Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 2
Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 2
... targeted-disruption mice for both Cidea and Cideb will is reported The biochemical and physiological analysis of Cidea knock out mice (Cidea- /- or Cidea null) are thus the foci of this thesis 30 ... 56 CIDE-C Cidea Cideb FSP27 116 135 20 3 23 9 Figure 4A Schematic structure of mouse Cidea, Cideb, FSP27 and DFF45 Chapter The amino acid sequence alignments of...
Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 6
... K., Idzerda, R L., and McKnight, G S (19 96) Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A Nature 382, 62 2 -62 6 Desautels, M., and Dulos, R A (1988) ... activities Cidea null mice have a hyperactive thermogenesis and increased lipolysis in response to cold and with increasing age compared to wild type mice Notably,...
Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 5
... liver sections of wild type and Cidea- null mice 80 Chapter ND HFD +/+ -/- Figure 21 Light micrograph of liver sections of 9-month-old Cidea+ /+ and Cidea- /mice The mice were fed with standard chow ... the Cidea null mice 84 Chapter A C B D 70 -/+/+ VO2(ml/kg/min) 65 60 55 50 45 40 35 30 60 120 180 240 300 360 420 480 54 0 600 Time(mins) Figure 25 Indirect calori...
Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 4
... translation of Cidea gene was thus successfully inactivated in Cidea- /- mice (or Cidea null mice) The first generation of heterozygous mice breeding yielded 14 (+/+), 31(+/-) and 15(-/-) mice, thus ... (Evans and Kaufman, 1981), and most knockout mice are created from ES cells of this strain The coat color of 129 strains are agouti (light brown), and the use...
Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant 3
... statistical software (Graphpad software Inc.) 2.9 Plasmid construction, expression of UCP1 3 and Cidea in yeast and measurement of Mitochondria Potential Mouse UCP1 cDNA was PCR amplified from cDNAs of ... the manufacturer’s instructions 2 .3. 4 Mapping of Cidea and Cideb locus and construction of the targeting vector After the screening, one Cidea genomic clone and...
Physiological roles of CIDEs CIDEA deficient mice exhibit lean phenotype and are obesity resistant
... PHYSIOLOGICAL ROLES OF CIDES: CIDEA DEFICIENT MICE EXHIBIT LEAN PHENOTYPE AND ARE OBESITY RESISTANT ZHOU ZHIHONG (M.Sc Tsinghua Univ.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... (2003) Cidea deficient mice have lean phenotype and are resistant to obesity Nat Genet 35(1): 49-56 Chen, Z., Guo, K., Toh S.Y., Zhou, Z., Li, P (200...
Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... and that vincristine inhibits the high affinity DNP-SG transport in the presence but not in the absence of GSH [12,45,46] Thus the effect of vincristine on the cGMP uptake was also tested in the ... these and cGMP block low affinity [3H]DNPSG transport in human erythrocytes and so the low affinity transport of DNP-SG and the transport of c...
Báo cáo y học: " Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis" doc
... Characterization of cathepsin K overexpression in the lungs of mice We initially characterized cathepsin K overexpression in the lungs of transgenic mice compared to wild-type mice Analysis of cathepsin K mRNA ... bleomycin Cathepsin K Cathepsin K actin Actin D Lung tissue E BAL supernatant WT Cath K tg WT Cath K tg bleomycin bleomycin Cathep...
Investigation of the roles of two rac1 effectors phosphatidylinositol 5 kinase 1a and p21 activated kinase 1 in insulin secreting cells
... INVESTIGATION OF THE ROLES OF TWO RAC1 EFFECTORS PHOSPHATIDYLINOSITOL- 5 KINASE Iα AND P 21- ACTIVATED KINASE IN INSULINSECRETING CELLS ZHANG JIPING (B.Sc., SICHUAN University) A THESIS SUBMITTED ... PIP5K-Iα in insulin secretion in INS -1 cells 11 1 4 .1. 3 Implication of PIP5K-Iα in PIP2 production in INS -1 cells 1 15 4 .1. 4 Role of...
báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
... safety and feasibility of combining vaccination with MVA expressing 5T4 and highdose IL-2 in patients with metastatic RCC The trial was Page of 11 (page number not for citation purposes) Journal of ... Merino MJ, Rosenberg SA: Randomized Study of High- Dose and Low -Dose Interleukin-2 in Patients With Metastatic Renal Cancer J Clin Oncol 2003, 21:...
Effect of radiation on the sensori neural auditory system and the clinical implications 2
... number of clinical issues related to the effects of radiation on the sensori- neural audiory system Do we know enough about these effects, so as to offer feasible solutions to the important clinical ... numbers of patients Prospective studies on the long-term effects beyond year after irradiation, have not been done 2. 3 Combined effects of radiation and CD...
báo cáo hóa học:" Unsaturated phosphatidylcholines lining on the surface of cartilage and its possible physiological roles" potx
... contributions YC contributes to the conception and design, the conduction of the experiment, the collection, analysis and interpretation of data, the drafting the manuscript and acquisition of ... also synthesized and secreted in other parts of the body such as in the peritoneal cavity and joints [4,5], where its adsorption on the surfaces of tissues...
Báo cáo y học: "Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice" pptx
... statistically significant Results Effect of leptin and leptin receptor deficiency on joint swelling in zymosan-induced arthritis Arthritis was induced in ob/ob and control +/? C57BL/6 mice by injecting ... however, in the latter group they remained significantly The results of the present study indicate that resolution of joint swelling in ZIA was delayed in leptin defic...
báo cáo khoa học: "Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice" doc
... have examined the effects of manipulating Egr-1 in tumors Overexpression of Egr-1 delivered via adenovirus resulted in reduced tumor growth and diminished expression of angiogenic factors in a mouse ... slower growth in Egr-1- /- mice Mig has previously been shown to slow the growth of tumors in various models In a mouse model of Burkitt's lymphoma, intr...
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