large porous carriers of nanoparticles for drug delivery

... Chapter Review of Microfabricated Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which ... the implementation of time varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic ... be used for local delivery of other drugs, for example, drugs in anti-restenosis and anti-tumor therapies In transdermal drug delivery, microneedles are designed to painlessly deliver drugs into...

Ngày tải lên: 14/09/2015, 11:17

... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation, ... can form extended neural network upon differentiation [5] In this study, we propose a combination of drug delivery system with such CNT array, exploiting a thin film of calcium alginate as drug ... to form microbundles, driven by the capillary force of water droplets In order to prevent the CNT sticking in a liquid environment, and to improve mechanical features of CNTs, a thin layer of...

Ngày tải lên: 22/06/2014, 00:20

... control of the rate of polymer degradation can be achieved thereby changing rate of release of the drug Our study focuses on developing controlled releases implants in the form of discs for Paclitaxel ... account for a larger portion of the drug) would serves as a depot for future continuous paclitaxel release Over the duration of the experimental groups, no sign of weight loss or indication of toxicity ... some form of transporter (e.g nanoparticles) maybe needed to carry the free form of the drug deeper into the tissue before releasing it Page 25 Ong Yung Sheng, Benjamin CHAPTER 4: EVALUATION OF...

Ngày tải lên: 05/10/2015, 21:33

... EVALUATION OF TRANSFERRIN-CONJUGATED LIPID SHELL AND POLYMER CORE NANOPARTICLES FOR TARGETED DELIVERY OF DOCETAXEL PHYO WAI MIN (M.B.,B.S (YGN) U.M(1)) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ... synthesize nanoparticles to encapsulate a variety of therapeutic compounds (Feng, 2006) PEGylation, which refers to polyethylene glycol conjugated drugs or drug carriers, is essential for drug delivery ... and formulations of drug delivery system is provided The strategies applied for targeted drug delivery system is also clearly described in this chapter Then, the synthesis and characterization of...

Ngày tải lên: 09/10/2015, 11:18

... paraphrases for a large set of surface patterns using distributional similarity over a large corpus and then obtains patterns for a relation by simply finding paraphrases (of ine) for a few seed ... pl } be the set of all phrases of the form X pi Y where pi ∈ P Let Si,X be the set of words that occur in position X of pi and Si,Y be the set of words that occur in position Y of pi Let Vi be ... accuracy for them) This is not unexpected, as the larger resource would have a much larger recall, which again points at the advantage of using a large data set Another reason for this performance...

Ngày tải lên: 23/03/2014, 17:20

... injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, Chapter 11 for ocular delivery, and Chapter 12 for gene delivery Finally, the fourth section provides an overview of the ... applications of nanoparticles in drug delivery Depending on the route and purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable ... size of nanoparticles in perspective, Table compares sizes of various objects Because of the comparable size of the components in the human cells, nanoparticles are of great interest in drug delivery...

Ngày tải lên: 04/06/2014, 15:15

... polypeptide -drug conjugates [PGA-Doxorubicin (Dox)] The researchers also investigated the applicability of thick-walled polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded ... cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death Bansal notes that it is highly desirable for antitumor applications, that the size of the delivery vehicle ... one type of drug can be principally loaded in PGA capsules in a controlled manner, due to the presence of a large number of free –COOH groups In addition, the remaining free –COOH groups of PGA-Dox...

Ngày tải lên: 22/06/2014, 01:20

... This extended number of conditions, which led us to the use of a rather limited number of animals per group, Page of 10 (page number not for citation purposes) was necessary for at least two reasons ... anti-inflammatory drug delivery system in an experimental model of antigen-induced arthritis (AIA) in mice Figure Materials and methods Microparticle preparation The microparticles of a mean of and 10 ... arthritis, the articular retention of magnetic microparticles of a mean of and 10 μm in diameter with and without a magnet was compared by means of in vivo imaging For this long-term study, we used...

Ngày tải lên: 09/08/2014, 14:20

... characteristics of the final product The successful formulation of a stable and effective dosage form therefore depends on the careful selection of excipients The use of polymers in the formulation of controlled ... employed to solve the problem of rapid drug release A key consideration in the modification of drug delivery systems is the controlled release of drug at the site of action For example, additives such ... INTRODUCTION delivery of drug In time-controlled delivery, the drug is released in a pre-determined rate while in target-controlled delivery, the drug is delivered to a specific site The delivery...

Ngày tải lên: 13/09/2015, 20:39

... the rate of drug appearance in the blood is determined by the absorption rate of the drug whereas for Class II drugs, the rate of dissolution plays a greater role In the case of Class IV drugs, ... procedure for the 162 analysis of the effects of varying rotational speeds of the classifier wheel Table 21 Results of the Dunn Multiple-Comparisons procedure for the 168 analysis of the effects of ... PARTICLE DEVELOPMENT FOR DRUG DELIVERY LEE CHIN CHIAT B Sc (Pharm) (Hons) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF PHARMACY NATIONAL UNIVERSITY OF SINGAPORE 2004 To...

Ngày tải lên: 17/09/2015, 17:19

... http://www.nanoscalereslett.com/content/6/1/445 capable of inducing oxidative stress, which is of great concern in terms of the nanotoxicology of particles being pursued for a variety of consumer products Furthermore, ... of 10 B C Figure Characterization of CuCNPs (A) SEM image of CuCNPs, (B) EDX spectra of CNPs before (left) and after (right) addition of Cu, (C) XPS spectra for CuCNPs (right) and control particles ... molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when applied to targeted drug delivery One of the goals of this work was to demonstrate...

Ngày tải lên: 21/06/2014, 02:20

... biosafety of SWCNT used as drug carriers Although there are exciting prospects for the application of CNTs as drug carriers in medicine, one of the key obstacles in the way for the use of SWCNT as drug ... schematic illustration of the strategy for the preparation of the CNT-based drug delivery systems Figure The modification of CNTs Schematic illustration of modification of CNTs with various molecules ... great possibilities for them to be used in the construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems will...

Ngày tải lên: 20/06/2014, 22:20

... Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery Nanoscale ... of the drug In order to overcome these limitations, a suitable formulation was needed to maximize the potential of DCU in vivo Several formulations strategies for SC dose have been assessed Formulations ... new drug entities in early drug discovery: the potential impact of formulation on pharmacokinetic parameters Curr Op Drug Discov Devel 2002, 5(1):59-71 17 Barrett R: Nanosuspensions in drug delivery...

Ngày tải lên: 21/06/2014, 03:20

... characteristic peak of 5.2 and 1.69 ppm for PLA, 4.82 ppm for PGA and at that of 3.65 ppm for TPGS, respectively Characterization of Drug- Loaded Nanoparticles Size, Zeta Potential and Drug Entrapment ... The morphology of the nanoparticles formed was recorded as smooth and spherical in shape In vitro Drug Release The in vitro drug release profiles of the 5% DMAB-modified PLGA nanoparticles (ANP),unmodified ... effects of TPGS and DMAB component of the nanoparticles in enhancing cellular uptake of the nanoparticles (2) The advantages in cancer cell viability of the 5% DMABmodified PLGA-TPGS nanoparticles...

Ngày tải lên: 21/06/2014, 08:20

... carrier for gene, and/or drug delivery For instance, Lin and Wang utilized the MSNs with honeycomb structure for delivering DNA and chemicals into plants [17] In the case of the MSNs system, the drugs ... basic solution Therefore, NH4OH as a base catalyst for the hydrolysis and condensation reactions could trap the dissolved bFGF in the negative charge of nanoparticles with the form of Si–O- on the ... stay outside of the nuclei of the cells The morphology of HUVEC cells did not vary after internalization of MSNs, indicating that the MSNs are not only a biocompatible delivery system for growth...

Ngày tải lên: 22/06/2014, 00:20

... certainly made a large difference for occasion of drug delivery to the fungus cell Having a loose or a more tightly packed assembly originated considerable differences in the profile of cell viability ... hydrophobic sites of DODAB BF to be occupied by the monomeric drug In absence of CMC, DODAB BF might fuse diminishing drug solubilization at their rim Page of 13 (page number not for citation purposes) ... edges of cationic bilayer fragments state of theBAdsorption of carboxy methylcellulose onto amphotericin B- cationic lipid assemblies preserves monomeric state of the drug at the edges of cationic...

Ngày tải lên: 11/08/2014, 00:22

... process(es) Over the past couple of decades, the field of drug delivery has been revolutionized with the advent of nanoparticles, wherein these particles act as inert carriers for drugs and genes to target ... excreted [11] Therefore, PLGA nanoparticles, due to their ability to entrap both watersoluble and water-insoluble molecules, are in process of extensive evaluation for the delivery of drugs, genetic ... half-life of the nile red (Fig 4) Bladder shows the significant amounts of excreted nanoparticles Page of 18 demonstrating the efficient clearance of biodegradable nanoparticles overtime PLGA-PEG nanoparticles...

Ngày tải lên: 11/08/2014, 00:22

... Institute for BioNanotechnology in Medicine Requirements for Drug Delivery • Drug delivery particle should self-assemble from drug molecules, components for targeting, and components for stability ... Components of drug delivery system should easily be removed from the organism Institute for BioNanotechnology in Medicine Polymeric Nanoparticles as Model Drug Delivery Vehicles Institute for BioNanotechnology ... penetration in target tissue and cells (< 400 nm for tumor tissue) • Drug delivery particles should be stable and biologically inert before reaching their target • Drug release should result from interactions...

Ngày tải lên: 23/08/2015, 18:48

... and 5-fold axes of symmetry (c) Introduction of pentamers induces curvature in a planar sheet of hexamers that allow for the formation of an icosahedron (d) Calculation of T value for the icosahedral ... al., 1997; Lu and Low, 2002] Proof of concept of the folic acid-mediated targeting systems has been obtained with the delivery of drugs and liposomes to a variety of cancer cells [Leamon and Low, ... model drug in the development of targeting drug delivery platforms [Kalra and Campbell, 2006; Sun et al., 2006; Nasongkla et al., 2006] Figure 1-1 Chemical structure of doxorubicin 1.2 Targeted drug...

Ngày tải lên: 11/09/2015, 14:22

... be used for specific delivery of anticancer agents, tracking of therapeutic delivery, and detection of treatment effects in real time 1.3.1 Integration of imaging and therapy Fluorescent nanoparticles ... nanoparticles Furthermore, several kinds of targeted delivery system were developed for tumor labeling applications in vivo Liposomes, the most clinically established nanoparticles for drug delivery ... injection To examine the drug delivery of the NPs, the cytotoxic effect of DOX-loaded NPs was tested on SK-BR-3 cells, indicating that mesoporous silica NPs has a potential for drug delivery into cancer...

Ngày tải lên: 14/09/2015, 08:39