The role of b cells in the pathogenesis of atherosclerosis

... Marginal Zone B cells 11 1. 4 Humoral Immunity in Atherosclerosis 12 1. 4 .1 Localization of < /b> B cells in Atherosclerosis 12 1. 4.2 Association of < /b> oxLDL-specific antibodies with Atherosclerosis ... further delineates the < /b> B1 population into B1 a (CD5+) and B1 b (CD5-) sub-populations B1 cell populations, unlike B2 cells, are not maintained thro...

Ngày tải lên: 10/09/2015, 09:23

... plasma cells in the < /b> bone marrow of < /b> apoE-/- mice Because we maintained the < /b> mice on BrdU in drinking water for one month, the < /b> result is also indicative that these plasma cells accumulated in the < /b> bone ... and/or increased bioavailability of < /b> 7α, 25 -OHC 3.4.1 Increased ch25h mRNA expression in the < /b> spleen of < /b> apoE-/- mice We exami...

Ngày tải lên: 10/09/2015, 09:24

... observed in the < /b> spleen of < /b> apoE-/- mice may be due to the < /b> inability of < /b> B cells to fall into the < /b> state of < /b> anergy However, it remains to be determined if APOE protein is crucial in maintaining the < /b> ... observed an increased frequency of < /b> oxLDL-specific oxLDL ASCs in the < /b> bone marrow in apoE-/- mice, indicative of < /b> thei...

Ngày tải lên: 10/09/2015, 09:24

... detected in this study The most notable findings were increased < /b> percentage < /b> with < /b> an absolute numbers of < /b> NK and < /b> B cells while reduced percentage < /b> with < /b> an absolute numbers of < /b> CD4 + lymphocytes in the peripheral ... the comparison of < /b> the absolute number < /b> of < /b> various peripheral blood lymphocyte subsets...

Ngày tải lên: 29/03/2014, 03:20

... reduced peripheral < /b> blood < /b> pre-switch IgD+CD27+ memory < /b> B cell population The frequencies of B cell subsets defined by the expression of IgD and CD27 in < /b> the peripheral < /b> blood < /b> of patients with longstanding ... synovium, they are also generated in < /b> increased numbers in < /b> patients with RA [19] As a result, post-switch me...

Ngày tải lên: 09/08/2014, 14:21

... rituximab therapy < /b> preceded by a decrease in CD19+CD27+ memory B cells in peripheral blood and bone marrow of RA patients We next examined the effect of rituximab therapy < /b> on memory (CD19+CD27+) B cells, ... CD19+CD27+ memory B cells Clinical response to rituximab correlates with depletion of CD19+CD27+ memory B cells in pe...

Ngày tải lên: 09/08/2014, 14:22

... Chapter Introduction 22 determines their effector functions The < /b> influence of < /b> cytokines in the < /b> differentiation of < /b> CD4+ T cell subsets and the < /b> effect of < /b> CD4+ T cell subsets with the < /b> emphasis on Tr1 ... When they encounter antigen, T cells are induced to proliferate and differentiate into cells capable of < /b> contributing to th...

Ngày tải lên: 14/09/2015, 08:27

... Figure Memory4< /b> B cells in peripheral blood Memory < /b> B cells in peripheral blood A) Percentages of < /b> memory < /b> B cells and class switched memory < /b> B cells (D) in peripheral blood of < /b> current smokers (closed symbols) ... Flow cytometry plots of < /b> B cells and memory < /b> B cells in peripheral blood Flow cytom...

Ngày tải lên: 12/08/2014, 14:20

... saline; PE: phycoerythrin; PE-Cy7: phycoerythrin-cyanin 7; PerCP: peridin chlorophyll protein; Siglec-2: Sialic acid-binding Ig-like lectin 2; SLE: systemic lupus erythematosus; SyK: spleen tyrosine ... Daridon et al.: Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus Arthritis Research...

Ngày tải lên: 12/08/2014, 15:21

... is that combining epratuzumab with rituximab, although not increasing the overall clinical response rate above what is seen with rituximab alone, may lead to a substantially higher number of complete ... in B cell lymphomas than the agent alone [10] Such approaches also create more clinical adverse reactions and would probably not be acceptable for use in SLE Another curious finding...

Ngày tải lên: 09/08/2014, 08:22

... underestimated by a single biopsy of the minor (labial) salivary glands In addition, minor (labial) salivary glands are the most frequently investigated but not the only tissue investigated for lymphocytic ... heavy-chain joining segment (JH6) [79], emphasizing the accumulation of memory B cells Thereby, enhanced influx and retention of particular polyclonal memory B cells into the...

Ngày tải lên: 09/08/2014, 10:20

... http://arthritis-research.com/content/11/5/247 [53,55] in myeloid cells suggests that BAFF may act as a kind of secondary cytokine translating mainly IFN and TNF effects An important immunoregulatory cytokine produced by B cells is IL-10, ... findings First, findings in both humans and mice have indicated an essential role for this cytokine in co-stimulating B cells to differentia...

Ngày tải lên: 09/08/2014, 14:22

... inflamed synovia and < /b> that blocking the effects of TNF decreases trafficking into and < /b> retention of B cells in the synovia, thereby increasing their proportion in the peripheral blood However, both ... of B and < /b> T cells and < /b> the establishment of the marginal zone [8] In general, TNF and < /b> soluble LTα are thought to have overlapping roles in this se...

Ngày tải lên: 09/08/2014, 14:22

... expression < /b> Finally, we examined the effects < /b> of < /b> the chemokines < /b> on < /b> the expression < /b> of < /b> the cell surface molecules ICOSL, BAFF-R and < /b> TACI by peripheral blood B cells of < /b> normal donors and < /b> sub- Page of < /b> 11 ... chemokine receptor < /b> expression < /b> by peripheral blood in both normal donors and < /b> subject...

Ngày tải lên: 09/08/2014, 14:22

... DNA-editing enzyme) in host target cells, which resulted in the accumulation of mutations in the tumour suppressor protein TP53 Type IV secretion in H pylori pathogenesis [22] Thus, the induction of ... to in uence the pathogenesis of H pylori There are two classical secreted virulence factors present in H pylori: the vacuolating cytotoxin (VacA) and...

Ngày tải lên: 14/02/2014, 19:20