The role of b cells in the pathogenesis of atherosclerosis 1

... Marginal Zone B cells 11 1. 4 Humoral Immunity in Atherosclerosis 12 1. 4 .1 Localization of < /b> B cells in Atherosclerosis 12 1. 4.2 Association of < /b> oxLDL-specific antibodies with Atherosclerosis ... further delineates the < /b> B1 population into B1 a (CD5+) and B1 b (CD5-) sub-populations B1 cell populations, unlike B2 cells, are not maintained thro...

Ngày tải lên: 10/09/2015, 09:23

... plasma cells in the < /b> bone marrow of < /b> apoE-/- mice Because we maintained the < /b> mice on BrdU in drinking water for one month, the < /b> result is also indicative that these plasma cells accumulated in the < /b> bone ... and/or increased bioavailability of < /b> 7α, 25 -OHC 3.4.1 Increased ch25h mRNA expression in the < /b> spleen of < /b> apoE-/- mice We exami...

Ngày tải lên: 10/09/2015, 09:24

... observed in the < /b> spleen of < /b> apoE-/- mice may be due to the < /b> inability of < /b> B cells to fall into the < /b> state of < /b> anergy However, it remains to be determined if APOE protein is crucial in maintaining the < /b> ... observed an increased frequency of < /b> oxLDL-specific oxLDL ASCs in the < /b> bone marrow in apoE-/- mice, indicative of < /b> thei...

Ngày tải lên: 10/09/2015, 09:24

... detected in this study The most notable findings were increased < /b> percentage < /b> with < /b> an absolute numbers of < /b> NK and < /b> B cells while reduced percentage < /b> with < /b> an absolute numbers of < /b> CD4 + lymphocytes in the peripheral ... the comparison of < /b> the absolute number < /b> of < /b> various peripheral blood lymphocyte subsets...

Ngày tải lên: 29/03/2014, 03:20

... staining for phenotypic markers in chondrocyte-like cells from human intervertebral discs Immunohistochemical staining for collagen phenotypic markers in chondrocyte-like cells from human intervertebral ... Suda A: Cathepsin G in degenerating and healthy discal tissue Clin Exp Rheumatol 1999, 17:197-204 Gruber HE, Hanley EN Jr: Analysis of aging and degeneration of the hu...

Ngày tải lên: 09/08/2014, 06:22

... the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence of interleukin-1β ... the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from cell death induced by pro-i...

Ngày tải lên: 09/08/2014, 07:20

... reduced peripheral < /b> blood < /b> pre-switch IgD+CD27+ memory < /b> B cell population The frequencies of B cell subsets defined by the expression of IgD and CD27 in < /b> the peripheral < /b> blood < /b> of patients with longstanding ... synovium, they are also generated in < /b> increased numbers in < /b> patients with RA [19] As a result, post-switch me...

Ngày tải lên: 09/08/2014, 14:21

... rituximab therapy < /b> preceded by a decrease in CD19+CD27+ memory B cells in peripheral blood and bone marrow of RA patients We next examined the effect of rituximab therapy < /b> on memory (CD19+CD27+) B cells, ... CD19+CD27+ memory B cells Clinical response to rituximab correlates with depletion of CD19+CD27+ memory B cells in pe...

Ngày tải lên: 09/08/2014, 14:22

... Chapter Introduction 22 determines their effector functions The < /b> influence of < /b> cytokines in the < /b> differentiation of < /b> CD4+ T cell subsets and the < /b> effect of < /b> CD4+ T cell subsets with the < /b> emphasis on Tr1 ... When they encounter antigen, T cells are induced to proliferate and differentiate into cells capable of < /b> contributing to th...

Ngày tải lên: 14/09/2015, 08:27

... demonstrate the presence of such opposite changes in the responsiveness of the airway and tissue compartments in the presence of oxygen toxicity Indeed, expression of the hyperoxia-induced changes in the ... in larger mammals [9,45] and in mice [46] Conclusion In summary, the results of the present study yield evidence of the involvement of ET-1...

Ngày tải lên: 12/08/2014, 16:20

... 11 6 11 9 4 .1 The role of Annexin- 1 in the regulation of inflammatory stress 11 9 response 4.2 Conclusion 14 4 4.3 Limitations of the study 14 5 4.4 Future work 14 6 Bibliography 14 8 Summary Annexin- 1 ... for investigation of the basis of the inflammatory stress response The aims of this study are thus, 1) To determine the role...

Ngày tải lên: 01/10/2015, 17:27

... function upstream of the effector caspases in apoptosis and are known as initiator caspases A phylogenetically distinct group of 13 caspases (caspase- 1, caspase- 4, caspase- 5, caspase- 11 and caspase- 12 ) ... caspase- 1 to an influenza A/ Puerto Rico/8/34 (H1N1) virus infection of RAW264.7 murine macrophages, in vitro To investigate the role of ca...

Ngày tải lên: 13/10/2015, 16:41

... because of the risk of EPS by antipsychotic drugs More detailed double-blind studies should be performed to clarify the role of sigma-1 receptors in the efficacy of fluvoxamine for psychotic ... involved in the active mechanisms of fluvoxamine [5] Based on all these findings, a hypothesis has been proposed that the sigma-1 receptors may be implicated in the eff...

Ngày tải lên: 08/08/2014, 23:21

... Figure Memory4< /b> B cells in peripheral blood Memory < /b> B cells in peripheral blood A) Percentages of < /b> memory < /b> B cells and class switched memory < /b> B cells (D) in peripheral blood of < /b> current smokers (closed symbols) ... Flow cytometry plots of < /b> B cells and memory < /b> B cells in peripheral blood Flow cytom...

Ngày tải lên: 12/08/2014, 14:20

... saline; PE: phycoerythrin; PE-Cy7: phycoerythrin-cyanin 7; PerCP: peridin chlorophyll protein; Siglec-2: Sialic acid-binding Ig-like lectin 2; SLE: systemic lupus erythematosus; SyK: spleen tyrosine ... Daridon et al.: Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus Arthritis Research...

Ngày tải lên: 12/08/2014, 15:21