AP 2 regulates estrogen receptor mediated long range chromatin interactions and gene transcription
AP 2 regulates estrogen receptor mediated long range chromatin interactions and gene transcription
... Yong EL, Sung WK, Cheung E (20 11) AP- 2gamma regulates oestrogen receptor- mediated long- range chromatin interaction and gene transcription The EMBO journal 30: 25 69 -25 81 Chng KR, Chang CW, Tan ... association of AP- 2 and FoxA1 with ERα -mediated long- range chromatin interactions 107 CHAPTER 4.1 4 .2 4.3 4.4 DISCUSSIONS 109 Exploring potential determinant...
Ngày tải lên: 09/09/2015, 10:20
Estrogen receptor a mediated long rang chromatin interactions at the ret gene locus in breast cancer
... ATCAAACTGGAGGGAGCAGA B TCAGACAGTGCCAGTGGAAG E GCCAGTGGAAGTGTAAGTTGG B TCGGGACACAGCATCATAA F GACACTGACAGGATTTACCATACTGTTGG B TCGGGACACAGCATCATAA G GGTCAAGTGTTCCCGTGATCCTACTG B TCGGGACACAGCATCATAA H CACAGGGAAATGCAGCACAGCTAG ... 23 AB BC BD BE BF BG BH BI BJ BK IJ A CATGGGAGAAAGATGTAGTCTGGGAGAC B CTCTTTCGGGACACAGCATCATAATC B CTCTTTCGGGACACAGCATCATAATC C GAAAGGACAGAGAAGGTGCCAGTTG B TTCGGGACACAG...
Ngày tải lên: 05/10/2015, 21:29
Tài liệu Báo cáo khoa học: Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity pdf
... chloroquine and monensin interfered with the ATP-dependent intraendosomal degradation of internalized radioactive CT [6] Recently, we have identified an endosomal aspartic acid protease, cathepsin D, ... action of cholera toxin and cathepsin D T El Hage et al min) increased two-fold in endosomes isolated from CT-injected rats (closed squares), but this was not observed f...
Ngày tải lên: 19/02/2014, 02:20
Báo cáo y học: "Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes." potx
... is defined physically by the extent of long-range regulatory elements around its target gene Therefore, the combined synteny of HCNEs and the intertwined genes defines a minimal span of the GRB ... by a synteny- maintaining array of HCNEs [25], many of which were shown to act as the gene's regulatory inputs [6,26], often intertwined with other, unrelated (bystan...
Ngày tải lên: 09/08/2014, 20:20
THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 2
... ROS/RNS 10 5 contributes approximately 20 % of the overall down- regulation of NHE1 transcription by 5M of 15 d-PGJ2 10 6 Figure 11 : ROS/RNS contributes to down- regulation of NHE1 (A) MCF-7 (3 X105 cells/6-well ... (Figure 11 C) In contrast, 15 d-PGJ2 caused 61% reduction in NHE1 mRNA in the absence of NAC We reasoned that this difference in magnitude of dow...
Ngày tải lên: 09/09/2015, 10:19
Nghiên cứu khái quát về hệ thống bơm chất lỏng tăng áp 2 cấp. Thiết kế giám sát tự động tự động cho trạm có nhiều bơm tăng áp
... Thiết kế giám sát tự động cho trạm bơm tăng áp 17 2. 1 Các phần tử trạm bơm 17 2. 2 Xây dựng mach động lực 18 2. 3 Xây dựng mạch giám sát hệ thống 20 Chương Xây dưng chương trình giám sát 22 3.1 Xây ... Những hệ thống bơm đặc biệt bơm dầu, hoá chất thiết phải có nhiều vị trí dừng có cố, hoả hoạn… 1 .2 Hệ thống bơm chất l...
Ngày tải lên: 05/01/2014, 14:04
Báo cáo khoa học: Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2a receptor mediated activation of MEK⁄ ERK-CREB cascade doc
... CREB Adipogenesis COX-2 PGF2α AKR1B3 PGE2 Fig Schematic representation of a novel suppression mechanism operating in the early phase of adipogenesis through a positive feedback loop by enhancement ... molecular mechanism of this Fluprostenol -mediated increase in PGF2a production in adipocytes, at first we investigated the expression of genes invo...
Ngày tải lên: 28/03/2014, 22:20
Nghiên cứu khái quát về hệ thống bơm chất lỏng tăng áp 2 cấp thiết kế điều khiển tự động cho trạm có nhiều bơm tăng áp 2 cấp
... tự động bơm trạm bơm - Thiết kế bảo vệ động truyền động, bảo vệ bơm làm việc bền vững hệ thống - Hệ thống đảm bảo báo động, tín hiệu hoá, tự động dừng tự động khởi động có yêu cầu - Những hệ ... h , cấp nước hệ thống bơm, từ cấp cho hộ phía sau sơ đồ tổng quan hệ thống bơm bồn hở 10 10 2 P1 bom m?i Ð3 Ð1 1 .2. 2 Yêu cầu công nghệ...
Ngày tải lên: 06/05/2014, 21:17
Báo cáo y học: "Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor " pot
... main finding is that estrogen -mediated suppression of inflammation as seen in the TT-DTH response and in experimental arthritis is mediated via ERα but not ERβ The mechanisms underlying estrogen ... reduced inflammatory cytokine production in the synovium It remains to be established whether the data in the preclinical models can be translated to...
Ngày tải lên: 12/08/2014, 14:21
THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 1
... 1. 1.5 Ligands and physiological functions of PPARα and PPARδ 1. 1.6 Ligands of PPARγ 1. 1.7 PPARγ and adipogenesis 10 1. 1.8 PPARγ and insulin sensitization 12 1. 1.9 ... PPARs and cancer 13 1. 1 .10 PPARγ and breast cancer 15 1. 2 ESTROGEN RECEPTORS (ERS) 18 1. 2 .1 Identification and structures of ERs 18 1. 2.2 Mechanism of action of ... PPARγ -...
Ngày tải lên: 09/09/2015, 10:19
THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 4
... EFFECT OF PPARγ ON NHE1 Given that the presence of estrogen blocked the down- regulation of NHE1 expression induced by PPARγ lgiands, we next investigated the role of estrogen receptor in PPARγ -mediated ... protein and mRNA is mediated by estrogen recptor alpha 13 1 Figure 19 : Re-expression of ERα blocks PPARγ -mediated down- regulation of NHE1 ex...
Ngày tải lên: 09/09/2015, 10:19
THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 6
... basis and biological significance." Oncogene 25( 51) : 67 31- 67 48 Bunone, G., P A Briand, et al (19 96) "Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct ... hepatotoxicity: another lesson from troglitazone." Diabetologia 51( 11) : 210 8 211 6 Jurka, J and A Milosavljevic (19 91) "Reconstruction and analysis of human...
Ngày tải lên: 09/09/2015, 10:19
THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 3
... to 15 d-PGJ2, while 15 d-PGJ2 resulted in the maximal reduction in the number of colonies formed by MDA-MB-2 31 cells expressing the highest level of PPARγ receptor 11 2 Figure 14 : PPARγ agonists ... cells and only a 36 % down- regulation in T47D cells (Figure 14 D) Interesetingly, the extent of inhibition on cologenic ability of different breast cancer cell...
Ngày tải lên: 09/09/2015, 10:19
THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 5
... PPARγ -mediated NHE1 down- regulation From the results shown above, we concluded further that the DNA binding ability of ERα is involved in inhibiting PPARγ -mediated NHE1 repression 15 1 15 2 Figure ... 30% reduction in NHE1 mRNA in ER positive MDA-MB-2 31 cells It is interesting that in the absence of fulvestrant, 1 M of 15 d-PGJ2 brought down NHE1 mRNA to 50 % of...
Ngày tải lên: 09/09/2015, 10:19
Characterization of zebrafish vitellogenin gene family for potential development of receptor mediated gene transfer method 2
... full-length cDNA sequences of vtg1-7 A8** A17 A 22 A30 A67 A80 A87 A119 A 126 A139 A183 A186 A1 92 A193 A 220 A 227 A248 A250 A2 52 A253 A256 A257 A259 A269 A2 72 A290 A295 A296 A300 A306 A3 42 A349 A368 A371 ... (24 0) 44% (28 8) 43% (23 5) 47% (24 7) 40% ( 325 ) 49% (22 2) 39% (316) 48% (26 5) 40% (20 8) 47% (25 9) 43% (24 9) 46% ( 328 ) 52% (20 0) 43% (20 5) 43% (21 8) 46% (25 2) 43...
Ngày tải lên: 16/09/2015, 17:13