chronic cardiotoxicity role of irp 1 and analysis of pathophysi

... copy of the written consent is available for review by the Editor-in-Chief of this journal Page of doi :10 .11 86 /17 52 -19 47-4 -14 8 Cite this article as: Akşahin et al.: Role of pathophysiology of patellofemoral ... comparison to open patellofemoral reconstruction Am J Sports Med 19 86, 14 (2) :12 1 -12 9 Miller PR, Klein RM, Teitge RA: Medial dislocation of the patella Skeletal Radiol 19 91, 20(6):429-4 31 Abhaykumar S, ... repair of the lateral retinaculum in 39 patients, and the remaining 26 were treated with the reconstruction of patellotibial ligament, of which 12 were by the help of iliotibial band and 14 were...

Ngày tải lên: 11/08/2014, 12:20

... infusion J Hepatol 2004;40: 219 -27 Int J Med Sci 2007, 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Seth D, Leo MA, McGuinness PH, et al Gene expression profiling of alcoholic liver disease in ... effect through induction of transcription factors (AP1, Elk1, Stat1, SRF and NFκB) and expression of apoptotic genes (Fas receptor, Fas ligand, FADD and caspase 8) [19 ] In addition, as confirmed ... COBRA1, ITGB4, STAU2, and HMGN3 with a SLR of 3.30, 2. 61, 1. 68 and 1. 52, respectively ANK3 was the only significantly down-regulated gene with a SLR of -5.02 Figure Hierarchical clustering analysis...

Ngày tải lên: 31/10/2012, 15:28

... B of the complex of HIV -1 protease with OE inhibitor 0.05 11 21 31 41 51 61 71 91 81 Residue number B factor 80 chain A 60 40 20 0 11 21 31 41 51 61 71 81 91 20 40 chain B Fig The complex of ... Inhibitor N1-CA1-C1-C2 CA1-C1-C2-N2 C1-C2-N2–CA2 C2-N2–CA2-C3 N1-CA1-C1 CA2-C3-N2 OE RE SE 11 2 56 60 -89 -17 5 -17 3 16 5 -14 8 -14 2 - 21 77 67 14 1 14 8 14 8 Fig 10 Stereoview of the position of inhibitor ... hydrogen bonds to the Asp29 S3¢ OE I50 A128 D129 D130 V132 I147 G148 RE SE – 14 – – 2 11 – – 31 18 23 OE R8 D129 G148 G149 F153 RE SE 1 13 – 1 11 – 22 20 13 ˚ and Asp30 with bond-length differences...

Ngày tải lên: 19/02/2014, 16:20

... Biochemistry 31, 19 74 19 79 19 Verbert A & Cacan R (19 99) [‘Glyco-deglyco’ processes during the biosynthesis of glycoproteins] J Soc Biol 19 3, 10 1 11 0 16 37 Role of N-glycosylation and N-glycan trimming of ... transporter type of mouse (mGAT1) The cDNAs of N-glycosylation mutants DGN (N176D, N181G), DDN (N176D, N181D) and DND (N176D, N184D) were constructed earlier [7] In each mutant, two of three FEBS ... GABA-uptake activity of NNN 16 31 Role of N-glycosylation and N-glycan trimming of GAT1 G Cai et al Fig Kinetic analysis of GABA-uptake by GFP-tagged GAT1 wild type (NNN) with and without dMM and N-glycosylation...

Ngày tải lên: 19/02/2014, 17:20

... sequence analysis revealed that the longest and intermediate bands were full-length CCN4 ⁄ WISP1 and WISP1v, respectively However, the shortest band was a novel variant of WISP1 (WISP1vx) not ... full-length CCN4 ⁄ WISP1 mRNA and WISP1v proteins As a result, positive signals representing fulllength CCN4 ⁄ WISP1 mRNA and WISP1v were Finally, the biological function of WISP1v and WISP1vx was evaluated ... effects of insulin-like growth factor -1 on breast epithelial cells Breast Cancer Res 7, 10 80 10 89 11 Luo X, Ding L & Chegini N (2006) CCNs, fibulin-1C and S100A4 expression in leiomyoma and myometrium:...

Ngày tải lên: 07/03/2014, 10:20

... Number of calculation 10 11 Structure 1E15 1GOIb 1E15c 1E15 1E6N 1E6N 1E6N 1E6N 1E6N 1E6N 1E6N Modelled adjustments D140N D142N, Asn142 ÔupÕc D 215 N Q144E Q144E, no substrate Q144E, Asp142 ÔdownÕ Q144E, ... nmolÆs )1 mg )1 % of WT Y10F S93A D140N D140A D142N D142A E144Q E144A Y 214 F D 215 N D 215 A WT 7.9 7.7 0 .17 0 .17 4.4 0 .13 0.028 0.0 016 1. 04 5.8 0.043 13 8 5.7 5.6 0 .12 0 .12 3.2 0.094 0.023 0.0 012 0.75 ... 8.2 11 .1 3.9 7 .1 1.2 5.4 7.9 12 .1 30.9 43.2 25.4 51. 6 4 .1 19 .1 20.2 33.2 ± ± ± ± ± ± ± ± pH 9.0 6.3 10 .8 5.0 14 .9 2.0 4.2 4.3 13 .5 45.6 ± 14 .4 –a 40.4 ± 7.6 ND 16 .6 ± 5.3 13 .4 ± 4.2 97 ± 14 .7...

Ngày tải lên: 07/03/2014, 14:20

... mechanisms of the Cyr 61/ CCN1 gene (Eur J Biochem 270) 3 413 Fig Induction of the Cyr 61/ CCN1 promoter upon stimulation by S1P and mapping of the responsive elements in the Cyr 61/ CCN1 promoter sequence ... phosphorylation of CREB and MSK1 was not depleted by Pd-98059 and SP-60 012 5 that inhibit ERK1/2 and JNK, respectively, consistent with the absence of effects of these signaling molecules on Cyr 61/ CCN1 gene ... CREB via MSK1 Role of RhoA and p38 kinase in the activation of Cyr 61/ CCN1 promoter Fig Immunoblot analyses of RhoA activation and p38 MAP kinase, CREB and MSK1 phosphorylation in S1P-stimulated...

Ngày tải lên: 08/03/2014, 08:20

... 17 9 18 0 18 1 18 2 18 2 18 3 18 4 18 6 18 8 19 0 19 1 19 3 19 4 19 5 19 6 19 7 19 8 19 9 200 2 01 204 206 208 209 210 212 213 215 215 217 218 9 .1 9.2 9.3 9.4 9.5 9.6 Alf, Bill, Charlie and the Bomb ... 14 3 14 3 14 4 14 5 14 7 14 7 14 9 15 1 15 2 15 2 15 6 15 7 16 0 16 2 16 3 16 6 16 7 16 7 17 1 17 2 17 2 vi CONTENTS Uncertainty and Risk 8 .1 Introduction 8.2 Consumption and uncertainty ... 14 8 14 9 15 0 15 1 15 3 15 5 15 7 15 9 16 0 16 1 LIST OF FIGURES xvii 7 .11 7 .12 7 .13 7 .14 7 .15 7 .16 7 .17 Excess demand for...

Ngày tải lên: 08/03/2014, 10:20

... 19 .85 1. 80 (1. 85 1. 80) P 212 1 21 a = 59.95 b = 65.32 c = 96.54 a = b = c = 90° 0.039 (0 .16 ) 14 .2 (4.7) 99.3 (94 .1) 3.2 (2.4) 35 563 0 .13 6 0 .16 3 0. 012 1. 25 0.08 3 214 24 289 17 19 24 75 38 .19 1. 70 (1. 79 1. 70) ... 3 211 38.23–2.00 (2 .11 –2.00) P 212 1 21 a = 58.57 b = 64.63 c = 94.48 a = b = c = 90° 0.069 (0.43) 17 .4 (3.7) 10 0.0 (10 0.0) 5.4 (5.3) 25 035 0 .15 4 0.200 0.020 1. 46 0 .11 3233 334 21 24 308 21 22 19 .85 1. 80 ... F229A F144Y ⁄ F258Y FEBS Journal 277 (2 010 ) 4549–45 61 ª 2 010 The Authors Journal compilation ª 2 010 FEBS KM (mgÆmL )1) kcat ⁄ KM (min )1 mLÆmg )1) 9400 5300 540 460 15 00 480 4.8 10 .6 20 .1 21. 1 13 .2...

Ngày tải lên: 15/03/2014, 23:20

... NanoLetters (2004) 433 [8] [9] [10 ] [11 ] [12 ] [13 ] [14 ] [15 ] [16 ] [17 ] [18 ] [19 ] [20] [ 21] [22] [23] [24] [25] 3037 J Kikkawa, Y Ohno, S Takeda, Appl Phys Lett 86 (2005) 12 310 9 X Zhao, C.M Wei, L Yang, ... and Si (1 1)-(2 Â 1) surfaces (see, A.A Stekolnikov, J Furthmüller, F Bechstedt, Phys Rev B 65 (2002) 11 5 318 ) J.E Northrup, Phys Rev B 44 (19 94) 419 D Hanemann, Phys Rev 12 1 (19 61) 10 93 K.C Pandey, ... {0 1} facets hydrogenated nanowire The density of isosurfaces is 1. 5 Â 10 À3 e/Å3 The wave functions of p- and p*-like bands on Si (1 1)-(2 Â 1) surfaces are also shown on the inset of (a) and...

Ngày tải lên: 16/03/2014, 15:37

... & Van Leuven, F (19 98) Ó FEBS 2004 4494 M Pastorcic and H K Das (Eur J Biochem 2 71) 10 11 12 13 14 15 16 17 18 19 20 21 Deficiency of presenilin -1 inhibits the normal cleavage of amyloid precursor ... and SH-SY5Y cells Each construct was tested in three transfections, each with n ¼ SK-N-SH cells SH-SY5Y cells Promoter fragment wt m wt )11 9/ +17 8 )11 9/ +14 3 )22/ +17 8 )22/+4 10 0 73 91 23 21 ± 10 ... Sp1 motifs on PS1 promoter activity The positions of Ets (d) and Sp1 (h) motifs in the )11 9/ +17 8 region of the PS1 promoter are indicated The positions relative to the +1 site of point mutations...

Ngày tải lên: 16/03/2014, 18:20

... DEAE10 85.3 87.4 71. 9 36.5 3696 516 76 17 .4 0.023 0 .17 0.95 2 .10 41 91 100 10 2 84 43 Conditions of Qor synthesis in wild-type P putida 86, P putida 86 -1 Dqor pUF1 and P putida 86 pJB653 Qor of ... 0.0 01 0.0 01 < 0.0 01 0 .11 0 .10 0. 21 0 .18 –a Qor protein from P putida 86 -1 Dqor pUF1 Immunodetection of the subunits of Qor in Western blots confirmed that the deletion mutant P putida 86 -1 Dqor ... Chemical Analysis Laboratory of the University of Georgia (Athens, GA, USA) The protein samples used for metal analyses showed specific activities of 15 .5 UÆmg )1, 1. 8– 2.3 UÆmg )1 and 18 UÆmg )1 for...

Ngày tải lên: 17/03/2014, 10:20

... 0 .10 M) L-Ascorbate Guaiacol Enzyme kcat (s )1) Km (mM) kcat/Km (mM )1 s )1) kcat (s )1) Km (mM) kcat/Km (mM )1 s )1) rAPX H42E 248 ± 28 3.9 ± 0.2 0. 41 ± 0.04 0 .17 ± 0.09 605 22.9 66 ± 1. 5 ± 0 .1 12.3 ... (data not shown and [ 21, 22]) and pAPX [17 ], a linear dependence on [H2O2] is observed; in this work, a second-order rate constant of (6 .1 ± 0 .1) · 10 7 M )1 s )1 was derived for reaction of rAPX with ... microscopic second-order (ka) and first-order (kb) rate constants for this step (Kd ¼ kb/ ka)]: values for ka of 84 ± M )1 s )1 and 1. 1 ± 0.2 · 10 5 M )1 s )1 were obtained for H42A and H42E, respectively...

Ngày tải lên: 18/03/2014, 01:20

... 4.5 0 .1 0 .1 0 .1 0 .1 0 .1 7.4 7.7 7.5 9.0 6.9 DpKES1 0 .1 0 .1 0 .1 0 .1 0 .1 DpKES2 +0.8 +0.6 +0.7 )0.3 +0.3 +0 .1 +1. 6 )0.5 mutants The reaction order relative to phenylglyoxal (1. 7) indicates ... Wild-type R97M Y331F E187D 2.3 1. 9 2.0 4.4 kcat/Km (s )1 mM )1) kcat (s )1) Km (mM) 0 .1 0.3 0.5 0 .1 1.73 0.0030 0.0070 0.0 014 7 Fig Eect of pH on the activity of native (j) and recombinant ... R97K, Y331F and E187D) were expressed as recombinant proteins in Escherichia coli The general shape and volume of residues 97 and 3 31 side chains are conserved in the mutants R97M and Y331F, but...

Ngày tải lên: 23/03/2014, 15:21

... 2.5 9.6 3.0 ã ã ã ã 10 )5 10 )4 10 )4 10 )3 3.3 3.4 1. 1 4.4 ã ã ã ã 10 7 10 5 10 6 10 5 v 2.9 3 .1 1.7 3 .1 ã ã ã ã 10 )4 10 )4 10 )3 10 )4 mutant (Fig 4, insets) Notably, in 7.9 m GdmCl and 40 mm CaCl2, the ... m )1, 8.6 m )1, 8.4 m )1 and 9.4 m )1 for the wild-type and D287A, E53A and the double mutant, respectively In 7.9 m GdmCl, the acrylamide quenching constants were 13 .0 m )1, 9.9 m )1, 11 .5 m )1 and 10 .3 ... (kJặmol )1) mg DDGH2O )1 )1 (kJặmol ặM ) (kJặmol )1) Wild-type D287A E53A E53A D287A 6.7 6.2 6.0 6.2 9.2 5.9 5.6 5.3 0 .13 0 .15 0 .12 0 .15 61. 5 36.5 33.9 33 .1 1. 23 0. 91 0.68 0.83 0 .18 0 .15 ...

Ngày tải lên: 30/03/2014, 04:20

... Ó FEBS 2004 Role of ERK1/2 in neuronal survival (Eur J Biochem 2 71) 20 51 overexpression of mutated elements of the pathway, use of pharmacological inhibitors and genetic ablation in ... Shapiro, P.S & Ahn, N.G (19 98) Feedback regulation of Raf -1 and mitogen-activated protein kinase (MAP) kinase kinases and by MAP kinase phosphatase -1 (MKP -1) J Biol Chem 273, 17 88 17 93 Mody, N., Leitch, ... treatment of tumors of the central nervous system: pharmacological considerations and results of early studies Int J Radiat Oncol Biol Phys 28, 5 31 542 18 Anderson, C.N.G & Tolkovsky, A.M (19 99) A role...

Ngày tải lên: 30/03/2014, 14:20

... Pr[S1 = j 1] = Pr[S1 = j ; y1 ] 17 = f (S1 = 1; y1 j f (y1 j ) 0) = f (yt j S1 = 1; P t = f t ; yt g to obtain Pr[S2 = j ], etc =1j f (y1 j S1 = j; ) Pr[S1 Then Pr[S1 = j 1] j=0 where, ) Pr[S1 ... First, Beveridge and Nelson (19 81) , Nelson and Ploser (19 82), and Cambell and Mankiw (19 87) assume the stationarity of the rst log difference of the real GDP and emphasize on the usage of ARIMA models ... need to obtain Pr[S1 = j 1] 1] (2 .11 ) 0] 0] (2 .12 ) and Pr[S2 = j and Pr[S1 = j ] ], For that purpose we deploy the following procedire: Step Once yt is observed at the end of time t, the probability...

Ngày tải lên: 03/06/2014, 02:10

... hsa-miR -10 6b hsa-miR-20b 4 .11 2.63 2.47 2.43 2. 21 1.93 1. 92 1. 86 1. 86 1. 81 1.76 1. 73 1. 70 1. 66 1. 63 1. 6 1. 48 1. 43 1. 42 1. 33 1. 31 hsa-miR -13 3a hsa-miR-504 hsa-mir-565 hsa-miR -1 hsa-miR- 216 hsa-miR-485-5p ... 89,954 13 1,558 ± 35,298 21. 0 ± 13 .0 61. 1 ± 7.5 473 .1 ± 239 11 .1 ± 6.5 10 ,467,524 ± 7,793,493 1, 672 ± 854 93.5 ± 27.8 1, 1 81 ± 10 91 8,4 21 ± 2,684 930, 916 ± 650,0 21 527,593 ± 45 ,14 17 338 ± 330 10 9.0 ... CD15 CD16 CD18 CD177 18 2 ± 51 480 ± 284 2,946 ± 1, 345 4 51 ± 300 625 ± 383 18 7 ± 10 7 374 ± 236 2,580 ± 1, 138† 250 ± 81* 575 ± 267† 17 1 ± 10 0 373 ± 265 2, 410 ± 1, 430† 267 ± 10 0 587 ± 2 51 * p < 0.05...

Ngày tải lên: 18/06/2014, 15:20

... 0.48 0. 31 Sinsi -11 .16 0. 01 0.04 SE 0. 31 AP .18 /18 2, 18 3 AP.2/221A AP.28/282, 284 AP.33/3 31, 334 AP.4/452, 454 AP.5/ 512 , 514 AP.6/639 AP .10 /10 11, 10 14 A score of -6.96 was used as a cut off for ... 210 1 (B-X4/R5) 30 41 (C-R5) 54 41 (C-X4) MAGI-CXCR4 10 000 5000 No of blue cells 21 23 9 13 23 1 11 16 - 10 000 Phenotype from MT-2 No of blue cells 99 92 18 12 30 31 65 26 33 19 10 34 - 10 23 21 ... HIV -1 subtype C chimeras in U373-MAGI-CCR5 and U373-MAGI-CXCR4 cell lines MAGI-CCR5 Infection counts → 5000 CHIMERA_ 17 1 17 3 18 2 18 3 221A 282 284 3 31 334 452 512 514 639 10 11 1 014 2099 (B-R5) 210 1...

Ngày tải lên: 18/06/2014, 18:20

... 2009;Orlando, FL J Clin Oncol 2 010 , 27 :15 s, [abstract 10 555] doi :10 .11 86 /14 79-5876-9-75 Cite this article as: Maleddu et al.: The role of mutational analysis of KIT and PDGFRA in gastrointestinal ... deletions of codons 557 and/ or 558 of KIT exon 11 (critical mutations), non-deletion-type mutations of KIT exon 11 (NDTM) which included missense mutations and insertions, and other deletions of KIT ... mutations and KIT exon 11 deletions involving codons 557 and/ or 558 correlate with a higher rate of recurrence, whereas patients with point of mutation or insertion of KIT exon 11 had a lower rate of...

Ngày tải lên: 18/06/2014, 19:20