Regulation of subcellular localization and functions of RGK proteins by 14 3 3 and calmodulin

... relocalization of RGK proteins by 14- 3- 3 3- 3A Regulation of localization of Kir/Gem by 14- 3- 3 3- 3B Regulation of localization of Rad by 14- 3- 3 3- 3C Regulation of localization of Rem1 by 14- 3- 3 ... Regulation of localization of Rem1 L271G and mutants by 14- 3- 3 3- 5E Regulation of localization of Rem2 L317G and mutants by 14- 3- 3 3- 5F Binding of 14- 3- 3 to RGK mutants lacking CaM binding 3- 6 Quantification ... Regulation of localization of Kir/Gem W269G and mutants by 14- 3- 3 3- 5B Binding of 14- 3- 3 to Kir/Gem mutants lacking CaM binding 3- 5C Regulation of localization of Rad L281G and mutants by 14- 3- 3 3- 5D Regulation...

Báo cáo y học: " Increased production of viral proteins by a 3''''-LTR-deleted infectious clone of human T-cell leukemia virus type 1" ppsx

... Niinuma A, Ohashi M, Fukushi M, Oie M, Akiyama T, Tanaka Y, Gejyo F, Fujii M: PDZ domain-binding motif of human T-cell leukemia virus type Tax oncoprotein augments the transforming activity in a rat ... Yoshida S, Oie M, Tanaka Y, Takahashi S, Xie L, Green PL, Fujii M: Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type Tax ... Sun SC, Yamaoka S: Activation of NF-kappaB by HTLV-I and implications for cell transformation Oncogene 2005, 24:5952-5964 Winter HY, Marriott SJ: Human T-cell leukemia virus type Tax enhances serum...

Báo cáo khoa học: Identiﬁcation, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt

... natural transformation of T thermophilus HB27 Furthermore, we present the ﬁrst information on the subcellular localization of the PilMNOWQ and PilA4 competence proteins and on the effect of mutations ... in pilQ led to the absence of PilW and PilA4 in the inner membrane In addition, pilW mutation resulted in the absence of PilQ and PilA4 in the outer membrane The abilities of PilW, PilQ and PilA4 ... observed binding of gold-labeled antibodies to the pilus (data not shown) This ﬁnding suggests that either PilA4 is not part of the pilus, PilA4 is inaccessible in the native pilus, or the PilA4...

Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx

... IRF -3 responsive, including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-speciﬁc counterpart [16] The two isoforms ... ArgII expression was inhibited by MG- 132 [20], suggesting indirectly an involvement of NF-jB in ArgII regulation Our study is thus the ﬁrst direct demonstration of the involvement of IRF -3 in ... spermidine and spermine) through conversion of l-arginine into l-ornithine [16] The latter is in turn used by ODC to produce putrescine, the precursor of spermidine and spermine To further analyze the...

Báo cáo khoa học: Regulation of phospholipid biosynthesis by phosphatidylinositol transfer protein Sec14p and its homologues pot

... shared by Sec14p and Sfh proteins assumes functional signiﬁcance because some of the Sec14 homologues (namely Sfh2 and Sfh4), when overexpressed, complemented the sec14-related growth and secretory ... could substitute for Sec14p in its role as a regulator of phospholipid biosynthesis Under conditions where Sec14p is nonfunctional and the CDP-choline pathway for PtdCho biosynthesis is blocked, ... Characteristics of the enzyme and identiﬁcation of its structural gene in yeast J Biol Chem 256, 7077–7085 Greenberg, M.L & Lopes, J.M (1996) Genetic regulation of phospholipid biosynthesis in...

Báo cáo khoa học: Regulation of STAT signalling by proteolytic processing Lisa Hendry and Susan John doc

... suggest that proteolytic processing is a general mechanism for the negative regulation of STAT protein function (Fig 4) Truncated forms of Stat3 , Stat5 a, Stat5 b and Stat6 , generated by the proteolytic ... cells Proteolytic regulation of Stat5 and Stat3 in mature human neutrophils Stat3 and Stat5 isoforms have been identiﬁed in differentiated human peripheral blood monocytes and polymor- Proteolytic ... characterization and puriﬁcation of the protease(s) and the identiﬁcation of the exact cleavage site on Stat5 will be important in enhancing our understanding of the regulation of Stat5 function by proteolytic...

Báo cáo sinh học: " Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR" doc

... recruitment to the FeLV-945 LTR might interfere with CBP availability and thereby alter the regulation of CBP- responsive genes Such alteration might then contribute to altered hematopoiesis and consequent ... regulated by CBP in a manner dependent on the presence of the 21-bp triplication (Figure 7) These results indicated that the interaction between c-Myb and CBP is functional, and suggest that the c-Myb- mediated ... c-Myb- mediated recruitment of CBP to the FeLV-945 LTR could be responsible for the previously reported replicative advantage conferred by the 21-bp triplication [8] CBP and c-Myb are thought to activate...

báo cáo hóa học:" Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR" doc

Báo cáo y học: " Regulation of Sox9 activity by crosstalk with nuclear factor-κB and retinoic acid receptors" pptx

... is likely that the caMEKK1-induced increases in NF-κB and RAR activity are mediated by hyperactivation of p300 Effect of caMEKK1 and ectopic p300 on Sox9 activity (a) Chondroactivity cytes were ... effect of TNF-α on Sox9 activity Finally, the sensitivity of Sox9 to atRA was reduced by caMEKK1 expression Thus, the activity state of p300, the common co-factor and MEKK1 target, probably plays ... RAR activity when chondrocytes were treated with both TNF-α and atRA Regulation of transcription factor activity by p300 Differences in the affinity for p300 may contribute to the pattern of regulation...

REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK ERK IN CELL DYNAMICS

... multi-domain protein, consisting of N-terminal SAM domain, C-terminal START domain and the catalytic RhoGAP domain This allows for its interaction with diverse cellular proteins, including FAK, Tensins ... light chain phosphatase (MLCP) to inactivate it and hence ensuring phosphorylation of myosin by myosin light chain kinase (MLCK) This leads to actin-myosin cross-linking, triggering cell contraction ... 14-3-3 adaptor proteins This interaction, stimulated by protein kinase C and protein kinase D, inhibits the nucleocytoplasmic shuttling of DLC1 and its cellular functions by blocking its nuclear...

Regulation of NMDA receptors by serine proteases tissue plasminogen activator (tPA) and plasminogen plasmin

... treatment of ischemic stroke, a pathophysiological condition in which NMDA receptors are implicated 1.7 Tissue- type Plasminogen Activator (tPA) 1.7.1 tPA and stroke Tissue- type plasminogen activator (tPA) ... Thrombin 1.6.3.4 Tissue- type plasminogen activator (tPA) 22 23 23 24 25 26 27 27 27 29 30 30 30 32 1.7 Tissue- type Plasminogen Activator (tPA) 1.7.1 tPA and stroke 1.7.2 tPA /plasminogen system ... of plasminogen to plasmin is inhibited by tPA’s native inhibitor, plasminogen activator inhibitor (PAI)-1 Similarly, 2-antiplasmin, the native inhibitor of plasmin, can inhibit the activity of...

Regulation of spindle behaviour by DNA replication and damage checkpoints in budding yeast

... Phase and G2/M Checkpoints: In the budding yeast, DNA damage surveillance mechanisms operate in G1, S and G2 phases These are the G1 DNA damage checkpoint, the S phase replication and DNA damage checkpoints, ... REGULATION OF SPINDLE BEHAVIOR BY DNA REPLICATION AND DAMAGE CHECKPOINTS IN BUDDING YEAST SAURABH RAJENDRA NIRANTAR (B.Tech.(Hons), Indian Institute of Technology, Kharagpur) ... Segregation of Damaged Chromosomes in DNA- damaged Cells 122 4.3 Negative Regulation of Microtubule Associated Proteins Cin8 and Kip1 by DNA Damage Checkpoint 130 iv 4.4 Role of Cdh1 in Regulation...

Báo cáo khoa học: Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide pot

... integrated iron moiety and that NO+ from SNP is responsible for its effect on ferritin synthesis Moreover, acute regulation of ferritin synthesis by NO+ is accomplished by a rapid mobilization of polysome-free ... Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, ... immunoprecipitated (by using anti -ferritin IgG) and analyzed by SDS ⁄ PAGE followed by autoradiography iron which could be responsible for the SNP-mediated induction of ferritin synthesis To so,...

REGULATION OF INTEREST RATE BY THE STATE BANK OF VIETNAM (SBV) potx

... of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) FOREWORD We would like to present to you our study on the Regulation of Interest Rate by the State Bank ... many bankers at the conference have given voice to the regulation on Page of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) interest rate- ceiling The State ... national monetary policy The point 12, Article of the Law on the State Bank of Vietnam stipulates: " The basic interest rate is the interest rate announced by the State Bank of Vietnam making a ground...

Báo cáo Y học: Differential regulation of telomerase activity by six telomerase subunits potx

... role of each telomerase subunit in enzyme activity, we used downregulation of telomerase by inducing differentiation of HL-60 cells, and up -regulation of telomerase by stimulating proliferation of ... inhibition of TEP1 function by high concentrations of antisense oligonucleotides, telomerase activity was dramatically diminished Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, ... cells and telomerase activity was measured by TRAP/EIA cells days later (C) Telomerase activity after introduction of antisense oligonucleotides into PHAstimulated lymphocytes Ficoll-Hypaque isolated...

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