Post translational regulation of the human TRIP br1 cell cycle protein

... weight of 25.1 kDa and a pI of ~3.99 The murine TRIP- Br1 (mTRIP -Br1) orthologue is 86% identical to hTRIP -Br1 in amino acid sequence The other TRIP- Br family member, the human TRIP- Br2 (hTRIP-Br2) ... binding region of DP1 60 5.4 Other TRIP- Br1 binding partners - the p53 oncoprotein 61 5.5 50 Other TRIP- Br1 binding partners - the E6 oncoprotein 63 TRIP-...

Ngày tải lên: 14/09/2015, 13:56

... retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the hGnRH II gene, the expression vector of human ... on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-...

Ngày tải lên: 16/03/2014, 10:20

... Chem 27 8, 28 677 28 685 Cui X, Rouhani FN, Hawari F & Levine SJ (20 03) Shedding of the type II IL-1 decoy receptors requires a FEBS Journal 27 2 (20 05) 916– 928 ª 20 05 FEBS 24 25 26 27 28 29 30 31 32 ... found by RT-PCR FEBS Journal 27 2 (20 05) 916– 928 ª 20 05 FEBS T Tanioka et al Regulation of L-RAP ⁄ ERAP2 gene expression Fig Role of the IRF-E and Ets site...

Ngày tải lên: 23/03/2014, 13:20

... unwavering support of my goals iv ABSTRACT Sara M McNeil ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU8 0 CTERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU DNA double strand breaks ... than that of the 16 kDa Ku8 0CTR band and the band intensity generated from Ku7 0 and Ku8 0 C antibodies, indicating a small per...

Ngày tải lên: 24/08/2014, 11:02

... Pochareddy TRANSCRIPTIONAL REGULATION OF THE HUMAN ALCOHOL DEHYDROGENASES AND ALCOHOLISM Alcohol dehydrogenase (ADH) genes encode proteins that metabolize ethanol to acetaldehyde Humans have ... Accumulation of the ECM proteins alters the morphology of the liver, leading to the development of fibrotic liver 10 Alternative transcript isoforms and diseases On...

Ngày tải lên: 24/08/2014, 12:37

... of the TRIP- Br proteins 17 2.3 The functional properties of the TRIP- Br proteins 18 2.3.1 The unique ability to interact with the PHD zinc 18 finger and/ or the bromodomain iv 2.3.2 The TRIP- Br ... potentials of the TRIP- Br proteins 2.4 The TRIP- Br proteins: a novel class of cell cycle regulator 21 2.4.1 The mammalian cell cycle...

Ngày tải lên: 16/09/2015, 17:12

... Attenuation of LXF-289 cell proliferation by ATP is mediated by the activation of the MEK ⁄ ERK1 ⁄ 2, PI3K and p38 MAPK pathways Activation and translocation of the transcription factors NF -jB1 (p50) and ... Table Inhibition of proliferation of LXF-289 lung tumor cells Effects of signaling pathway inhibitors on ATP-inhibited proliferation (A)...

Ngày tải lên: 07/03/2014, 12:20

... presence of AMP (0, 50, 200 or 500 lM AMP) Table Effect of the mutations in the AMPK c3 gene on the AMP dependence of the enzyme Fold stimulation reflects the activation of the corresponding AMPK complexes ... AICAR- and contraction-induced a2-AMPK signaling [49] Initially, AMP was thought to increase phosphorylation of AMPK by AMPKK both by direct...

Ngày tải lên: 30/03/2014, 08:20

... HERV-Kcon HERV-Kcon HERV-Kcon pro- lys sup lys lys sup + + - + lys sup lys sup + 148 kDa 98 64 Gag polyprotein 98 64 Gag polyprotein 50 50 36 kDa 148 36 Gag CA Gag CA 22 22 Figure HERV -K Gag polyprotein ... is rather p pH p pH 10 148 kDa 98 64 50 36 16 B Zn Finger Z Fi myristylation Matrix (CYNCGQIGHLKKNC) (CPRCKKGKHWASQC) P15 Capsid NC Sp1 HERV K Gag Figure Mapping of HERV...

Ngày tải lên: 13/08/2014, 01:20

... Yamada Y, Ikeda S, Yamasaki Y, Tsukasaki K, Tanaka Y, Tomonaga M, Yamamoto N, Fujii M: Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLVI -infected T -cell lines and ... primary adult T -cell leukemia cells Blood 2002, 100:1828-1834 Mori N, Fujii M, Iwai K, Ikeda S, Yamasaki Y, Hata T, Yamada Y, Tanaka Y, Tomonaga M, Yamamoto N: Constitutiv...

Ngày tải lên: 10/08/2014, 05:21

... GJ, Hammond SM: A microRNA polycistron as a potential human oncogene Nature 2005, 435:828-833 Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y, ... HAS2 -A HDAC4 -A HDAC4-B HDAC4-C HDAC4-D HIF1 -A HIF 1A- B IRF1 -A KHDRBS1 -A KHDRBS1-B KPNA2 -A MAP3K8 -A MAP3K8-B MAPK9 -A MYCN -A MYCN-B NCOA3 -A NCOA3-B NCOA3-C NCOA3-D NR...

Ngày tải lên: 14/08/2014, 20:22

... cutaneous and intracavitary superficial mucosal lesions such as vulvar intraepithelial neoplasia, cervical dysplasia or carcinoma in situ, oral cancer and nasopharyngeal bladder cavity mucosal ... studies of the integrator function of TRIP- Br transcription factor as therapeutic drug target for the treatment of human cutaneous and intracavitary superficial lesio...

Ngày tải lên: 12/09/2015, 08:19

... endocannabinoid system, we investigated the presence and regulation of endocannabinoids, cannabinoid receptors and FAAH in immature and mature dendritic cells obtained by stimulation with either the ... min), two fractions were obtained: a top leukocyte band containing mononuclear cells (monocytes and lymphocytes) and a lower band containing polymorphonuclear le...

Ngày tải lên: 22/02/2014, 07:20

... to enable them to act as sensing components for the HIF system [3,4] In addition to HIF-a, FIH also catalyses the hydroxylation of conserved Asn residues within the ubiquitous ankyrin repeat domain ... Asn hydroxylation sites (Fig 1A) [8] The positioning of these His residues within the hydroxylation consensus, coupled with the structural similarity between...

Ngày tải lên: 28/03/2014, 23:20

... shown that the inflammatory cytokines increase the expression of CD38 in human airway smooth muscle cells [5,7,8] The regulation of CD38 expression by TNF-α in HASM cells involves NF-κB and AP-1 ... stimuli is a hallmark of asthma In this regard, airway smooth muscle has a role in the regulation of airflow and in maintaining airway cal...

Ngày tải lên: 12/08/2014, 15:21