Báo cáo y học: "Destabilization of the TAR hairpin leads to extension of the polyA hairpin and inhibition of HIV-1 polyadenylation" pptx
Ngày tải lên: 13/08/2014, 05:21
Báo cáo khoa học: Cellular and molecular action of the mitogenic protein-deamidating toxin from Pasteurella multocida pptx
... understanding of the structural and biochemical basis of the effects of these toxins on vari- ous host signaling pathways have provided interesting and sometimes surprising insights into the molecular mechanisms ... is the detection of the modification, which involves the detection of a molecular mass change of 1 Da in a relatively large protein substrate (20–45 kDa). Another challenge is the development of ... toxins. Although the precise localization of the domains responsible for receptor binding and translocation activity remains unclear, these domains are located in the N-terminus of each of these toxins and...
Ngày tải lên: 22/03/2014, 15:21
Báo cáo khoa học: Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii ppt
... hold the b-sandwich in position. With the exception of four a-helices and t wo pairs of short b-strands, the rest of the protein consists almost entirely of loops connecting the b-strands. The ... concave surfaces. The convex and concave sheets o f the b-sandwich are composed of seven b-strands. Many of the side-chains in the b-sheets are hydrophobic, and interactions between these residues appear ... is the predominant product of hydrolysis and increases in concentration as the reaction proceeds [21]. The exo-loop of 1CEL (amino acids 243–256) forms the roof of the active site tunnel at the...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: Molecular cloning of the ecdysone receptor and the retinoid X receptor from the scorpion Liocheles australasiae pot
Ngày tải lên: 30/03/2014, 04:20
A study of semantic and pragmatic features of the adjective warm and its vietnamese equivalents
Ngày tải lên: 26/11/2013, 13:21
Tài liệu A Dissertation on the Medical Properties and Injurious Effects of the Habitual Use of Tobacco pptx
... capable of giving strength to the weary, vivacity to the stupid, and wisdom to men void of understanding; capable of soothing the sorrows of the afflicted, of healing the wounds of the spirit, and ... healthy condition of the vessels belonging to the membranes of the socket, with the condition of which, the state of the tooth is closely connected."] Having gone through with an examination of the physical ... towards them. Hence the Methodists interdicted the common use of tobacco with that of ardent spirit, in the infancy of their society; thereby evincing a just sense of the self-denial, decency, and...
Ngày tải lên: 17/02/2014, 22:20
Tài liệu Báo cáo Y học: Structure of the O-polysaccharide and classification of Proteus mirabilis strain G1 in Proteus serogroup O3 potx
... migrating bands of three LPS (without R14) and fast migrating bands of P. mirabilis G1, O 28, and R14 LPS (Fig. 5A). These bands correspond to high- and low -molecular -mass LPS species consisting of the ... migrating bands of all LPS tested and slow migrating bands of P. mirabilis S1959, G1, and O28 LPS, the banding patterns being clearly different (Fig. 5B). These findings together showed that the epitope ... O-polysaccharide p art of LPS. The serological relatedness of P. mirabilis G1 and S 1959 correlated with the similarity of the chemical structures of their O-polysaccharides (Fig. 3). Therefore, it is...
Ngày tải lên: 21/02/2014, 15:20
Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
... RPAP. The size o f the interaction surface between the peptide and the non binding bottom of the Fab is 173 A ˚ 2 which c orresponds to about 36% of the interaction of the full peptide with the ... MUC-1; binding epitope. The extracellular part of the epithelial glycoprotein MUC-1 consists of tandem repeats of 20 amino acids (PDTRPAPGSTAPPAHGVTSA, where the start of the tandem repeat peptide ... e crystalcellthathaveadistanceof4A ˚ or less to the ligand. The C-terminal part of the pe ptide (RPAP) has clo se contacts to the n ext protein in the crystal cell and is therefore stabilized on the surface o...
Ngày tải lên: 21/02/2014, 15:20
Research " THE RATE OF RETURN TO EDUCATION AND THE GENDER EARNINGS DIFFERENTIAL : A COMPARISON OF THE UNITED STATES AND THE REPULIC OF IRELAND " ppt
Ngày tải lên: 16/03/2014, 03:20
Báo cáo khoa học: Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis pot
... mutagenesis of CL1 and CL2 site residues of tACE and ACE2 The residues surrounding the chloride ion at the CL1 and CL2 sites of tACE and ACE2 are shown in Fig. 1. In tACE, the residues that coordinate the ... that in the absence of NaCl and 3.2- fold less than that at 100 mm NaCl. Effects of CL1 and CL2 site mutations on the chloride sensitivity of tACE and ACE2 In order to observe the effects of the ... [23]. The CL2 chloride site is absent in ACE2 as a result of substitution of the tACE residues Pro407 and Pro519 with Glu398 and Ser511, and the resulting projection of their side-chains into the...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: Structures of the O-polysaccharides and classification of Proteus genomospecies 4, 5 and 6 into respective Proteus serogroups ppt
... including O-polysaccharides of Proteus [16]. Studies of the O-polysaccharides of Proteus genomo- species 5 and 6 and the comparison of the correspond- ing 13 C NMR spectra indicated that they are identical to those of ... consistent with the western blot data showing the absence of any common epitope on the O-polysac- charides (Fig. 4B). Based on the results of serological studies and the uniqueness of the O-polysaccharide ... analysis of the acetylated methyl glycosides showed the presence of GalA. GLC analyses of the acetylated (S)-2-(+)-butyl glycosides demonstrated the d configuration of Glc, GlcN, GalN, and GalA. The...
Ngày tải lên: 16/03/2014, 23:20
Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
... conformation and hydrogen bonding network of the pterin cofactor in the three structures. Superpositions of the binary and ternary complexes of hPAH onto the crystal structure of the ligand-free ... that of the ligand-free rPAH containing the regulatory and catalytic domains [19] the catecholamine main-chain is also Fig. 4. Stereo view of the site of interaction between the pterin cofactors and ... required for the cofactor inhibition of phosphorylation (data not shown). The molecular basis for the negative modulatory effects of the pterin cofactor and dopamine binding to wt-hPAH and their reversal...
Ngày tải lên: 17/03/2014, 09:20
Báo cáo khoa học: Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana pptx
... sequencing of the entire insert was carried out and was in complete agreement with the expected sequences. The theoretical masses of the products TyrAAT1 and TyrAAT2 were determined to be 68.5 kDa and ... than for their arogenate substrate. This strong feedback inhibition arises from the necessity of the plant cell, to regulate the flux of arogenate between the synthesis of tyrosine and that of phenylalanine. ... for understanding the partition of the carbon flux between the different end products. The present study is the first to report the purification and detailed kinetic characterization of A. thaliana...
Ngày tải lên: 17/03/2014, 11:20
Retrieval of the source location and mechanical descriptors of a hysteretically-damped solid occupying a half space by full wave inversion of the the response signal on its boundary doc
... are the cartesian coordinates of the position of the receiver on the ground and (0, 0) the position of the emitter, also on the ground, of the probe signal. The present study is restricted to the ... the MNI of the RM is chosen to be the same as the MNI of the SM. In this case, when the values of all the parameters of the set P are strictly equal to their counterparts in the set p and the values ... C=D/T, and that of the related problem of the retrieval of the position of the source from T is D=CT. The type of questions we address in the present investigation, in which the liquid is a solid...
Ngày tải lên: 18/03/2014, 01:21
Báo cáo khoa học: Genomic structure and expression analysis of the RNase j family ortholog gene in the insect Ceratitis capitata pptx
... organization of the Cc RNase gene and its derived mRNA isoforms. The rectangles represent the exons and the horizon- tal bold lines the introns. The black parts of the rectangles show the protein-coding ... (AAUAAA). The first signal (AAUAUA) is located just 19 bp upstream of the poly(A) tail of the shorter transcript and the second one is located 46 bp upstream of the poly(A) tail of the alternative transcript. ... (SpuUn_WGA56223_2:75333–76952) and Nematostella vectensis (NW_001834409:c1450413–1449631). The numbers above the boxes indicate the size of the exons, and those below the lines indicate the size of the introns....
Ngày tải lên: 23/03/2014, 06:20
Báo cáo khoa học: Hatching enzyme of the ovoviviparous black rockfish Sebastes schlegelii – environmental adaptation of the hatching enzyme and evolutionary aspects of formation of the pseudogene docx
... cycles of PCR, sufficient expres- sion of the SsHCE1 and SsHCE2 genes was detected, and the band intensity of SsHCE2 tran- scripts was about half that of SsHCE1. For the wSsLCE gene, the 33 cycles of ... was found in the ovarian fluid carrying the embryos immediately before the hatching stage. Two kinds of HCE were partially purified from the fluid, and the relative molecular masses of them matched ... fertilize their eggs from the beginning to the middle of April in the sys- tem, the developing embryos were ordinarily collected by canulation into the ovary from the end of April to the mid- dle of...
Ngày tải lên: 23/03/2014, 07:20