Intra cellular endoplasmic reticulum dynamics, distribution and function in response to cell engineered surface adhesion

... α-actinin with integrin; green lines indicate the binding of talin, α-actinin and vinculin with actin filaments; and blue lines indicate the binding of vinculin with talin and α-actinin The indirect ... of integrins to actin cytoskeleton via the recruitment of interacting cytoskeletal proteins including talin, vinculin and α-actinin (Ziegler et al., 2008) Integrin β subunit binds to talin and ... arrangement in response to cell adhesion (A) Actin filaments interact with integrins indirectly via adaptor proteins talin, α-actinin and vinculin Red lines indicate the direct binding of talin and α-actinin...

Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

... Discussion The main ﬁnding of this study is the identiﬁcation of a metabolic gene switch from fatty acids to glucose in the murine female heart at baseline linked to enhanced mitochondrial respiratory ... al Metabolic gene switching in murine female heart function [8] Likewise, high fatty acid oxidation rates in the diabetic heart results in reduced cardiac efﬁciency [9] In addition to its cytoplasmic ... compared to males (Fig 2F) Interestingly, we found that gene changes in the female heart were abolished with the onset of obesity ⁄ type diabetes Together, these data suggest that murine female hearts,...

báo cáo khoa học: " PR genes of apple: identification and expression in response to elicitors and inoculation with Erwinia amylovora" doc

... http://www.biomedcentral.com/1471-2229/6/23 Figure Expression of apple PR genes in response to inoculation with plant pathogenic bacteria Expression of apple PR genes in response to inoculation with plant pathogenic bacteria ... PR- 8 following inoculation of apple shoots with Erwinia amylovora by three different methods Figure Expression of PR- 2 and PR- 5 and PR- 8 following inoculation of apple shoots with Erwinia amylovora ... not induced in response to inoculation with E amylovora In contrast to the robust induction of PR- 2, PR- 5 and PR8 , PR- 1a was not induced during the first 96 hours following inoculation of young...

Investigate the function of kinectin isoforms in endoplasmic reticulum dynamics

... brings the total known number of kinectin isoforms in mouse to 16 (Fig 1.2) The identification of total of 16 kinectin isoforms reveals the long-suspected existence of a family of kinectin isoforms ... kDa kinectin of Int4 at the leading edge of migrating cells 60 Chapter Roles of kinectin Int4 in ER dynamics during cell migration and division 63 3.1 Roles of kinectin Int4 in ER dynamics ... demonstrated the importance of kinectin isoforms with Int4 in modulating ER dynamics of interphase cells These findings would serve as a platform for more detailed studies of kinectin isoforms The opportunities...

Báo cáo khoa học: Paralog of the formylglycine-generating enzyme – retention in the endoplasmic reticulum by canonical and noncanonical signals pptx

... C-terminal His6-tag impaired retention of pFGE, indicating that the C-terminus of pFGE might be involved in the ER retention mechanism pFGE carries canonical or noncanonical ER retention signals in ... 1121 ER retention by noncanonical retention signals S L Gande et al form of pFGE was secreted during the pulse, and most of these forms were retained intracellularly after h of chase (88% and 66%, ... not affect binding of DDEL-containing ligands in vitro and in vivo, which suggests that different retrieval signals make different contacts in the binding pocket The variability in the retrieval...

Báo cáo khoa học: Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana ppt

... protein response genes in Arabidopsis vesicle trafﬁcking ⁄ transport, vacuolar protein sorting, cell wall biogenesis, and lipid ⁄ inositol metabolism In comparison with those of yeast, the UPR genes ... analysis In addition to the genes related to protein folding and degradation, genes related to protein translation and apoptosis are also included in the list Results Fluid microarray analysis of gene ... containing the P region of calreticulin, which is a model of a misfolded 3469 Unfolded protein response genes in Arabidopsis protein in the ER, was shown to be retrotranslocated to the cytosol,...

Reproductive System Structure, Development and Function in Cephalopods with a New General Scale for Maturity Stages pot

... reproductive strategies within coleoid cephalopods and for developing a general scale for maturity staging for males and females Materials and Methods Details of the structure of the reproductive system ... in Cephalopods TABLE A general scale of maturity stages for male and female cephalopods (AG gland, SP = spermatophore, SOC = spermatophoric organ complex.) 71 =accessory glands, oviducal glands, ... different parts of the reproductive system can be divided into stages which are functionally similar in males and females With the foregoing considerations, a general scale for maturity stages is...

Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc

... Cite this article as: Bonanno et al.: Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies Journal of Translational Medicine 2010 8:114 Submit ... implication of our findings pertains to HLA-matched stem cell transplantation, a clinical context where pegfilgrastim administration may modulate the number of immune cells and/ or levels of immune ... (Th2) cytokine production [3] In humans, G-CSF increases interleukin (IL)-4 release and decreases interferon (IFN)-g production [4], induces immune modulatory genes in T cells, including the Th2...

Báo cáo lâm nghiệp:" Structure, spatial distribution and competition in mixed jack pine (Pinus banksiana) stands on clay soils of eastern Canada" pps

... species in 68-years old pure jack pine stands, stands mixed with aspen and stands mixed with white birch The spatial distribution of trees in jack pine stands mixed with aspen shows that jack pine ... repulsion is present only on one stand Table II Effect of stand type on skewness of basal area distribution of the three main tree species in pure jack pine stands and stands composed of a mixture of ... basal area distribution of jack pine between pure jack pine stands and stands composed of a mixture of jack pine and either of white birch or aspen Trembling aspen basal area distribution did not...

Báo cáo y học: "Leukocyte numbers and function in subjects eating n-3 enriched foods: selective depression of natural killer cell levels" potx

... processed with Lysis II software (BD Biosciences) To determine leukocyte and lymphocyte numbers, 130 μl of whole blood was aspirated and analyzed using a hematology analyzer CELL- DYN 3500SL (Abbott ... LCPUFA levels in erythrocyte membranes and LT production by lymphocytes The discrepancy in the pattern of regression – that is, linear in the case of LT or U-shaped in that of PHA-induced proliferation ... 8.04% The reduced NKcell numbers can only be contributing in a very small way to the reduced levels of total leukocytes and lymphocytes seen over this range of n-3 LCPUFA, EPA and DHA levels While...

Form And Function In A Legal System - A General Study Part 1 pdf

... function in a legal system – a general study This book addresses three major questions about law and legal systems: (1) What are the deﬁning and organizing forms of legal institutions, legal rules, interpretive ... overall forms of functional legal units, and on the overall form of a legal system as a whole, as major avenues for advancing understanding Form- oriented” analysis19 is applied here to a wide range ... implicit in what I have said so far The overall forms of functional legal units and the overall form of a legal system as a whole are, as Jhering plainly saw, of major theoretical and practical importance...

Form And Function In A Legal System - A General Study Part 2 pps

... functional legal units, and (6) in integrating and coordinating such units within a duly systematized operational system Form and the formal in functional legal units, and in a legal system as a whole, ... in 22 23 24 OED, supra n 2, vol 6, at form I.13; id., vol 6, at “formal” A. 3 .a P Atiyah and R Summers, Form and Substance in Anglo-American Law: A Comparative Study of Legal Reasoning, Legal ... arrangement of a functional legal unit is analogous Just as the form of a table may be said to arrange and shape the wood, and the form of a citadel may be said to arrange and shape the building...

Form And Function In A Legal System - A General Study Part 3 ppsx

... units and the performances of participants in the system? What roles forms play in the systematization of a legal system as such? How can an understanding of forms cast light on the general nature ... interpretation A form- oriented approach is oriented to the dynamic, integrative, and systematized nature of law-making and law-implementing activities that always involve diverse functional units ... form of the unit as a whole, including these features and their inter-relations Given the vast academic literature on legislatures in political and in legal studies, and also in comparative institutional...

Form And Function In A Legal System - A General Study Part 4 potx

... arbitrary They call for identifying and articulating reasons for and against alternative choices of form and content, and for the weighing and balancing of such reasons The overall form of a statutory ... of pre-emptoriness, see P Atiyah and R Summers, Form and Substance in Anglo-American Law: A Comparative Study of Legal Reasoning, Legal Theory, and Legal Institutions, 16–17 (Clarendon Press, ... explicit, usually in writing (or printing), and in appropriate grammar, syntax, and vocabulary of a common language of the system, at least when the rule is state-made, as opposed to privately made,...

Form And Function In A Legal System - A General Study Part 5 ppsx

... scrutinizing, debating, amending, and adopting a statute Such drafting also facilitates learnability of the law and the pre-emptoriness of those legal reasons for determinate action that arise for addressees ... reinforcive and regulative The Purpose of Creating and Maintaining Discrete Functional Legal Units and a Legal System as a Whole Without resort to the overall form of reinforcive rules, including ... ﬁlling a gap in it a court opinion creating, developing, or applying common law a regulation adopted by an administrative agency or ofﬁcial an opinion of an administrative agency creating, developing,...

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