... minutes of short ischemia with minute's intervals), and then hours ofischemia with hours ofreperfusion Part 2: Long time effetcs of I/R and IP Group 1- I/R with long duration (7dR):4 hours ofischemia ... and days ofreperfusion A total of 70 rats were used in the study The study was divided into two part Part included the biochemical examination of Ischemia, I/R and I/R+IP on sciatic nerves of ... nerve of rat is seen (sham group), Hematoxylen esozine 40× magnification days) of reperfusion, but also much more extended time (up to 42 days) ofreperfusion [18] Between days and 14 days of reperfusion, ...
... of PEP-1-SOD1 and/ or PEP-1-CAT in rat myocardium and ischemia- reperfusioninjury To observe whether transduced PEP-1-SOD1 and PEP-1CAT protect myocardial ischemia- reperfusioninjury in Page of ... both of PEP-1-SOD1 and PEP-1-CAT to rats with myocardial ischemia- reperfusioninjury CK CK-MB and cTnT are widely present in the cytoplasm of myocardial cells, and elevation of serum CK, CK-MB and ... PEP-1-SOD1 and PEP-1-CAT cooperatively protected heart against ischemia- reperfusioninjury by removing OFR Ischemia- reperfusioninjury induces myocardial apoptosis [28,29] OFR produced during the reperfusion...
... ischemic injuryand improving kidney function from acute damage through engraftment of MSCs in both glomerular and tubular structures, regeneration of tubular epithelium, augmentation of paracrine and ... apoptosis, and suppressing oxidative stress in this experimental setting of acute kidney IR injury The cause of discrepancy between mRNA and protein expressions of HO-1 on both day and day after ... expressions of NQO1, GR, and GPx, three anti-oxidative indicators, were remarkably lower in group than in groups and 3, and notably lower in Figure Histopathological scoring of ischemia- reperfusion...
... reliability of a method for sciatic nerve ischemia- reperfusioninjury Microsurg 2007, 27(3):206-207 Iida H, Schmelzer JD, Schmeichel AN, et al.: Peripheral nerve ischemia: reperfusioninjuryand fiber ... studies showing IFD and profound axonal edema at days Iida [4] also reported a third phase of fiber regeneration with only minimal edema and fiber debris at 28 and 42 days of reperfusion; but, ... JD, et al.: Effect ofischemiaandreperfusion in vivo on energy metabolism of rat sciatic-tibial and caudal nerves Exp Neurol 1991, 114:315-320 Publish with Bio Med Central and every scientist...
... mechanism of spinal cord injury after ischemia- reperfusion consists of progressive loss of motor neurons accompanied with a steady decline of motor function [3] The complexity of this mechanism is ... occlusion (phase 5) and at the onset ofreperfusion (phase 6) Sedation was maintained by intravenous administration of Propofol 1% (PROPOFOLđ, Astra Zeneca, Chershire, UK), (0.6 mg/kg), and Fentanyl ... failure of aerobic energy metabolism and lactate accumulation, b) activation of mitochondrial and cytoplasmic nitric oxide synthase (NOS) and production of nitric oxide [25], c) activation of phospholipase...
... manifestation of the reperfusioninjury Idstrom [12] utilised a period of 2, and h cold 25°C hind limb ischaemia in rats and one hour reperfusion to measure damage and recovery of adenine nucleotides ... contribute to ischaemia reperfusioninjuryof fast-, mixed fast/ slow- and slow-twitch muscle types Viability of these Page of (page number not for citation purposes) Journal of Inflammation 2004, ... because of the wide variety of IR models in use In particular, there is a great deal of variation in the period of ischaemia, the muscle temperature during ischaemia and the period of reperfusion...
... Wild-type mouse after 90 minutes ofischemiaand h of reperfusion, (D) P/I null mouse after 90 minutes ofischemiaand h ofreperfusionischemia followed by and 15 h ofreperfusion were significantly ... and E) Wild-type mice subjected to 90 minutes ofischemia followed by and 15 h ofreperfusion respectively; (D and F) P/I null mouse subjected to 90 minutes ofischemia followed by and 15 h of ... euthanized after and 15 h ofreperfusionand the Page of 10 (page number not for citation purposes) Journal of Inflammation 2007, 4:11 blood and liver tissue were collected and processed, as...
... enzymes from the assault ofischemiareperfusioninjury (Table 4) Conclusion The ethyl acetate extract of Desmodium gangeticum root protects the myocardium against ischemia- reperfusioninduced damage ... made up to ml by adding distilled water and kept in a water bath at 100°C for hour After cooling, ml of distilled water and ml of a mixture of n-butanol and pyridine (15:1 v/v) was added The mixture ... minutes and remixed The absorbance of the organic layer was measured at 532 nm The percentage inhibition of lipid peroxidation was determined by comparing results of the test compounds with those of...
... point in each group were studied Ischemia- reperfusionof the LAD An open-chest model of I/R using ligation andreperfusionof the LAD was modified from Michael and colleagues [36] Mice were anesthetized ... following ischemia/ reperfusionand persists throughout our seven day observation period Figure ing I/R of the of left Western blot LAD ventricular OTR levels at baseline and day following I/R of the ... regulation of vasopressin receptor subtype in the heart as a result of I/R Expression of V1R, V2R, and OTR in the heart was assessed in four mice per group at baseline and at day following I/R of the...
... ROS PKC Acknowledgements Doctor Andrew James Doctor Mark Bond Professor Saadeh Suleiman Professor Andrew P Halestrap Labs of Professor Saadeh Suleiman and Professor Andrew Halestrap ... activates both PKA and Epac effectively protects heart against ishaemia /reperfusion injury PKA and Epac act synergicaly in the cardioprotective effect of cAMP Scheme of Signal Transduction of the cAMPInduced ... 2007;581:1147-61 Study of the signalling mechanisms of cardioprotective effect of temperature preconditioning have revealed that this intervention is mediated by consecutive activation of PKA and PKC as...
... myocytes injury induced by ischemiaandreperfusion for 10, 30, and 60 D, treatment with NaHS (100 μM) and KR (KR-32568; μM) alone or a combination of both protected myocytes against ischemia/ reperfusion ... 762.92% ±148.21% of the value before ischemia, while LVeDP of control group at 15 ofreperfusion remained at 1273.32% ± 232.00% of the value before ischemia Our data suggest that hearts of control ... 3.03% of preischemia value at the first 15 ofreperfusion These data indicate that NaHS treatment significantly restored the contractility and compliance of hearts subjected to ischemia/ reperfusion...
... remodeling after ischemia/ reperfusioninjury Particularly the matrix metalloproteinases 2, 3, and have been shown to influence tissue repair In experimental models of I/R injury an inhibition of MMPs ... itself, the difficulty to assess organ viability during cold storageand the development of I/R injury all make passive cold storage difficult for future improvements of strategies Donor preconditioning ... mentioned problems of cold storage, I/R injury, cold injuryand problems to assess graft viability during storage [74] Normothermic preservation has not only the potential to preserve organs but also...
... remodeling after ischemia/ reperfusioninjury Particularly the matrix metalloproteinases 2, 3, and have been shown to influence tissue repair In experimental models of I/R injury an inhibition of MMPs ... itself, the difficulty to assess organ viability during cold storageand the development of I/R injury all make passive cold storage difficult for future improvements of strategies Donor preconditioning ... mentioned problems of cold storage, I/R injury, cold injuryand problems to assess graft viability during storage [74] Normothermic preservation has not only the potential to preserve organs but also...
... and drafted the manuscript JL and ILK helped with the analysis and interpretation of the data VEL helped in conception and design of the experiments, analysis and interpretation of the data and ... Jones ML, Deeb GM, Bolling SF, Ward PA: Pattern ofinjuryand the role of neutrophils in reperfusioninjuryof rat lung J Surg Res 1995, 58:713-718 Bando K, Paradis IL, Similo S, Konishi H, Komatsu ... activation of A2AAR on resident lung cells would attenuate pulmonary injuryand dysfunction after IR despite the absence of circulating platelets and leukocytes from blood reperfusion Methods Animals and...
... late increase of neutrophils after hour ofischemiaand hours ofreperfusion • Significant apoptosis and lung oedema in the absence of necrosis after hour ofischemiaand hours ofreperfusion 12 ... after hour of warm ischemia followed by 30 to hours ofreperfusion A first peak was shown after 30 ofreperfusionand a second peak after hours ofreperfusion Furthermore, after hours of reperfusion, ... blood/air barrier after only 30 ofreperfusion Apoptotic cells appear after hours ofreperfusion in a warm model ofischemiareperfusionand after 6–9 hours ofreperfusion in a transplantation...
... consequences of lung ischemia- reperfusioninjuryand low-pressure ventilation J Surg Res 2009, 153:295-301 Bittner HB, Binner C, Dahlberg P, Mohr FW: Reducing ischemia- reperfusioninjury in clinical ... Parenchyma after IschemiaReperfusion (IR) Injury Notably higher protein expressions of TNFa (A) and NF-B (B) in IR group than in normal control and IR + ADMSC groups, but lack of difference between ... percentages of all EPC surface markers were similar between day and day 14 of cell culture Additionally, the percentages of MSC surface markers of CD45+ and CD271+ cells did not differ between day and...