The regulation of TXNIP gene expression

... Molecules for Regulating Txnip Expression   3.2.1.13.1 The Induction of Txnip Expression Requires  Intracellular Ca2+    3.2.1.13.2 The Induction of Txnip Expression Does Not  Require cAMP    3.2.1.13.3 The Involvement of MAPK in the Induction of ... 4.2.1.5 ChoREs Are Not Sufficient for the Induction of Txnip Expression   4.2.1.6 Tandem NF‐Y Binding Sites Are Required for the Induction  of...

Ngày tải lên: 14/09/2015, 14:09

... Charan annangudi who was born right after my thesis defense v ABSTRACT Rajarajeswari Muthukrishnan IDENTIFICATION OF A MINIMAL CIS-ELEMENT AND COGNATE TRANSFACTORS REQUIRED FOR THE REGULATION OF ... RAC2 GENE EXPRESSION DURING K562 CELL DIFFERENTIATION This dissertation examines the molecular mechanisms regulating Rac2 gene expression during ce...

Ngày tải lên: 24/08/2014, 12:22

... inhibition of 23 24 25 intervertebral disc degeneration Int J Exp Pathol 2006, 87:17-28 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral disc ... cells by the action of TNF-α Discussion This study investigates the effect of the pro-inflammatory cytokines IL-1β and TNF-α on catabolic gene expre...

Ngày tải lên: 09/08/2014, 14:20

... across the BBB to the sites of axonal injury in the brain [33,37] Both in vitro and in vivo findings suggest that hypoxia/ischemia-induced infiltration of monocytes and macrophages contributes to the ... of inflammatory cytokines and chemokines during hypoxia; whereas NFκB is mainly involved in transcriptional regulation of these genes during the phase o...

Ngày tải lên: 19/06/2014, 22:20

... differentially regulated by the two treatment conditions: rhOP-1 down-regulated LIF expression by more than 15-fold, IL-11 expression by more than eight-fold, IL-8 gene by four-fold and IL-6 by two-fold, ... Pathway analysis and classification by gene ontology Regulated genes (R > 1.5-fold, P < 0.001) were used as input for both analyses The ingenuity pathway analysis syst...

Ngày tải lên: 12/08/2014, 15:22

... of the TRIP- Br proteins 17 2.3 The functional properties of the TRIP- Br proteins 18 2.3.1 The unique ability to interact with the PHD zinc 18 finger and/ or the bromodomain iv 2.3.2 The TRIP- Br ... potentials of the TRIP- Br proteins 2.4 The TRIP- Br proteins: a novel class of cell cycle regulator 21 2.4.1 The mammalian cell cycle...

Ngày tải lên: 16/09/2015, 17:12

... 2675 Actin and ABPs in transcription regulation B Zheng et al Table Role of nuclear actin- binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain ... STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates actin- binding in several proteins,...

Ngày tải lên: 07/03/2014, 01:20

... Zinc finger (BTB/POZ) domain in the N-terminal and the Ankyrin Repeat Domain (ARD) in the middle of the protein Whereas AtNPR1 to AtNPR4 have been implicated in signalling of defense responses, AtNPR5 ... Schematic representation comparing the structure of AtNPR1, VvNPR1.1 and VvNPR1.2, including the positions of the BTB/POZ domain, the ankyrin repeat domain (ARD...

Ngày tải lên: 12/08/2014, 03:20

... of this study was to gain more insight of the consequences of the BF intersubtype recombination phenomenon on the different but functionally related genomic regions LTR and Vpr/Tat, through the ... directly bind to p300 via interaction the C-terminal αhelix of the protein [29] suggesting that Vpr may act by recruiting them to the HIV-1 promoter thus enhancing v...

Ngày tải lên: 12/08/2014, 04:21

... of this study was to gain more insight of the consequences of the BF intersubtype recombination phenomenon on the different but functionally related genomic regions LTR and Vpr/Tat, through the ... directly bind to p300 via interaction the C-terminal αhelix of the protein [29] suggesting that Vpr may act by recruiting them to the HIV-1 promoter thus enhancing v...

Ngày tải lên: 12/08/2014, 04:22

... targeted by miRNA (y- axis) as the percentage of disorder increases in the proteome The datasets for the transcripts encoding the disordered proteins (burgundy) and ordered proteins (mauve) and the proteome ... highly disordered proteins with the highly ordered proteins, an increase of 23.5% is observed instead of 42.5%, and comparing the disord...

Ngày tải lên: 14/08/2014, 21:20

... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts...

Ngày tải lên: 16/02/2014, 09:20

... activation was Src- and Shc-dependent and resulted in enhanced expression of the uPA gene and, to a lesser extent, of the MMP-9 gene (data not shown) Disruption of cell–cell adhesion by calcium chelation ... leading to the uPA gene However, the nature of these signaling events has remained largely unknown Because both disruption of E-cadherin- depen...

Ngày tải lên: 19/02/2014, 05:20

... enter the lipid bilayer and contact the quinones dissolved within the bilayer of the cytoplasmic membrane The reduction of NifL by electrons derived from the quinone pool, rather than by a single ... electrons from the reduced quinone pool at the cytoplasmic membrane under depressing conditions In order to verify that in our model...

Ngày tải lên: 17/03/2014, 10:20

... system is the p53- regulated control of the endosomal compartment of the cell (Fig 6) The results presented here begin to outline the way in which the p53 protein regulates the transcription of selected ... of these events (Fig 6) The p53 network also alters several other physiological processes in the cell that are undoubtedly related to the functions of...

Ngày tải lên: 23/03/2014, 04:21