Molecular analysis of the p14 ARF hdm2 p53 regulatory pathway in breast carcinoma

... representation of the cell cycle, showing the role of p53 at the G1/S checkpoint Figure 10 Schematic representation of the p1 4ARF- hdm2- p53 regulatory pathway The binding of p53 to hdm2 results in inactivation ... 1.5.2 The role of p53 at the G1/S checkpoint of the cell cycle 22 1.5.3 Inactivation of p53 23 1.5.4 Significance of p53 in...

Ngày tải lên: 17/09/2015, 17:20

... 5¢-CATCTTGAAAGTCGGTGCGGGAGAAGCAA CACAATGC-3¢ (the reverse primer was the complementary sequence); pCA(E45 7A) forward primer, 5¢-CATCTTGA AAGTCGGTAAGGGAGCAGCAACACAATGC-3¢ (the reverse primer was the ... Simoes et al ˜ Cardosin A associates with phospholipase Da A Fig Cardosin A interacts with the C2 domain of PLDa Pull-down assays for cardosins A and B were per...

Ngày tải lên: 30/03/2014, 11:20

... loading Results BPA induces dose dependent apoptosis in acute myeloid leukemia cells To understand the potential role of BPA in biological systems of leukemias we tested the action of BPA in three ... activity of these compounds [17,18] In the present manuscript, we decided to investigate the effects of different doses of BPA on acute myeloid l...

Ngày tải lên: 18/06/2014, 15:20

... and Schroer, 2000) There are two types of kinesin, kinesin-1 and kinesin-2 Kinesin-1 is found to be involved in the transport of various organelles including Golgi complex (Lippincottschwartz et ... structure of the host genome, thus facilitating the inserting of T-DNA 1.4 The response of the host cells to Agrobacterium infection Similar to other pathogens, Agrobacter...

Ngày tải lên: 09/09/2015, 10:08

... attainable size, big and long fins of the RG1 and the intense colouration of the MG One of the shortfalls of the hybrid is the large variation of phenotypes produced in their offsprings which is common ... particularly the subfamily Osteoglossinae We hope that our work will enhance the understanding of the evolution of the breeding biology of teleost, a...

Ngày tải lên: 14/09/2015, 08:49

... adapter to bring the VirE2 to the importin Once inside the nucleus, VIP2 may target the T- DNA to areas of chromatin that are being actively transcribed, so that the T- DNA can integrate into the ... The natural host of A tumefaciens is the plant cell The formation, transfer and Integration of the T- DNA into the plant cell requires three genetic compone...

Ngày tải lên: 13/10/2015, 16:50

... Trk1- Seq-F1 ACAAAGACAGCACCAACAGA Trk1- Seq-R1 GAAGTAGTGAACCGCGATAA Trk1- Seq-F2 TGGATCGTGCAATTATCTTG Trk1- Seq-R2 AAGGCGATTAAGTTGGGTAA 26 2.2 DNA manipulation 2.2.1 Transformation of plasmid DNA ... seelection marrker 25 Table 2.5: List of primers Primer Sequence (5’-3’) GFP1 GATAAGGCAGATTGAGTGGA GFP2 AAAGATGACGGTAACTACAA TO105-2F CTAGGGATCCGCCACCATGCATTTTAGAAGAACGAT TO105-2R CTAGG...

Ngày tải lên: 16/10/2015, 11:57

... 17 AN ANALYSIS OF THE INAUGURAL ADDRESS BY G. W BUSH IN THE U. S PRESIDENTIAL ELECTION 2004 FROM A PERSPECTIVE OF D .A DATA ANALYSIS AND DISCUSSION 3.1 Analysis of data 3.1.1 Lexical choice By referring ... 14 AN ANALYSIS OF THE INAUGURAL ADDRESS BY G. W BUSH IN THE U. S PRESIDENTIAL ELECTION 2004 FROM A PERSPEC...

Ngày tải lên: 18/12/2013, 10:08

... that the amino group at carbon of the guanine ring may interact with the side chain of Glu309, whereas the carbonyl group at position of the guanine ring may interact with the hydroxyl group of the ... structures of the EhPGK obtained using the modeller program (Fig S1), it was found that the only difference in the amino acids that bind the purine ring was...

Ngày tải lên: 16/03/2014, 01:20

... the only protein with which one can biochemically assay both DNA endonuclease and RNA maturase activities in vitro This investigation provides the first step in the study of the relationship between ... stringent concentration of KCl, there was a correlation between inhibition of endonuclease activity and inhibition of splicing activity indicating that R...

Ngày tải lên: 17/03/2014, 10:20

... is the target delay and ε is the probability of exceeding it On the other hand, in multiuser communications the capacity of the channel is no longer fully characterized by a single number Instead, ... , is obtained as the sum of the individual user rates, each of them with its own delay constraint: U CDt , = u=1 Ru t ,ε , D (22) with Dt and being the vector...

Ngày tải lên: 21/06/2014, 11:20

... BRLF1 gene from multiple tissues Based on the phylogenetic tree, we identified distinct subtypes of BRLF1 gene in the specimens of Northern China Two subtypes, BR1-A and BR1-C, were dominant in the ... TWs The frequency of BRLF1 subtypes in EBVaGCs, NPCs, and TWs of healthy donors was summarized in Table Fisher’s exact test was used to determine the dif...

Ngày tải lên: 12/08/2014, 02:20

... diversity (Shannon's Figure intensity and distribution of positively selected sites in the C2, V3 and C3 regions along the course of HIV-2 infection Frequency, Frequency, intensity and distribution of ... evolution of the HIV-2 env gene In the present study we analyze, for the first time, the molecular evolution of the env C2V 3C3 regions...

Ngày tải lên: 13/08/2014, 05:21

... doi :10 .11 86 /14 23- 012 7 -17 -77 Cite this article as: Yee and Sim: High cell density and latent membrane protein expression induce cleavage of the mixed lineage leukemia gene at 11 q23 in nasopharyngeal ... High cell density induces apoptosis and subsequent cleavage of the MLL breakpoint cluster region (bcr) To investigate the role...

Ngày tải lên: 10/08/2014, 05:21

... measure the mobility of the components in the PGCs The medaka embryo was peeled off the chorion, and the segment containing the part of PGCs was excised for observation by microscopy and FCS ... dynamic nature of the nuage Schematic diagram of the preparation of PGCs of medaka specimen (A) OlvasGFP was expressed in the medaka PGC at stage 24 and...

Ngày tải lên: 18/02/2014, 16:20