The androgen receptor centric transcriptional network in prostate cancer

... DNA binding domain (DBD) where four-cysteine zinc-binding domains are located, a ligand binding domain (LBD) harboring another transcriptional activation unit AF-2 and a hinge region connecting ... 1.7.2 The Androgen Response Elements and other Motifs in ARBS Like other DNA binding transcription factors, the AR DNA binding domain is mainly responsible for determining its DNA binding...

Ngày tải lên: 09/09/2015, 10:14

... subdomain AR3)13 in N/C interaction and the role of individual amino acid residues in and flanking the 23 FQNLF2 7motif in AR16)36 in N/C interaction Yeast protein interaction assays indicated that AR3)13 ... E., Brinkmann, A.O & Trapman, J (1997) Functional in vivo interaction between the amino- terminal, transactivation domain and the ligand bind...

Ngày tải lên: 17/03/2014, 10:20

... nuclear receptors The androgen receptor The polymorphic region of CAG repeats in the androgen receptor gene CHAPTER 1: CAG REPEAT POLYMORPHISM IN THE 17 ANDROGEN RECEPTOR GENE AND MALE INFERTILITY INTRODUCTION ... TRINUCLEOTIDE (CAG) REPEAT POLYMORPHISMS OF THE ANDROGEN RECEPTOR GENE IN HUMAN DISEASE AMPARO MIFSUD GINER (B Science (Hon...

Ngày tải lên: 11/09/2015, 09:05

... conceivable that the < /b> in < /b> vitro binding conditions are not suitable for simultaneous binding of the < /b> two proteins to the < /b> GC1 ⁄ CA2 SOX10 and Sp1 bind to the < /b> EDNRB promoter in < /b> vivo To investigate whether ... end-labeled with < /b> [c-32P] ATP and used as probes The < /b> SOX10-containing lysates were preincubated for 30 on ice with < /b> or without a c...

Ngày tải lên: 16/03/2014, 13:20

... is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... limited number of cytokines that inhibit the adhesiveness, growth and migration of cancer cells The most intriguing finding of the present study was that the functio...

Ngày tải lên: 18/06/2014, 19:20

... substantial loss in nicotinic receptors in cortex and striatum According to the growing amount of findings, accumulation of amyloid plaques which are the baseline indicator in the brain for AD is interfered ... in response to acute nicotine exposure It furthermore suggests the strong synchronization of hippocampal neural network in the mid phase (ga...

Ngày tải lên: 19/06/2014, 08:20

... is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... limited number of cytokines that inhibit the adhesiveness, growth and migration of cancer cells The most intriguing finding of the present study was that the functio...

Ngày tải lên: 20/06/2014, 03:20

... analyzed whether treatment with the Akt-inhibitor ErPC3 would increase the short- time antineoplastic effects of ionizing radiation in the prostate cancer cell lines Combined treatment with ErPC3 and ... reduced the number of viable LNCaP, PC3 and DU145 cells as determined by the WST-1 test In PC3 and DU145 cells the antineoplastic effects of th...

Ngày tải lên: 09/08/2014, 09:20

... Artificial neural networks (ANNs) are attractive analytical tools in medicine due to their ability to learn from historical examples, analyze non-linear data and being able to generalize a model to independent ... in a preclinical study in prostate cancer xenografts, and suggest that the combination of functional MRI parameters, in addition to standard clin...

Ngày tải lên: 09/08/2014, 09:20

... article as: Vranova et al.: The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques Radiation ... and GU toxicity observed in patients during their last inspection are shown In the cohort of patients included in the WP group, pretreatm...

Ngày tải lên: 09/08/2014, 09:20

... http://www.ro-journal.com/content/6/1/123 Page of 11 Figure Example of the contouring of the penile bulb, based on the guidelines suggested by the steering committee The projection of the PB contour on the more ... imaging technique for most radiotherapy Institutes where access to MRI for planning is still lacking Although the well documented limitation of CT i...

Ngày tải lên: 09/08/2014, 09:21

... during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression of cell cycle controlling ... with genistein 10 μM and irradiation with Gy together, the effects of genistein on survival in these cell lines seem to be independent of ER- and p...

Ngày tải lên: 09/08/2014, 09:22

... To our Figure Inhibition of trypsin-induced cyclooxidase-2 (COX-2) expression by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in human synoviosarcoma cells Human synoviosarcoma ... Inhibition of trypsin-induced nuclear factor (NF)-B activation by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in synovial cells Human primary synovial...

Ngày tải lên: 10/08/2014, 05:21

... virus- receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody Retrovirology 2010, 7:38 Page 13 of 13 ... the virus- receptor interaction may not simply be a modulation of binding affinity, rather it could represent a shift in the way the Env and rece...

Ngày tải lên: 12/08/2014, 23:23

... association of XMRV infection with higher grade tumors [7] Contrary to the initial study, Singh’s study found viral antigen-positive cells primarily in malignant prostatic epithelium, independently of the ... out of 201 non-PCa (Figure 4D) sera marginally reduced the XMRV infectivity (over 80% block of XMRV infectivity at a 10-fold dilution) However, by Western blot prob...

Ngày tải lên: 13/08/2014, 01:20