polymeric nanocapsules for drug delivery an overview

... nanocapsule uptake by LIM1215 human colorectal tumor cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death Bansal notes that it is highly desirable for antitumor ... polypeptide -drug conjugates [PGA-Doxorubicin (Dox)] The researchers also investigated the applicability of thick-walled polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded ... site, thus minimizing any systemic toxicity Moreover, significantly higher amounts and more than one type of drug can be principally loaded in PGA capsules in a controlled manner, due to the presence...

Ngày tải lên: 22/06/2014, 01:20

... DXM and SPIONs (referred to as complete microparticles) as an anti-inflammatory drug delivery system in an experimental model of antigen-induced arthritis (AIA) in mice Figure Materials and methods ... formaldehyde in PBS and used for histological analysis All experimental procedures on animals reported in this paper were performed in compliance with Swiss federal law on the protection of animals ... change with the angle to the magnetisation axis, remaining at around 0.1 T for angles between 0° and 90° In contrast, the flux density rapidly changed with the distance between the magnet and...

Ngày tải lên: 09/08/2014, 14:20

... S Banker and Christopher T Rhodes 122 Surfactants and Polymers in Drug Delivery, Martin Malmsten 123 Transdermal Drug Delivery: Second Edition, Revised and Expanded, edited by Richard H Guy and ... injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, Chapter 11 for ocular delivery, and Chapter 12 for gene delivery Finally, the fourth section provides an overview ... Specialized Drug Delivery Systems: Manufacturing and Production Technology, edited by Praveen Tyle 42 Topical Drug Delivery Formulations, edited by David W Osborne and Anton H Amann 43 Drug Stability:...

Ngày tải lên: 04/06/2014, 15:15

... (APIs) For example, alginate microspheres had been developed as a drug delivery system (DDS) for many peptide and protein drugs (Chan and Heng, 1998) An ideal DDS is able to control the drug concentration ... C3 Drug release mechanisms of controlled release delivery system Drug release mechanisms depend on the properties of the polymeric carrier, drug and additives present The release of drug from polymeric ... the drug is leached out gradually With careful design and fabrication, drug concentration can be maintained within the therapeutic range for weeks, months, and even several years (Banker and...

Ngày tải lên: 13/09/2015, 20:39

... deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis and anti-tumor therapies In transdermal ... Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which have sophisticated compounds ... permeability and energy of drug molecules to enhance the transdermal transport [35] In addition, magnetophoresis has also been applied in transdermal drug delivery using magnetic energy to increase drug...

Ngày tải lên: 14/09/2015, 11:17

... for providing the postgraduate research scholarship My thanks go to Teresa, Mei Yin, Celine, Tin Wui and Charlene for their technical assistance, and to Professor Lucy Wan and Dr Anthony Yolande, ... classes of drugs For Class I and III drugs, the high solubility will mean that the rate of drug appearance in the blood is determined by the absorption rate of the drug whereas for Class II drugs, ... GI wall and / or liver and many others (Dressman, 2000) Assuming that the effects of these factors are negligible, two dominant rate-limiting steps can determine the rate of drug appearance in...

Ngày tải lên: 17/09/2015, 17:19

... used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents an interesting solution for building an ... Nanotransducer for In Vivo gene thErapy, STRP 033378) project, co-financed by the 6FP of the European Commission, and by the IIT (Italian Institute of Technology) Network Authors gratefully thank ... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation,...

Ngày tải lên: 22/06/2014, 00:20

... Development a carrier system for hydrophobic drug delivery for enhanced delivery of anticancer drugs to cancer cells, prolonged the circulation and sustained release Self-assembled polymeric micelles based ... representation of the delivery mechanism of small-molecule drugs to tumors [31] 13 Figure 2.3 Schematic of organic and inorganic drug delivery systems for cancer diagnosis and therapy [39] ... cancer diagnosis and therapy [39] The existing challenges of drug delivery system are to design suitable carriers that can efficiently encapsulate anticancer drugs, overcome drug- resistance, and...

Ngày tải lên: 10/09/2015, 09:06

... mixed micelles formulation showed enhanced drug accumulation in drug resistant tumors Based on these results, the mixed micelles may be an appropriate formulation for drug resistant tumors overexpressed ... cyclosporine A and verapamil 10, 11 However, cyclosporine A and verapamil are immunosuppressant drugs and can cause side effects when they are used as MDR-reversing agents with anticancer drugs Therefore, ... Scheme of the antibody -drug and antibody-polymer -drug conjugates 23 The most important groups in the antibody molecule employed for conjugation with drugs are carboxylic (of aspartic and glutamic...

Ngày tải lên: 12/09/2015, 08:20

... efficacy and thus repeated doses of anticancer drugs are needed With these problems in hand, there is a pressing need to develop drug delivery carriers for effective transportation of anticancer drugs ... K Tan, C Yang, J L Hedrick and Y Y Yang, Delivery of Anticancer Drugs Using Functionalized Polycarbonates Stabilized by Hydrogen bonding,” 6th International Conference on Materials for Advanced ... Ebrahim Attia, J P K Tan, C Yang, J L Hedrick, Y Y Yang, “Acidand Urea-Functionalized Polycarbonate Micellar Nanoparticles Stabilized by Hydrogen bonding for Anticancer Drug Delivery, ” Materials...

Ngày tải lên: 30/09/2015, 06:07

... Kingdom Romania Slovak Republic Romania Slovak Republic Poland Portugal Poland Portugal Malta Netherlands Luxembourg Latvia Lithuania Italy Ireland Greece Hungary France Germany Estonia Finland Denmark ... less than 10MWh, (b) 3.69€c/kWh for consumption between 10MWh and 50MWh, (c) 1.02€c/kWh for consumption between 50MWh and 10GWh and (d) 0.10€c/kWh for private consumers and 0.05€c/kWh for commercial ... Spain Slovenia Romania United Kingdom EU Member State Slovak Republic Poland Portugal Malta Netherlands Lithuania Luxembourg Italy Latvia Ireland Hungary Greece Germany France Finland Estonia Denmark...

Ngày tải lên: 05/09/2013, 16:10

... user interface and more talking about management, deployment, and security This book is just an introduction an overview For more detailed information about any of the features and capabilities ... smooth and intuitive Users have instant access to the information they care about most, like their contacts, apps, and other information They can spend less time looking for information and more ... time Task Manager With the new Task Manager, you can quickly see running programs and can also end tasks if there is an issue But IT pros and power users frequently want to see more information...

Ngày tải lên: 18/02/2014, 06:20

... user interface and more talking about management, deployment, and security This book is just an ­ntroduction, an overview For more detailed information about any of the i f ­ eatures and capabilities ... smooth and intuitive Users have instant access to the information they care about most, like their contacts, apps, and other information They can spend less time looking for information and more ... time Task Manager With the new Task Manager, you can quickly see running programs and can also end tasks if there is an issue But IT pros and power users frequently want to see more information...

Ngày tải lên: 05/03/2014, 20:20

... cancers Nasal/nasopharyngeal cancer Bone cancer Breast cancer Female reproductive cancers (cervical, uterine, ovarian) Urinary bladder cancer Renal cancer Testicular cancer Leukemia (other than ... exposure, and brain cancer.12 Other Cancers Available evidence does not permit a conclusion regarding an association between Agent Orange exposure and other cancers, including cancers of the nose and ... is little precise information for any individual veteran, about how much exposure he or she sustained, or even to what herbicides ASSOCIATION OF AGENT ORANGE AND CANCER Human Evidence Epidemiologic...

Ngày tải lên: 15/03/2014, 01:20

... user interface and more talking about management, deployment, and security This book is just an ­ntroduction, an overview For more detailed information about any of the i f ­ eatures and capabilities ... smooth and intuitive Users have instant access to the information they care about most, like their contacts, apps, and other information They can spend less time looking for information and more ... time Task Manager With the new Task Manager, you can quickly see running programs and can also end tasks if there is an issue But IT pros and power users frequently want to see more information...

Ngày tải lên: 15/03/2014, 09:42

Ngày tải lên: 24/03/2014, 01:21

... against oncogenic HPV by an HPV-16/18 AS04-adjuvanted cervical cancer vaccine: Importance of virological and clinical endpoints and implications for mass vaccination in cervical cancer prevention Gynecol ... as: Mariani and Venuti: HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future Journal of Translational Medicine 2010 8:105 Submit your next manuscript ... vascular and lymphatic channels and to lymph nodes where immune responses are initiated; most DNA viruses have mechanisms for inhibiting interferon synthesis and receptor signaling, and papillomaviruses...

Ngày tải lên: 18/06/2014, 16:20

... been used for delivery of Schwann cells as well SC/fibrin clot has been inserted in PAN/PVC guidance channels and were used to bridge a transected rat spinal cords This was combined by transduction ... 69:925-933 Iwanami A, Kaneko S, Nakamura M, Kanemura Y, Mori H, Kobayashi S, Yamasaki M, Momoshima S, Ishii H, Ando K, Tanioka Y, Tamaoki N, Nomura T, Toyama Y, Okano H: Transplantation of human neural ... the transected dorsal funiculus bridge the lesion and form myelin J Neurosci 2004, 24:8485-8493 Imaizumi T, Lankford KL, Kocsis JD: Transplantation of olfactory ensheathing cells or Schwann cells...

Ngày tải lên: 19/06/2014, 10:20

... current instance, Padapted,n denotes the adapted probability estimation for instance n, Padapted,n-1 stands for the current instantaneous estimation and parameters whist and winstant reflect ... Learning mechanisms also provide the ground for enabling proactive handling of problematic situations, i.e identifying and handling issues that could undermine the performance of the system before these ... An Overview of Learning Mechanisms for Cognitive Systems Aimilia Bantouna*1, Vera Stavroulaki1, Yiouli Kritikou1, Kostas Tsagkaris1, Panagiotis Demestichas1 and Klaus Moessner2...

Ngày tải lên: 20/06/2014, 20:20

... as Raman and photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, ... system Drug delivery targeted to tumor To deliver anticancer drugs into cancer focus is the prerequisite for the drugs to develop their effects However, some drugs cannot arrive or enter cancer ... of carbon nanotubes and bundles of carbon nanotubes Carbon 2001, 4:507-514 Yang Z, Zhang Y, Yang Y, Sun L, Han D, Hong Li, Wang C: Pharmacological and toxicological target organelles and safe use...

Ngày tải lên: 20/06/2014, 22:20