anatomy of the human heart pdf
Báo cáo khoa học: The protein shuffle Sequential interactions among components of the human nucleotide excision repair pathway pdf
... late steps of the process. For example, early in the NER process, RPA assists TFIIH in the opening of the DNA helix around the damage site [36]. Further-more, in the presence of the XPA minimal ... sites.Taken together, these findings suggest that the struc-tural properties of DNA-damaged substrates, whetherintrinsic or the result of protein binding, function in the recruitment of the XPC–hHR23B ... Binding of XPG induces the release of XPC–hHR23B, whereas XPF–ERCC1 triggers exci-sion of the damaged DNA and the release of XPAand TFIIH. Subsequently, the newly formed gap in the DNA is filled by...
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Báo cáo Y học: Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate pdf
... increases the rate of transcription initiation of the PS1 gene in SK-N-SH cellsTo determine whether the increase in the level of PS1mRNA results from the activation of the transcription of the gene ... in the presence of TPA. Thus the increase in the level of PS1 mRNA observed by Northern blotting of totalcellular RNA results from an increase in the rate of initiation of transcription of PS1.PS1 ... Hence the identification of the mecha-nisms controlling the expression of the PS1 gene shouldrelate directly to understanding further the developmentand differentiation pathways and the pathogenesis...
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Báo cáo khoa học: Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2¢ of substrates pdf
... number of poten-tial substrates during the screening of the full human proteome. This highlights the importance of factorsother than the extended cleavage specificity in deter-mining whether ... in 6% of the sequences. Thus, Arg143 and Lys192 contributealmost equally to the P2¢ specificity of HC. Mutatingeither of the two basic amino acids in these positionspartially disrupts the acidic ... orGlu, but attract these residues equally well, probablysolely on the basis on the negative charge of their sidechains.Verifying the consensus sequence by the use of anew type of recombinant...
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Báo cáo y học: "Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus"
... all of the OLP epithelium. The count was performed by two investigators without knowledge of whether the samples were control or experimental. The total number of basal and suprabasal epithelial ... Negative controls consisted of omission of the primary or the secondary antibody or primary incubation in the presence of non-immunized rabbit serum instead of the primary antibody. Cell quantification ... OLP would require an increased immunolocalization of hMSH2. Therefore, the reduced expression of hMSH2 protein could make the epithelium of OLP more susceptible to DNA mutation, making it prone...
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Tài liệu Decision Analysis and Risk Management: Two Sides of the Same Coin pdf
... based on analysis of risk. The thoroughness of the analysis determines the “quality” of the decisions.High quality decisions are not the best decisions in hindsight. They are the best decisions ... decisions in which the magni-tude of the risk of being wrong is understood. The quality of decisions can therefore be judged by the degree to which uncertainties (risks) are considered in the decision ... then related to the four steps of the decision making process and finally to the three types of error (risk) that occur in each of the four steps. The paper concludes with an example of how methodical...
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Tài liệu McGraw.Hill.Mathematics.Of.The.Securities.Industry pdf
... to the right of the decimal is less than 5 (4,3, 2, 1, or 0), then ignore all digits after the second one to the right of the decimal.Example: In the number 98.74285, the third digit after the ... digits to the right of the decimal place, for example,98.74 rather than 98.74285.To round off to two decimal places, you must examine the third digit to the right of the decimal.●If the third ... date. The company announces the amount of the div-idend, the record date, and the payment date. Soonthereafter, a fourth date, the ex-dividend date, is set byeither a stock exchange or the National...
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Tài liệu Multimedia Applications of the Wavelet Transform pdf
... [Sch01d].A historic overview of the development of the wavelet theory precedes the introduction of the (one–dimensional) continuous wavelet transform. Here, the definition of a wavelet and basic propertiesare ... between the wavelet transform and the Fourier transform are usually restricted to the special case of the STFT. The calculation of the Heisenberg boxes of time–frequency uncertainty for the STFT ... reduce the time–spread of , a scaling factor is introduced. If we denote the total energy of the signal by(i.e., the canonical norm in ), and aim to keep the totalenergy of bothand the time–scaled...
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Tài liệu Anatomy of a Robot P2 pdf
... sys-tems is the queen of the sciences—mathematics. Given an understanding of the math,we can tame any of these types of control systems. In the final analysis, they all behave the same way, ... model the energy of both motions separately. You canuse the center of gravity of the mass and see how fast that is moving linearly.Then you can add the energy of rotation about that center of ... feature into the elevator system. Since there were only two floors, whyeven bother putting in floor buttons? Just sense the motion of people coming into the elevator, and take them to the other floor....
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Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf
... rows in the race ought to live till the age of 60;and if all the members of the Oxford 1829 crew hadlived till the 10th of June, 1869, the 40th anniversary of the race, and then died, their lives ... UniversityMatches came off, in which 32 crews competed. In the case of each of these crews I have calculated the pro-bable duration of life of the different Oarsmen of whomthey were composed: the following ... good reasonmay the British mother bewail the murder of her inno*cents and denounce the callous indifference of those towhom their education is entrusted. As a further proof of the dangers which...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
... respectively, of that of HPRT. This low activitycould be explained by the fact that PRTFDC1 has a Gly in the position of the proposed catalytic Asp of HPRT. In PRTFDC1, a water molecule at the position of ... spectrophotometric methods.Because the enzymatic activity of PRTFDC1towards hypoxanthine and guanine is only 0.26% and0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism ... activity [10]. The structural characterization of numerous com-plexes of the human HPRT and several bacterial andprotozoan HPRTs have been undertaken [13–17]. The structure of human HPRT can...
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Tài liệu THE HISTORY OF THE RISE, PROGRESS, AND ACCOMPLISHMENT OF THE ABOLITION OF THE SLAVE-TRADE pdf
... was the readiest way of converting them to the principles of the Christian religion. These, then, were the first forerunners in the great cause of the abolition of the Slave Trade: nor have their ... held the reigns of the government of Spain till Charles the Fifth came to the throne, for the establishment of a regular system of commerce in the persons of the native Africans. The object of ... nature of it; and of the extent of it; and of the difficulty of subduing it.—Usefulness also of the contemplation of this subject. I scarcely know of any subject, the contemplation of which...
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Tài liệu Inequalities in Higher Education and the Structure of the Labour Market pdf
... especiallythosewhoholdgeneralbachelor’sdegrees,theirqualificationsserveonlyasasignal of theirpotentialtoemployers.Inmanycases,theytakelongertorealiseemploymentandwhentheydotheirentryleveljobsdonotnecessarilyrequire the years of schoolingtheypossess.Theystartat the bottom of the jobladderandhavetoprovethemselvesin the labourmarkettoreachhigherincomelevels.Acombination of theirpotentialandtrainingwilldeterminetheirprogressionup the ladder.Aswillbeseenin the nextsection, the field of study,whichsignals the type of skillsacquiredthrougheducation,playsasignificantroleinemployability of universitygraduatesinthiscase.PercyMolekeFree ... 7,5Sector of employment The role of the publicsectorasanemployeris of particularinterest.Itis the firstsector of employmentforalargeproportion of graduatesirrespective of field of study,raceandgender.ThisisespeciallytrueforAfricangraduateswhomakeup ... 3,6*EMS:EconomicandmanagementsciencesPerceptions of the value of highereducation The graduateswereaskediftheywould choose the same or a different course of study if they could start again, toestablish the value theyplaced...
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