K, Kobayashi K, Hashimoto H, Ishiwata Y, Tomosugi N, Mukaida N, Matsushima K, et al.: Gene therapy Lutz...
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Báo cáo y học: "Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts" pps
... mM/L CaCl2, 25 mM/L NaHCO and 11 mM/L C H 12 O The heart was attached to a Lagendorff apparatus via an aorta for retrograde perfusion with KH buffer maintained at 37°C and pH7.4 and saturated ... plant used in this study Author details School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur, Tamil Nadu, India 2SASTRA University, Thirumalaisamudram, Thanjavur, ... Rastaldo R, Pagliaro P: Cardioprotection: a radical view of free radicals in pre and postconditioning Biochim Biophys Acta 2009, 1787(7):781-793 Gosh D, Anandkumar A: Anti-inflammatory and analgesic...
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Role of cyclic AMP signalling mechanisms in heart protection against ischemia reperfusion injury
... Epac Activator 8-Br-cAMP Significantly Reduces Infarct Size A Control 8-Br-cAMP-AM B Cell-pemeable cyclic AMP analogue 8Br-cAMP-AM which activates both PKA and Epac effectively protects heart against ... of hearts with a PKA activator (isoproterenol) and a PKC activator (adenosine) results in an extraordinary cardioprotective effect during normothermic (37°C) ischaemia and reperfusion Khaliulin ... HKII ROS PKC Acknowledgements Doctor Andrew James Doctor Mark Bond Professor Saadeh Suleiman Professor Andrew P Halestrap Labs of Professor Saadeh Suleiman and Professor Andrew Halestrap ...
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The role of adenosine, adenosine receptors and transporters in the modulation of cell death
... studies of AIA in HeLa 185 cells xv ABBREVIATIONS AC adenylyl cyclase Ac-DEVD-AMC N-acetyl-Asp-Glu-Val-Asp-AMC Ac-DEVD-CHO N-acetyl-Asp-Glu-Val-Asp-CHO Ac-IETD-AFC N-acetyl-Ile-Glu-Thr-Asp-AFC Ac-IETD-CHO ... of ATP, ADP, AMP and adenosine, selective antagonism of the effects of adenosine by methylxanthines, activation of adenylate cyclase by adenosine and stimulation of prostaglandin synthesis by ATP ... Signal Transduction of A1 Receptors The adenosine/ P1 receptor family comprises A1 , A2 A, A2 B and A3 adenosine receptors, identified by confirming data from molecular, biochemical and pharmacological...
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Hydrogen sulfide produces cardioprotective effects against ischemia reperfusion injury via regulation of intracelluar PH
... Bian’s lab for their help and support for these two and a half years I am especially grateful to Dr Hu Lifang and Ms Neo Kay Li for their contribution in the intracellular pH part and ion exchanger ... from long-chain fatty acids and their acyl-CoA equivalents During ischemia reperfusion, the oxidation of fatty acids slows down, which results in the accumulation of acyl-CoA and KATP channel opening ... hearts, and to investigate whether this mechanism involves the activation of PI3K/Akt pathway and/ or protein kinase G (PKG) 13 CHAPTER MATERIALS and METHODS 2.1 Isolation of rat ventricular...
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