transporters as molecular targets for drug delivery and disposition
Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
... hepatopancreas, in which serine proteases dominate (collagenase, 157 Abstracts elastase and trypsin- and chymotripsin-like proteinases) As proteinases from king red crab hepatopancreas have high ... proteinases A (asparagine protease) and B (serine protease), and low molecular inhibitors of serine proteinases from fruiting bodies of mushrooms Pleurotus ostreatus and Lentinus edodes as well as ... with endoproteinase Asp-N the product was analyzed by SDS-PAGE and activity assay, showing a high reduction of the molecular mass and only a loss of the activity of the 20% CD and 15N-1H-HSQC...
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Controlled release alginate based microparticulate systems for drug delivery and chemoembolization
... sustain drug release for a prolonged period of time and is therefore not suitable where relatively fast drug release is desired On the contrary, drug release from x alginate matrix is relatively fast ... 1995) C3 Drug release mechanisms of controlled release delivery system Drug release mechanisms depend on the properties of the polymeric carrier, drug and additives present The release of drug from ... to modify drug release from alginate matrices (Chan and Heng, 1998) In some studies, drug release was modified by employing polycations, such as chitosan and poly-L-lysine (PLL) to form a polyelectrolyte...
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Báo cáo khoa học: Molecular cloning and characterization of two soybean protein disulfide isomerases as molecular chaperones for seed storage proteins doc
... Biotech, Kyoto, Japan) RNaseA refolding assay PDI activity was assayed by the measurement of RNase activity produced through the regeneration of the active form from reduced RNaseA as described previously ... of reduced and denatured RNaseA, was examined The specific activities of GmPDIL-1 and GmPDIL-2 were 472 and 300 mmol RNaseAÆmin)1Æmol)1, respectively (Fig 2A) Several mammalian and yeast PDI family ... globular protein, and the calculated a-helical content was 34% and 28% for PDIL-1 and PDIL-2, respectively (data not shown) The domain structures of GmPDIL-1 and GmPDIL-2 were predicted to form a linear...
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Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx
... alternate conformations were observed for residues with longer and flexible side chains, such as Lys The number of alternate conformations was in the Comparison of ligand bound and unliganded PR structures ... region (Ile50 and 50¢) and P2 and P1¢ of the inhibitor, which has been proven to be important for catalysis [30,31], and the other mediates the interactions of P2¢ with Gly27¢ and Asp29¢ Complex ... occupancies of 0.6 and 0.4 and 0.8 and 0.2 for PR–p6pol-PR and PRV82A–p6pol-PR complexes, respectively As the p6pol-PR analog had 11 residues and extended out of the PR-binding pocket, both N- and C-terminal...
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Design and fabrication of microneedles for drug delivery
... are designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis ... varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic system and the continuous delivery ... the upper skin layer and pierce the upper epidermis so as to increase skin permeability and, therefore, improve drug delivery efficiency With microholes in the skin, the drug delivery relied mainly...
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Flavor enhancement as a tool for increasing pleasantness and intakeof a snack product among the elderly
... water before tasting the samples and between samples The samples were coded with three-digit random numbers, and their presentation order was individually randomized for each subject Before evaluating ... taste and smell: Drug interactions and food preferences Nutrition Reviews, 52(8), S11–S14 Schiffman, S S (1997) Taste and smell losses in normal aging and disease Journal of American Medical Association, ... results and evidence for and against on that matter Acknowledgements The authors thank practical trainees Linda van Mierlo and Pascalle Weijzen from Wageningen University, The Netherlands, for assistance...
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Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx
... technology as well as for a complete evaluation of the possible consequences of use of hiPSCs for drug screening, as disease models and for medical purposes Conclusions The use of stem cells for the treatment ... groups As early as 1970, Moore and Metcalf [31] demonstrated that primitive hematopoiesis starts with the formation of yolk sac blood islands in mouse embryos, and later studies by Medvinsky and ... hemangioblast in vivo is widely accepted and has been described in Drosophila, zebrafish and mice [41–43], identification of a human hemangioblast in vivo has not yet been achieved, and is hindered...
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Báo cáo khoa học: Polyamines interact with DNA as molecular aggregates Luciano D’Agostino1 and Aldo Di Luccia doc
... C and D show the same DNA preincubated for at 37 °C with 8000 and 4800 and < 1000 NAPs, respectively A faster migration of the DNA in presence of 4800 NAP was shown Electrophoresis was performed ... indicated that gastrin promotes cell replication: before gastrin treatment, 31% of Caco-cells incorporated BrdU, whereas after and h 46% and 50% incorporated BrdU, respectively An increased BrdU incorporation ... increased BrdU incorporation (40%) was recorded as long as and 12 h after gastrin treatment The GPC analysis performed on the nuclear extracts of Caco-2 cells starved for days revealed a very low
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... CD44v6 is expressed in breast, cervical and colon cancers, and in squamous cell carcinomas Thus CD44v was chosen as a model for therapy A Phase clinical trial was performed with an immunotoxin ... fibrosarcomas, breast cancer, mesotheliomas and prostate cancer, transfected with HAS1, HAS2 and HAS3 genes, triggered intracellular signaling pathways that promoted anchorage-independent growth and ... cancer-associated stromal myofibroblasts [103] As hMSCs can be easily expanded in vitro and possess an extensive multipotent capacity for differentiation, they have been explored as vehicles for...
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nanoparticle technology for drug delivery, 2006, p.427
... Edition, Revised and Expanded, Sanford Bolton 45 Biodegradable Polymers as Drug Delivery Systems, edited by Mark Chasin and Robert Langer 46 Preclinical Drug Disposition: A Laboratory Handbook, Francis ... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems: Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... accessing deep molecular targets, and controlling drug release, nanoparticles are helping address challenges to face the delivery of modern, as well as conventional drugs Since the majority of drug products...
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Báo cáo hóa học: "Single-component Polymer Nanocapsules for Drug Delivery Application" docx
... cell death Drug- release studies confirmed that the Dox was gradually released from PGA-Dox capsules under lysosomal conditions (pH 5.8/10 mM carboxypeptidase) with a nearlinear drug release kinetics ... h ‘‘Moreover, for a drug delivery vehicle to be highly effective, it is desirable that it should not degrade in the blood stream; however, it should be easily degraded and release its cargo after ... degradation and Dox-release studies at conditions resembling those within the living cells, nanocapsule uptake by LIM1215 human colorectal tumor cells, and delivery of the anticancer drug into...
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Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
... Garrett and Mundy Figure In vitro effects Simvastatin, mevastatin and atorvastatin (but not pravastatin) were found to have identical effects to those seen with lovastatin Cerivastatin, however, was ... formation and osteoblast accumulation Cultures exposed for days show further enhancement of bone formation It has been shown that statins cause a marked increase in osteoblast accumulation and new ... Fibroblast growth factor has been previously shown to stimulate bone formation in vivo and was used as a positive control The anabolic effect of statins was confirmed with significant increases...
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Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc
... added, and the plate was incubated for hour at room temperature The wells were washed with PBST and the colour was developed with 100 μL of 1:1 mixture of stabilised hydrogen peroxide and stabilised ... Page of 10 (page number not for citation purposes) was necessary for at least two reasons First, there was a need to perform these control tests for the correct evaluation of the action of the complete ... containing DXM and SPIONs presented an efficacy as good as DXM suspension, proving, on one hand, that the active substance is released from the microparticles and reaches the corticoid receptors and, on...
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báo cáo khoa học: "Computerized clinical decision support systems for drug prescribing and management: A decision-maker-researcher partnership systematic review" pot
... Reminders for prescribing of antibiotics and drugs for asthma, COPD, and dyslipidaemia 23*/53/3,496 Sum scores for appropriate prescribing of antibiotics, statins, cholesterollowering drugs or drugs for ... guidelines for use of aspirin, oestrogen or calcium, ACEIs, heparin prophylaxis, and b-blockers Alerts for drug allergies 6*/276/5,219 and drug- drug interactions, and options for cost-effective ... predominantly about drug therapy was classified as drug therapy management only (Rxonly) Systems that gave advice on drug therapy as part of a more complex intervention were categorised as ‘multi-faceted’...
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báo cáo khoa học: " Assisted injection in outdoor venues: an observational study of risks and implications for service delivery and harm reduction programming" pps
... involvement was associated with reporting assisted injection outdoors, and this association was independent from the association of female sex When drugs are shared among sex workers and their clients, ... inform the activities of the IST, a communitybased research partnership was developed between VANDU and the British Columbia Centre for Excellence in HIV/AIDS As part of this collaborative effort, ... injecting, as well as the stipulations of the exemption granted to the SIF [7] and stems from the potential for criminal and civil liability from assisted injection [8] Therefore, IDU who require assistance...
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Báo cáo y học: "A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors Steffen Eikenberry" ppsx
... types and individual tumors Surface areas were measured as 1.2–2.6 × 104[31], 1.5–5.7 × 104, and 0.5–2.0 × 104 mm2/g wet wt [21] for mouse mammary carcinomas, mouse mammary adenocarcinomas, and ... the plasma distribution (α) phase, and in this phase a gradient of both intracellular and extracellular drug is established In the second phase, corresponding to the plasma elimination (γ) phase, ... DOX delivery to the tumor cord As expected, increasing the fraction of plasma drug that is free significantly improves delivery and cell kill Unexpectedly, however, this is not the case for free...
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Báo cáo y học: "The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information" potx
... source for the names and symbols associated with mouse genes, alleles and strains The advantage of applying such nomenclatures has been increasingly recognized as genomes become better defined and ... approximately 100 terms, such as heart/cardiovascular dysmorphology and skeletal axial defects As we used this list for annotations, terms were refined and general organizing principles for the MP vocabulary ... pseudogene, expressed sequence tag (EST), and so forth deposited research A further detriment to database text records is their difficulty to update and maintain As new information is learned about a phenotypic...
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Báo cáo sinh học: " HCV entry receptors as potential targets for siRNA-based inhibition of HCV" ppt
... day, the adherent cells were washed three times with 1X PBS, complete medium was added and incubation was continued for 48 hrs Cells were harvested and assessed for the presence of viral RNA ... scrambled siRNAs (Sc) or siRNAs of CD-81, LDL, SR and CLD and incubated for hrs before adding HCV-3a sera (Ser 3a) HCV RNA levels were quantified by real-time PCR Data are expressed as mean percent ... analysis and literature review and arranges data HS was principle investigator of the study All authors read and approved the final manuscript Authors’ information Jahan S and Khaliq S (PhD Molecular...
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broadband as a platform for economic, social and cultural development - lessons from asia - bb as a platform, oecd, 19 nov
... broadband is increasingly substituting for telephone service Of course, it is not possible to forecast whether these trends will persist over a long period, as was the case for instance for Moore’s ... greater with broadband;4 Broadband is credited with boosting e-commerce sales, for instance for sales of movies both for online delivery and for online ordering;5 Mobile broadband can improve business ... America and Western Europe, where broadband’s impact was delayed compared with Asia, and the evidence relates to the early years of the 2000s, before the higher speeds and lower prices for broadband...
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Particle development for drug delivery
... whereas for particle classification, an air classifying system (50 ATP, Hosokawa Micron Alpine) was selected for investigation The effects of process variables such as beater rotational speed, classifier ... proposed the Biopharmaceutics Classification Scheme (Table 1), consisting of four classes of drugs For Class I and III drugs, the high solubility will mean that the rate of drug appearance in the blood ... is determined by the absorption rate of the drug whereas for Class II drugs, the rate of dissolution plays a greater role In the case of Class IV drugs, both rates are equally important I Introduction...
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