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Regulation of na+ h+ exchanger 1 (NHE 1) gene expression by mild oxidative stress

Regulation of na+ h+ exchanger 1 (NHE 1) gene expression by mild oxidative stress

Regulation of na+ h+ exchanger 1 (NHE 1) gene expression by mild oxidative stress

... Regulation of activity and expression of NHE 1 54 1. 4.4 A 1. 4.4 B 1. 5 Regulation of NHE -1 activity 54 Transcriptional regulation of NHE -1 expression .58 AIM OF STUDY 61 ... response repression of NHE -1 expression .11 1 Figure 13 : Thiol oxidizing agent diamide mimicked the effect of H2O2 in the downregulation of NHE -1 gene expression 11 3 Figu...

Ngày tải lên : 14/09/2015, 08:50

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Regulation of na+ h+ exchanger 1 (NHE1) stability in PTEN mouse embryonic fibroblasts

Regulation of na+ h+ exchanger 1 (NHE1) stability in PTEN mouse embryonic fibroblasts

... exchanger- 1 (NHE1) 1. 1 .1 NHE1 isoforms and NHE1 structure 1. 1.2 Regulation of NHE1 1. 1.3 Physiological function of NHE1 1. 1.4 Role of NHE1 in cancer progression 11 ... formation of Hsp90/Akt/NHE1 complex in MCF10AT1 12 4 3.3.3 Akt regulates NHE1 protein expression in MCF10CA1a 13 1 3.3.4 NHE1 interacts with Akt in MCF10CA1a and not MCF10CA1h 13 4 3.3.5...

Ngày tải lên : 10/09/2015, 09:29

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Redox regulation of estrogen receptor alpha and sodium hydrogen exchanger 1 gene expression by hydrogen peroxide

Redox regulation of estrogen receptor alpha and sodium hydrogen exchanger 1 gene expression by hydrogen peroxide

... REGULATION OF NHE1…………… 11 0 3B .1 DOWN -REGULATION OF NHE1 BY H2O2 11 0 3B .1. 1 Identification of crucial region in the promoter of NHE1 11 0 3B .1. 2 H2O2 down-regulates 0 .15 kb proximal NHE1 promoter ... signaling 21 1.3.4 Regulation of estrogen receptors 23 1. 3.5 Estrogen and estrogen receptors in human breast cancer 27 v 1. 4 THE SODIUM HYDROGEN EXC...

Ngày tải lên : 10/09/2015, 15:49

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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 1

THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 1

... 1. 1.5 Ligands and physiological functions of PPARα and PPARδ 1. 1.6 Ligands of PPARγ 1. 1.7 PPARγ and adipogenesis 10 1. 1.8 PPARγ and insulin sensitization 12 1. 1.9 ... PPARs and cancer 13 1. 1 .10 PPARγ and breast cancer 15 1. 2 ESTROGEN RECEPTORS (ERS) 18 1. 2 .1 Identification and structures of ERs 18 1. 2.2 Mechanism of action of ... PPARγ -...

Ngày tải lên : 09/09/2015, 10:19

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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 2

THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 2

... ROS/RNS 10 5 contributes approximately 20 % of the overall downregulation of NHE1 transcription by 5M of 15 d-PGJ2 10 6 Figure 11 : ROS/RNS contributes to downregulation of NHE1 (A) MCF-7 (3 X105 cells/6-well ... (Figure 11 C) In contrast, 15 d-PGJ2 caused 61% reduction in NHE1 mRNA in the absence of NAC We reasoned that this difference in magnitude of dow...

Ngày tải lên : 09/09/2015, 10:19

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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 4

THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 4

... EFFECT OF PPARγ ON NHE1 Given that the presence of estrogen blocked the downregulation of NHE1 expression induced by PPARγ lgiands, we next investigated the role of estrogen receptor in PPARγ -mediated ... protein and mRNA is mediated by estrogen recptor alpha 13 1 Figure 19 : Re-expression of ERα blocks PPARγ -mediated downregulation of NHE1 ex...

Ngày tải lên : 09/09/2015, 10:19

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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 6

THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 6

... basis and biological significance." Oncogene 25( 51) : 67 31- 67 48 Bunone, G., P A Briand, et al (19 96) "Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct ... hepatotoxicity: another lesson from troglitazone." Diabetologia 51( 11) : 210 8 211 6 Jurka, J and A Milosavljevic (19 91) "Reconstruction and analysis of human...

Ngày tải lên : 09/09/2015, 10:19

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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 3

THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 3

... to 15 d-PGJ2, while 15 d-PGJ2 resulted in the maximal reduction in the number of colonies formed by MDA-MB-2 31 cells expressing the highest level of PPARγ receptor 11 2 Figure 14 : PPARγ agonists ... cells and only a 36 % downregulation in T47D cells (Figure 14 D) Interesetingly, the extent of inhibition on cologenic ability of different breast cancer cell...

Ngày tải lên : 09/09/2015, 10:19

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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 5

THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 5

... PPARγ -mediated NHE1 downregulation From the results shown above, we concluded further that the DNA binding ability of ERα is involved in inhibiting PPARγ -mediated NHE1 repression 15 1 15 2 Figure ... 30% reduction in NHE1 mRNA in ER positive MDA-MB-2 31 cells It is interesting that in the absence of fulvestrant, 1 M of 15 d-PGJ2 brought down NHE1 mRNA to 50 % of...

Ngày tải lên : 09/09/2015, 10:19

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Retrovirology Commentary BioMed Central Open Access Inhibition of HIV-1 gene expression by pptx

Retrovirology Commentary BioMed Central Open Access Inhibition of HIV-1 gene expression by pptx

... Sam68ΔC Understanding regulation of Understanding regulation of HIV-1 gene expression by Sam68ΔC (A) Following transcription, HIV-1 RNA undergoes alternative splicing to generate over 40 mRNAs that ... next page) Page of (page number not for citation purposes) Retrovirology 2009, 6:22 http://www .retrovirology. com/content/6/1/22 Figure (see previous page) HIV-1 gene ex...

Ngày tải lên : 12/08/2014, 23:20

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Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx

Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx

... replication by drugs that block eIF5A modification Inhibition of HIV replication by drugs that block eIF5A modification A Hypusination of eIF5A (gray) occurs in two steps: the transfer, catalyzed by DHS, ... DHS, of an aminobutyl moiety (blue) from spermidine onto the side chain of eIF5A lysine-50, yielding deoxyhypusine (Dhp); and its subsequent hydroxylation, cat...

Ngày tải lên : 12/08/2014, 23:22

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Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death

Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death

... I.5 Na+- H+ Exchanger (NHE) The Na+- H+ exchangers (NHEs) are a family of membrane glycoproteins which transport H+ out of the cell in exchange for Na+ with a stoichiometry of 1: 1 In mammalian cells, ... increased 11 2 susceptibility to cell death IV .12 Regulation of intracellular pH as one of the mechanisms of 11 3 NHE- 1 -mediated cell...

Ngày tải lên : 16/09/2015, 08:31

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Báo cáo Y học: Properties of the Na+/H+ exchanger protein Detergent-resistant aggregation and membrane microdistribution potx

Báo cáo Y học: Properties of the Na+/H+ exchanger protein Detergent-resistant aggregation and membrane microdistribution potx

... is usually the result of their hydrophobicity [28,33] The Na+/H+ exchanger is predicted to have 12 transmembrane segments and one membrane- associated Fig Colocalization of the Na+/H+ exchanger ... of membrane fractions from methyl b-cyclodextrin-treated cells of the Na+/H+ exchanger, biochemical characterization of the properties of the full length...

Ngày tải lên : 08/03/2014, 16:20

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Báo cáo y học: "Regulation of chondrocyte gene expression by osteogenic protein-1" ppt

Báo cáo y học: "Regulation of chondrocyte gene expression by osteogenic protein-1" ppt

... differentially regulated by the two treatment conditions: rhOP-1 down-regulated LIF expression by more than 15-fold, IL-11 expression by more than eight-fold, IL-8 gene by four-fold and IL-6 by two-fold, ... Pathway analysis and classification by gene ontology Regulated genes (R > 1.5-fold, P < 0.001) were used as input for both analyses The ingenuity pathway analysis syst...

Ngày tải lên : 12/08/2014, 15:22

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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

... cyclin D1 gene promoter We studied the mechanism(s) underlying the inhibition of cyclin D1 gene expression by EPA and DHA by examining the effects of n-3 and n-6 PUFAs incorporation on cyclin D1 promoter ... control of SMC proliferation 4466 S Bousserouel et al (Eur J Biochem 271) Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb...

Ngày tải lên : 19/02/2014, 16:20

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