Regulation of autophagy by lipid species

... in the regulation of autophagy (Yang and Klionsky, 2010a) Recent studies on the regulation of autophagy have also uncovered the existence of MTORC1-independent regulation of mammalian autophagy ... different stages of the autophagy process in mammalian cells Figure 2: Common signaling pathways involved in the regulation of autophagy Figure 3: Summary of the dif...

Ngày tải lên: 10/09/2015, 09:29

... 6075 p53, p73 and HIPK2 in apoptosis N Bitomsky & T G Hofmann Fig Regulation of DNA damage- induced cell death by p53 and HIPK2 Genotoxic stress-induced DNA damage facilitates activation of the DNA ... (2009) 607 4–6 083 ª 2009 The Authors Journal compilation ª 2009 FEBS N Bitomsky & T G Hofmann p53, p73 and HIPK2 in apoptosis Fig Regulation of...

Ngày tải lên: 16/03/2014, 00:20

... levels is mainly achieved by modulation of secretases, namely by the induction of a-secretase activity, by inhibition of b -secretases and ⁄ or c -secretases, or by a combination of both This study provided ... Regulation of secretases by retinoic acid A Koryakina et al use of several potential PKC activators, such as phorbol esters Therefore, an assessment of...

Ngày tải lên: 16/03/2014, 01:20

... of DNp63a by TNF-a was attenuated by inhibition of NF-jB, suggesting that activation of NF-jB may be involved in the regulation of the degradation of DNp63a Interestingly, knockdown of DNp63a expression ... function of DNp63a for epidermal stem cell proliferation, we were interested to know whether factors involved in maintaining epidermal homeostasis affect...

Ngày tải lên: 16/03/2014, 06:20

... expression by small RNAs - possible roles of miRNAs in psoriasis An extensive and important group of non-coding RNAs (ncRNAs) appeared with the discovery of miRNAs More than 700 different miRNAs have ... Cite this article as: Bak and Mikkelsen, Regulation of cytokines by small RNAs during skin inflammation Journal of Biomedical Science 2010, 17:53 Page 19 of...

Ngày tải lên: 10/08/2014, 05:21

... of metabolic Insulin signaling pathway used for the steady state analysis Schematic representation of metabolic Insulin signaling pathway used for the steady state analysis Nomenclature: I, Insulin; ... pathway or by amplification of residual signal Our analysis indicates that the inherent feedback structure present in the insulin-signaling pathway by itself ca...

Ngày tải lên: 13/08/2014, 22:22

... representation of two endocytosis pathways (a) Cargo trafficking mediated by clathrin-dependent endocytosis This pathway is typically initiated by the recruitment of cargo into clathrin-coated ... caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae J Cell Biol 2005, 168:477-488 18 Wu X, Gan B, Yoo Y, Guan JL: FAK-Mediated Src phosphor...

Ngày tải lên: 14/08/2014, 16:20

... to thank my family: Mom, Vinnie, Libby and Chanel, Grandma Elaine, Suz and Vince v ABSTRACT Jenna Lee Jewell REGULATION OF EXOCYTOSIS BY SYNTAXIN 4-MUNC18C COMPLEXES Type diabetes involves defects ... Accessibility but not VAMP2 Docking/Fusion at Syntaxin Sites Figure 4-9 125 Model Depicting Potential Mechanism of Regulation of Insulin Exocytosis by F-actin -Syntaxin...

Ngày tải lên: 24/08/2014, 11:41

... Primary miRNAs are transcribed and processed by Drosha and DGCR8 to form pre-miRNAs pre-miRNAs are transported out of nucleus by RAN-GTP and Exportin-5 and further processed by Dicer and loaded ... are shown32 5.6 microRNAs in erythropoiesis microRNAs are a class of small non-coding RNAs involved in the regulation of many biological processes through the downregu...

Ngày tải lên: 10/09/2015, 09:23

... phosphorylation by Prk1p and possibly Ark1p kinase These kinases constitute a unique family of actin regulating kinase whose substrates include many components of actin machinery as well as endocytic and ... depolymerization Actin bundling proteins such as Sac6p and Abp140p can be found coating the actin cables, and bind actin filaments together to form a cable...

Ngày tải lên: 14/09/2015, 08:50

... 5 2-6 8-6 119 4-6 5-6 221 2-6 7-1 376 6-8 1-2 158 2-0 9-8 186 1-4 0-1 6606 3-0 5-6 191 2-2 4-9 1597 2-6 0-8 9788 6-4 5-8 101 4-7 0-6 12 2-1 4-5 8578 5-2 0-2 292 1-8 8-2 2824 9-7 7-6 2735 5-2 2-2 4048 7-4 2-1 2293 6-7 5-0 3280 9-1 6-8 ... test to quantify the ecotoxicity level of river water from an urban area in...

Ngày tải lên: 05/09/2013, 10:15

... found to be 2.7 ± 1.8 nm, depicting a strong interaction between 2A2 mAb and cathepsin < /b> B Determination of < /b> the 2A2 mAb binding site on cathepsin < /b> B The binding site of < /b> 2A2 mAb on cathepsin < /b> B was determined ... exopeptidase activity of < /b> cathepsin < /b> B in the presence of < /b> 2A2 mAb Furthermore, 2A2 mAb also inhibited cathepsin...

Ngày tải lên: 18/02/2014, 11:20

... deaminase, dTTP regulation occurs by binding of the inhibitor to an allosteric site in competition with the activator dCTP [7] For dCTP deaminase, the mechanism of dTTP regulation is not understood ... in a slow transformation from an inactive to an active enzyme dTTP inhibition may then be achieved by stabilizing the inactive form of pr...

Ngày tải lên: 18/02/2014, 16:20

... solution On the other hand, the acceleration of the sliding velocity (and the lower number of stops) of thin filaments could be related to a diminution of the load in the actin–myosin interface The properties ... remained in the pellet independently of the other components and the ionic strength of the mixture In the presence of ATP, the amount of bo...

Ngày tải lên: 19/02/2014, 16:20

... mechanism of regulation of both domains involves a common iron dependent process [74,75,79] Regulation of HIFa subunits by oxygen-dependent prolyl and asparaginyl hydroxylation A variety of oxygen ... Moreover, Fig Regulation of hypoxia inducible factors (HIF) by oxygen-dependent hydroxylation In oxygenated conditions (normoxia) the asparaginyl and HIF...

Ngày tải lên: 20/02/2014, 23:20