Particle development for drug delivery

... PARTICLE DEVELOPMENT FOR DRUG DELIVERY LEE CHIN CHIAT B Sc (Pharm) (Hons) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT ... Rationale for the Choice of Equipment and Method Employed 112 A1.1 Rationale for Choosing FB Hammer Mill 112 A1.2 Rationale for Choosing Laser Diffraction for Particle Sizing 113 A1.3 Rationale for ... account for the diff...

Ngày tải lên: 17/09/2015, 17:19

... polypeptide -drug conjugates [PGA-Doxorubicin (Dox)] The researchers also investigated the applicability of thick-walled polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded ... drug delivery They prepared drug- loaded polymer nanocapsules according to the outlined approach by preconjugating a model anticancer drug (Dox) to a model polyme...

Ngày tải lên: 22/06/2014, 01:20

... joint Finally, we studied the efficacy of microparticles containing DXM and SPIONs (referred to as complete microparticles) as an anti-inflammatory drug delivery system in an experimental model ... demonstrated by the preliminary study and considering the fact that they can incorporate more DXM and SPIONs than the 1-μm microparticles, we chose the 10-μm micropar...

Ngày tải lên: 09/08/2014, 14:20

... reduced drug loss and possible controlled drug release It is widely known that poly (lactic-co-glycolic) acid (PLGA) is able to sustain drug release for a prolonged period of time and is therefore ... time -controlled and/ or target -controlled 22 INTRODUCTION delivery of drug In time -controlled delivery, the drug is released in a pre-determined rate while in tar...

Ngày tải lên: 13/09/2015, 20:39

... DESIGN AND FABRICATION OF MICRONEEDLES FOR DRUG DELIVERY JI JING ( B.Eng.,M.Eng., NWPU, CHINA) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MECHANICAL ... Many of fabricated microneedles are designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local d...

Ngày tải lên: 14/09/2015, 11:17

... concentration on the surface of the film and finally ks is the desorption rate constant Substituting known values and by fitting the experimental data with the mathematical model of Eq 1, the h value ... bulk, C10 is the concentration inside the gel, S and V1 are, respectively, the surface and the volume of film, V2 is the volume of the bulk, h is the mas...

Ngày tải lên: 22/06/2014, 00:20

... = 100 μm intranasal drug delivery helps in improving the efficacy of drug by assisting in its lung delivery and biodistribution The PLGA- PEGPS341 provides controlled and targeted drug delivery ... drug- delivery therapeutics for CF and other airway diseases like COPD and asthma The nanodrug delivery system here provides controlled and sustained PS-34...

Ngày tải lên: 11/08/2014, 00:22

... development of a non- aqueous gel system intended for topical delivery of moisture-sensitive drugs Both the non- aqueous hydrophilic and lipophilic gel systems were formulated The hydrophilic gels ... Model drug 38 I-D3 Formulation of non- aqueous MH gel 40 I-D3.1 Solvents and gelling agents 42 iii Table of Contents I-D3.1.1 Non- aqueous hydrophilic gel s...

Ngày tải lên: 15/09/2015, 17:10

... thinking Because of the synthesis impairment, acetylcholine is decreased in the neurons in the Alzheimer disease brain, leading to the incapability of learning, memory, and thinking Providing ... there are great possibilities for them to be used in the construction of drug delivery systems in not too long a time The functionalization of CNTs used in the...

Ngày tải lên: 20/06/2014, 22:20

... the rate of Cu release (see Discussion) In vitro toxicity of CuCNPs in HeLa cells The in vitro toxicity of CuCNPs in HeLa cells (a cervical adenocarcinoma) was investigated via an assay based ... platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery...

Ngày tải lên: 21/06/2014, 02:20

... integrated in the model [27] to estimate the amount of drug entering the small intestine as a function of time M = D e−Ke(t) where M is the mass of the drug remaining in the stomach, D is the drug ... ADME to toxicity optimization Burlington: Elseveir; 2008 doi:10.1186/1556-276X-6-413 Cite this article as: Chiang et al.: Investigation of utilization of nanosuspens...

Ngày tải lên: 21/06/2014, 03:20

... antibody (mAb) as a drug targeting system To investigate the possibility for therapeutic intervention in arthritis, antiCD134 liposomes were loaded with a cytostatic drug and administered early in ... diseaseassociated epitope Mt HSP60176–190 Specific targeting to CD134+ T cells in draining lymph nodes with anti-CD134 liposomes For delivery of modulating compounds...

Ngày tải lên: 09/08/2014, 06:22

... the design and evaluation of double- walled microspheres for combined gene therapy and chemotherapy · To produce monodisperse double- walled microspheres loaded with doxorubicin and gene delivery ... scales, and therefore control the drug release from the microspheres, and finally, iii) the doublewalled microspheres could deliver drug and gene simultaneo...

Ngày tải lên: 10/09/2015, 09:05

... cellular models for drug development The choice of the cell type to be used for drug development application depends mainly on factors such as application and cost In vitro cellular models are ... platforms facilitating scalable and robust screening of drugs Listed below are various tissue engineered liver models for various applications: Tissue engineered Models Spe...

Ngày tải lên: 10/09/2015, 09:12