viii— regulation of mucin gene expression in the gallbladder

... the prognostic association of SPAG5 in these different subgroups of patients (see Table 4) Table Multiple hypothesis testing of the association of gene SPAG5 with endocrine therapy and chemotherapy ... promoting and regulating several aspects of mitosis, such as inactivating Separase which maintained the cohesion of sister chromatids, stabilizing mitotic spindle, enhancing the fidelity of chromosome ... Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, 42 Baiziting, Nanjing 210009, Jiangsu, China Full list of author information is available at the end of the

Ngày tải lên: 17/06/2020, 18:59

... known to be inefficient in maintaining Treg cells in this model of autoimmunity Expression profiles for these genes, presented in Figure 6b, indicate that the transcript levels of these interactive ... encode for a set of adhesion molecules (Figure 3e) This set of genes consists of a distinct set of collagen genes, the matrilin gene (Matn2), the multiple EGF-like domain gene (Megf9), the procollagen-C ... within either the Aec1 or Aec2 genetic regions Since the vast majority of these 480 genes are scattered throughout the genome, identifying primary candidate genes regulating development of SjS-like

Ngày tải lên: 01/11/2022, 09:56

... patients The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting from mutations in genes preferentially expressed in the neurons of the ... fluorescence * indicates statistically low gene expression compared with the averaged gene expression level of the other parts of the cochlea Table S1 AC C EP ** indicates statistically high gene expression ... Figure Gene expression levels of each cochlear part analyzed by quantitative RT-PCR Expression values of each gene are indicated as the relative value to the Actb expression RI PT level The gene expression

Ngày tải lên: 04/12/2022, 15:00

... Considering that these models can also benefit from increasing the number of genotypes, there is need for quantifying the power trade-off between the number of genotypes and the number of biological ... markers surrounding the gene being tested with the remaining markers included in the model as a separate trans random effect [13] The approach for splitting cis and trans components in these studies ... Bimodal Gene Expression Patterns: Plot A shows the proportion of samples with missing values calculated for each gene The overall distribution of the missing rate is bimodal with the majority of genes

Ngày tải lên: 30/01/2023, 20:15

... promoter and the GFP tag, but without the Shh insert Therefore, presence of GFP in prostates indicated successful introduction of pCX-shh-IG vector and expression of Hh protein Intraprostatic injection ... whether P63+ basal/stem cells were activated under the influence of Hedgehog overexpression, we examined the pCX-shh-IG-injected prostates during the progression of PIN toward CaP to gain further ... expressed in the P63+ basal/stem cells of the pCX-shh-IG-injected prostates, being located in the cell membrane of P63+ basal cells in regions of primary PIN lesions (Figure 3B; arrow in (b) indicated

Ngày tải lên: 10/08/2014, 05:21

... treatment inhibited expression of transcription factors, Id proteins 2 to 4 (Table 7), binding protein Gremlin (Figure 2), and MAD genes. Changes in Id genes correlat ed wi th the earlier findings ... genes: Matrix degrading proteases, cathepsins, and apoptosis-related genes Among other catabolic genes influenced by OP-1 were the matrix metalloproteinases (MMPs), cathepsins, and a number of ... death. In many of these cases, OP-1 modulated the expression of not only the ligands, but also their receptors, mediato rs of downstream signaling, kinases responsible for an activation of the pathways,

Ngày tải lên: 12/08/2014, 15:22

... glycine to L-serine prior to its potential conversion to pyruvate, was found only in late phase growth Intriguingly, the enzymes involved in biosynthesis of the amino acids arginine, lysine and ... hypothetical conserved proteins The identification of such proteins within the cell-extract of O anthropi establishes the biological functionality of these 'hypothetical' predicted protein coding ... change in protein expression between proteins from the two growth conditions can be seen in Table Taking the ≥20% cut-off value, 44 proteins significantly changed in expression; at the ≥50% cutoff

Ngày tải lên: 14/08/2014, 07:21

... as the total number of genes in TAGs in each case minus the number of initial singleton genes, which can be estimated as one half of the number of genes in two- copy gene families. Screening ... genome. The interval of the data points in terms of K s of the curves is 0.01. Because initially genes are singletons and the duplication direction in TAGs is unknown, the number of duplicated genes ... retroposition. The rates are the slopes of the linear functions (red lines) fitted to the curves of the cumulative distributions of retrogenes. All of the linear functions are fitted to the part of the

Ngày tải lên: 14/08/2014, 08:20

... Clinicopathologic findings Clinical characteristics of patients included in the cohort and in the four validation cohorts, comprising a total of 833 HGG cases, are described in Table Both the ... partitions of the TCGA GBM cohort The histograms indicate distribution of the Cox coefficients and the corresponding statistical tests The median values of the P-values and Cox coefficients among the ... analysis of FBXO17 protein on HGG tumor specimens is required and deserves detailed investigation in the future The single -gene measurement assay is Page of 10 applicable in clinical practice and the

Ngày tải lên: 03/07/2020, 01:23

... using the Neighbor-Joining method The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (1000 replicates) is shown next to each of the nodes The ... translation The cDNA sequencing libraries were generated using the Illumina TruSeqTM genomic sample prep kit (Illumina, San Diego, CA, USA) following the manufacturer’s instructions The synthesized ... lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree The evolutionary distances were computed using the Poisson correction method and are in the units

Ngày tải lên: 18/10/2022, 17:03

... did not indicate the presence of any cofactors In fact, A vinosum is so far the only organism in which dsrS is part of the dsr gene cluster In other sulfur-oxidizing bacteria the gene is either ... does not induce sox gene expression in A vinosum Proteins encoded by Alvin_2166 and Alvin_2165 as potential regulators of sox gene expression The protein encoded by A vinosum gene Alvin_2166 is ... predicted for Alvin_2165 indicating a role of cyclic di-GMP as a second messenger (Römling and Amikam, 2006) in the regulation of the sox genes in A vinosum Homologs of Alvin_2166 and Alvin_2165 are

Ngày tải lên: 04/12/2022, 16:13

... examine the reg- ulation of these funcats in all of the sub-models. This analysis enabled us to determine into which sub-models the genes from these funcats fell and to determine whether the genes ... .. expression in treatment 2 minus the expression in treatment 1; see Figure 2), the expression due to nitrogen (the expression in treatment 2 minus the expression in ... expected because these genes are more closely related to each other than to the other genes in Model 3 CN-enhanced, and because their CN regulation is the result of the action of the same transcription

Ngày tải lên: 14/08/2014, 14:21

... that the lack of TNF-R1 does not affect the incidence or severity of collagen-induced arthritis in the joints [27] Repeated injections of TNF-α into the joints of TNF-R1 knockout mice enhanced the ... among the various age groups studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of ... on expression of interleukin-1 and interleukin-1 receptors The addition of recombinant TNF-α for 48 hours resulted in a significant upregulation of IL-1β and IL-1Ra genes in both normal and degenerate...

Ngày tải lên: 09/08/2014, 14:20

... novel insights into the regulation of disordered proteins This aim was achieved and we discuss our findings in the following sections Protein disorder and gene expression On consideration of the gene ... studied The increase in the decay rate of the transcripts encoding disordered proteins is likely attributable, in part, to the increase in predicted miRNA regulation The transcripts encoding disordered ... proteins being targeting for ubiquitination These properties play a role in the high levels of gene expression observed in the highly disordered proteins compared to proteins with less disorder The...

Ngày tải lên: 14/08/2014, 21:20

... streptomycin per ml and subsequent selection of single colonies onto plates resulted in loss of the integrated plasmid with an integration frequency of the interrupted nuoCD region in 50% of the integrants ... regions of NifL-protein are located in the N-terminal domain [31] that binds the FAD-cofactor [17], one can speculate that the N-terminal domain of NifL might enter the lipid bilayer and contact the ... cassette into the EcoRV site of fdnG fragment resulting in pRS177 The 3.2-kb EcoRI/KpnI fragment of pRS177 including the fdnG::tet region was cloned into pKAS46 The construction of the Ó FEBS...

Ngày tải lên: 17/03/2014, 10:20

... hrs after the administration of morning dose of insulin and curcumin The results were expressed in terms of milligram per decilitre of blood Total Dopamine receptor binding studies in the cerebellum ... receptor binding parameters were determined using Scatchard analysis [32] The specific binding was deter- Page of 11 mined by subtracting non-specific binding from the total The binding parameters, ... interest in learning dopamine D2 receptor expression begins with the hypothesis that dopamine D2 receptors are involved in the pathophysiology of schizophrenia and in the mechanism of antipsychotic...

Ngày tải lên: 10/08/2014, 05:21

... Comparison of gene expression in different nectary types Comparison of gene expression in different nectary types The number of genes displaying a two-fold or greater difference in expression in different ... significance of these elements occurring within the promoters of these genes Further information on the MYB4 and CArGCW8GAT promoter motifs are discussed below Discussion Gene expression profiles in different ... 'present' or 'absent' in all biological replicates of the nectary tissues examined (quality setting of 0.04 in Expressionist® Analyst software) The number of genes called 'present' in all replicates...

Ngày tải lên: 12/08/2014, 03:20

... number of genes in a given neuron and are, therefore, incomplete To test the applicability of the mRNA-tagging strategy for obtaining a comprehensive gene expression profile of a specific subset of ... 'mountains' based on similarities in gene expression [95] In some instances, co-regulated genes were grouped into specific functional subsets, thereby defining the 'name' of the mountain For ... the majority of genes in this interactome group are expressed in the nervous system favors the idea that these networks reflect authentic interactions in neurons We note that 13 of the proteins...

Ngày tải lên: 14/08/2014, 07:22

... determine whether we could detect any changes in gene expression before appearance of symptoms, we examined the gene expression profile of peripheral blood in the early preclinical stages of infection ... subtracting the average of the pre-infection baseline expression level from that animal, so that the values of each time point represent changes relative to the uninfected samples The genes whose expression ... R174 Rubins et al Cy3 signal over the pixels spanning the array element of ≥0.6 and intensity/background ratio of ≥2.5 in at least 80% of the arrays For each gene, the expression levels over the...

Ngày tải lên: 14/08/2014, 08:20

... value of the training samples in the case of continuous variables The aggregate forest's output is then determined by averaging the regression values of the trees or using a weighted voting process ... basis, the random forest determines the importance score of each gene (variable) in the multivariate model The distribution of importance scores of the genes in the category is then compared with the ... activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle J Clin Invest 1994, 94:277-285 Pugh BF: Control of gene expression through regulation of the TATA-binding protein Gene 2000,...

Ngày tải lên: 14/08/2014, 08:20