viii— regulation of mucin gene expression in the gallbladder
Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
Ngày tải lên :
09/08/2014, 14:20
... that the lack of TNF-R1 does not affect the incidence or severity of collagen-induced arthritis in the joints [27] Repeated injections of TNF-α into the joints of TNF-R1 knockout mice enhanced the ... among the various age groups studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of ... on expression of interleukin-1 and interleukin-1 receptors The addition of recombinant TNF-α for 48 hours resulted in a significant upregulation of IL-1β and IL-1Ra genes in both normal and degenerate...
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Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx
Ngày tải lên :
14/08/2014, 21:20
... novel insights into the regulation of disordered proteins This aim was achieved and we discuss our findings in the following sections Protein disorder and gene expression On consideration of the gene ... studied The increase in the decay rate of the transcripts encoding disordered proteins is likely attributable, in part, to the increase in predicted miRNA regulation The transcripts encoding disordered ... proteins being targeting for ubiquitination These properties play a role in the high levels of gene expression observed in the highly disordered proteins compared to proteins with less disorder The...
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Báo cáo khoa học: Oxygen control of nif gene expression in Klebsiella pneumoniae depends on NifL reduction at the cytoplasmic membrane by electrons derived from the reduced quinone pool doc
Ngày tải lên :
17/03/2014, 10:20
... streptomycin per ml and subsequent selection of single colonies onto plates resulted in loss of the integrated plasmid with an integration frequency of the interrupted nuoCD region in 50% of the integrants ... regions of NifL-protein are located in the N-terminal domain [31] that binds the FAD-cofactor [17], one can speculate that the N-terminal domain of NifL might enter the lipid bilayer and contact the ... cassette into the EcoRV site of fdnG fragment resulting in pRS177 The 3.2-kb EcoRI/KpnI fragment of pRS177 including the fdnG::tet region was cloned into pKAS46 The construction of the Ó FEBS...
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Báo cáo toán học: "Iodine Alters Gene Expression in the MCF7 Breast Cancer Cell Line: Evidence for an Anti-Estrogen Effect of Iodine" doc
Ngày tải lên :
08/08/2014, 17:20
... of current therapies In this study we provide the first gene array profiling of an estrogen responsive breast cancer cell line demonstrating that the combination of iodine and iodide alters gene ... 2-methoxyestradiol, decreasing 3, 4-estradiol quinone or indirectly via the inactivation of E2 The importance of the CYP1A1/CYP1B1 ratio in- vivo is evident in the increased presence of 4-OH-E2 in breast cancer ... the body of evidence builds, the importance of iodine on the maintenance of healthy breast tissue and its role in carcinogenesis becomes clearer Unveiling iodine’s mechanism of action is of crucial...
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Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats potx
Ngày tải lên :
10/08/2014, 05:21
... hrs after the administration of morning dose of insulin and curcumin The results were expressed in terms of milligram per decilitre of blood Total Dopamine receptor binding studies in the cerebellum ... receptor binding parameters were determined using Scatchard analysis [32] The specific binding was deter- Page of 11 mined by subtracting non-specific binding from the total The binding parameters, ... interest in learning dopamine D2 receptor expression begins with the hypothesis that dopamine D2 receptors are involved in the pathophysiology of schizophrenia and in the mechanism of antipsychotic...
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báo cáo khoa học: " Uncovering the Arabidopsis thaliana nectary transcriptome: investigation of differential gene expression in floral nectariferous tissues" docx
Ngày tải lên :
12/08/2014, 03:20
... Comparison of gene expression in different nectary types Comparison of gene expression in different nectary types The number of genes displaying a two-fold or greater difference in expression in different ... significance of these elements occurring within the promoters of these genes Further information on the MYB4 and CArGCW8GAT promoter motifs are discussed below Discussion Gene expression profiles in different ... 'present' or 'absent' in all biological replicates of the nectary tissues examined (quality setting of 0.04 in Expressionist® Analyst software) The number of genes called 'present' in all replicates...
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Báo cáo y học: "Mouse maps of gene expression in the brain" pot
Ngày tải lên :
14/08/2014, 07:21
... consistent, indicating that the pattern is due to the promoter elements of the gene of interest rather than the genomic insertion point The anatomical annotators of the GENSAT data have embraced the ... protein (EGFP) reporter gene The BAC is then used to create a transgenic mouse line that ideally expresses EGFP in the cells that normally express the gene of interest The advantage of using the ... through the Mutant Mouse Research Resource Centers [8,9] In addition, for some of the most interesting expression patterns, the project is developing lines where the BAC containing the gene promoter...
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Báo cáo y học: "Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system" ppsx
Ngày tải lên :
14/08/2014, 07:22
... number of genes in a given neuron and are, therefore, incomplete To test the applicability of the mRNA-tagging strategy for obtaining a comprehensive gene expression profile of a specific subset of ... 'mountains' based on similarities in gene expression [95] In some instances, co-regulated genes were grouped into specific functional subsets, thereby defining the 'name' of the mountain For ... the majority of genes in this interactome group are expressed in the nervous system favors the idea that these networks reflect authentic interactions in neurons We note that 13 of the proteins...
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Báo cáo y học: "The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever" ppsx
Ngày tải lên :
14/08/2014, 08:20
... determine whether we could detect any changes in gene expression before appearance of symptoms, we examined the gene expression profile of peripheral blood in the early preclinical stages of infection ... subtracting the average of the pre-infection baseline expression level from that animal, so that the values of each time point represent changes relative to the uninfected samples The genes whose expression ... R174 Rubins et al Cy3 signal over the pixels spanning the array element of ≥0.6 and intensity/background ratio of ≥2.5 in at least 80% of the arrays For each gene, the expression levels over the...
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Báo cáo y học: "The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data" pps
Ngày tải lên :
14/08/2014, 08:20
... value of the training samples in the case of continuous variables The aggregate forest's output is then determined by averaging the regression values of the trees or using a weighted voting process ... basis, the random forest determines the importance score of each gene (variable) in the multivariate model The distribution of importance scores of the genes in the category is then compared with the ... activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle J Clin Invest 1994, 94:277-285 Pugh BF: Control of gene expression through regulation of the TATA-binding protein Gene 2000,...
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Báo cáo y học: "The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data" potx
Ngày tải lên :
14/08/2014, 08:20
... SLA2/Huntingtin-interacting protein Hip1 Y66H1B.3 462 784 Actin-binding cytoskeleton protein, filamin Y66H1B.2 119 902 Actin-binding cytoskeleton protein, filamin 766 20 Actin-binding protein Coronin, contains WD40 ... Actin regulatory proteins (gelsolin/villin family) Y71G12B.11 122 Talin W03F11.6 afd-1 - 393 Actin filament-binding protein Afadin F08A8.6 tag-138 - 474 Actin-binding protein SLA2/Huntingtin-interacting ... 24 genes encoding proteosome subunits show elevated expression in the M24 dataset whereas none of these transcripts are enriched in the M0 profile This finding could be indicative of the general...
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IDENTIFICATION OF A MINIMAL CIS-ELEMENT AND COGNATE TRANS-FACTORS REQUIRED FOR THE REGULATION OF RAC2 GENE EXPRESSION DURING K562 CELL DIFFERENTIATION
Ngày tải lên :
24/08/2014, 12:22
... completion of the human genome project, many challenges remain in understanding the regulation of genetic information Human cells contain 20,000-25,000 genes, which include housekeeping genes, genes ... by the presence of one invariant protein motif, the SET domain, which has the potential to methylate lysine in the N-terminal tail of histones There are about ten different SET-domain containing ... compaction of chromatin by binding to the linker DNA Thus a nucleosome without the linker histone H1 resembles beads on a string of DNA The tight interaction of DNA with histone proteins protects them...
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DEVELOPMENTAL DIFFERENCES AND ALTERED GENE EXPRESSION IN THE TS65DN MOUSE MODEL OF DOWN SYNDROME
Ngày tải lên :
24/08/2014, 12:33
... boiling in a microwave and then immediately poured into a glass Coplin jar The Coplin jar was then placed into the 100°C water bath and the slides were then placed in to the Coplin jar for 20 minutes ... examined to determine the total volume of the precursor The area per point was 0.01 mm² and was determined at 4X magnification When measuring brain volume, the area inside the ventricles was included ... study examined gene expression in the brain of P0 Ts1Cje mice and found approximately a 1.5 fold expression level of trisomic genes (AMANO 2004) In the Ts65Dn mouse model, a study of the cerebellum...
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The regulation of TXNIP gene expression
Ngày tải lên :
14/09/2015, 14:09
... 3.2.1.13.2 The Induction of Txnip Expression Does Not Require cAMP 3.2.1.13.3 The Involvement of MAPK in the Induction of Txnip Expression 3.2.1.13.4 Non‐involvement of AMPK in the Induction of Txnip Expression ... 3.2.1.5 Long Term Effect of Adenosine‐containing Molecules on Txnip Expression 3.2.1.6 Adenosine‐containing Molecules Induce Txnip Expression at the Transcriptional Level 3.2.1.7 Adenosine‐containing Molecules Induce Txnip Expression ... the transcription of the Txnip gene is induced by an array of adenosine‐containing molecules, of which an intact adenosine moiety is necessary and sufficient. The induction ...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
Ngày tải lên :
19/02/2014, 05:20
... expression of uPA are causally involved in tumor progression, the understanding of these underlying intracellular events is of importance In the present study, we explored the signaling pathway linking ... leading to endocytosis of the E-cadherin complex Accordingly, in the course of Decma-induced disruption of cell–cell adhesion, Src activation was necessary for the initiation of the signaling ... redistributed into the cytoplasm (Fig 1A, B,D) To determine whether the disruption of cell–cell adhesion by Decma in uenced expression of the uPA gene, we examined change in uPA mRNA levels Northern...
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Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc
Ngày tải lên :
08/03/2014, 16:20
... numbers are indicated above the corresponding exons on the gene structure The sizes of introns and 3, determined using long-PCR, are indicated below the gene structure The length of introns and ... to follow variations of a1,3GalT gene expression in resting and TNFa-stimulated pig endothelial cells The strong homology of exon to a portion of the porcine invariant chain gene did not allow ... another regulatory sequence, as they initiate several hundreds of bp upstream of the start of transcript 5¢-B (Fig 3B) Alternative splicing of the porcine gene is not limited to the 5¢ flanking...
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Report on the Regulation of Reproductive Cell Donation in the European Union potx
Ngày tải lên :
28/03/2014, 16:20
... a lineal kin and a sibling) of the spouse (cohabiting partner) or ae) the spouse (cohabiting partner) of the sibling of the spouse (cohabiting partner) of the recipient and complies with the ... b) the donor offers the cells exclusively for the use of the recipient specified in the declaration of donation; c) the declaration of donation includes – beyond the provisions set forth in Subsection ... Hungary, other than when said contract is in the form of an interstate or intergovernmental agreement or covenant, is the agreement of the Executive Office of the Chief Medical Officer The CMO’s...
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báo cáo hóa học:" Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study" pptx
Ngày tải lên :
20/06/2014, 07:20
... promoter into place, resulting in the inappropriate constitutive expression of the agouti gene [6] In the hypothalamus, the over-expressed agouti protein acts as an antagonist of melanocortin-4 receptors ... consistent with the shift in enzyme expression Discussion This is the first report of differences in the levels of ovarian gene expression in an obese mouse model The most important finding of this study ... overexpression of agouti [9] The similar level of expression of agouti gene in both young and aging LY mice relative to black mice serves as an intrinsic control confirming the comparability of the...
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Báo cáo sinh học: "Conservation of core gene expression in vertebrate tissues" pdf
Ngày tải lên :
06/08/2014, 19:20
... definitions of conservation The expression of these 1,488 genes in modern-day lineages is shown in Figure Most of these genes have tissue-specific patterns of expression, indicating that the genes ... counts in each species TF genes within the set of unique orthologs were defined by the presence of a DNA-binding domain in the mouse protein sequence in the Pfam database [75] Our list of TF genes ... SCEs The expression of these 102 genes in the ten common tissues in the representatives of all modern lineages is shown in Figure Because TF binding sites are degenerate, it is conceivable that these...
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Báo cáo y học: "Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients" pptx
Ngày tải lên :
09/08/2014, 10:20
... ensure the success of ACT in OA joints, the control of articular environment will be of the utmost importance Control of inflammatory stimuli in the affected joint and the removal of any degenerated ... upregulate the production of their own pro-inflammatory cytokines, including IL-1β and tumor necrosis factor-α, under the influence of proinflammatory cytokines present in the synovial tissues of patients ... way of increasing the number of cells available for expansion in order to cover the rather large defects seen in OA However, the additional damage to the joint resulting from the larger number of...
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