the function of yy1 and its oncogenic role in prostate cancer

... partners and their role in the developing cytoskeleton The work in this thesis focuses on the developing fly eye, the targeting of axons from the eye to the brain and the anchoring of posterior ... critical roles in regulating the guidance of both crossing and non-crossing axons at the ventral midline of the developing vertebrate spinal cord and the Drosophila ventral nerve cord For example, these ... This thesis looks at the function of bif and its interacting partners, Protein phosphatase and Homer, in several different developmental contexts and focuses on Bif function in the eye, the larval...

Ngày tải lên: 12/09/2015, 09:42

... solid line), in the presence of 100 lM neurotoxin ( , dotted line), in the presence of 200 lM neurotoxin ( , dotted line) and in the presence of neurotoxin and 50 lM dopamine (h, dashed line) • 1692 ... (C), in the presence of 100 lM MPP+ (D), in the presence of 200 lM MPP+ (E), in the presence of 100 lM MPTP and 50 lM dopamine (F), in the presence of 200 lM MPTP and 50 lM dopamine (G), in the ... shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 lm dopamine on the aggregation process Dopamine delayed the lag phase of aggregation marginally...

Ngày tải lên: 14/02/2014, 19:20

... SUMMARY AND CONCLUSIONS The banking industry is undergoing three major changes the consolidation of the industry, the spread of Internet banking, and the increased freedom to combine banking with other ... obstacle in continuing to fill this role the increased difficulty of obtaining funds I MAJOR CHANGES IN THE BANKING SYSTEM While always in a state of flux, the nation’s banking system is now undergoing ... Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle,” Journal of Banking and Finance, August, pp 657-59 Board of Governors 1997 “Report to the...

Ngày tải lên: 16/02/2014, 11:20

... aluminium and steel which in uence the welding behaviour: • The difference in melting points of the two metals and their oxides The oxides of iron all melt close to or below the melting point of ... Increasing the arc current increases the temperature of the weld pool and thereby increases the rate of absorption of hydrogen in the molten metal Conversely, in the flat welding position increasing the ... between the grains there is a mismatch, a loss of order, in the orientation of these arrays Both the grain boundaries and the size of the grains can have a marked effect on the properties of the...

Ngày tải lên: 12/03/2014, 17:32

... experiment, the collection, analysis and interpretation of data, the drafting the manuscript and acquisition of funding RWC contributes to the analysis and interpretation of data, drafting the manuscript ... manuscript and acquisition of funding AO contributes to the analysis and interpretation of data, drafting the manuscript and acquisition of funding All authors have read and approved the final manuscript ... pressure of the compartments needed to stop further water transmission across the membrane At the beginning of each experiment, the fluid heights indicating the pressure in both compartments, i.e either...

Ngày tải lên: 20/06/2014, 00:20

... doi:10.1038/cddis.2011.12 The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling, Hui-Min Lin, Kuan-Boone Tan and Gigi N.C Chiu International ... presenting author) Podium Presentation The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling*, Hui-Min Lin, Kuan-Boone Tan and ... a protein kinase C (PKC) and sphingosine kinase (SK) inhibitor, and is currently evaluated in Phase I clinical trials Yet, the underlying mechanisms of its action remain largely unknown The research...

Ngày tải lên: 11/09/2015, 10:02

... depicting various motifs of the CK2 proteins Within the α subunit of human CK2, the domain in grey includes the invariant Lys-68 which is involved in ATP binding, followed by a cluster of basic ... proximal to the N-terminal boundary of the Cdk5-binding and activating domain in p35, and contains an amphipathic α-helix (Chin et al., 1999) Further evidence from the interaction studies indicates ... advantage of this method is the ability to isolate protein complexes and interacting proteins in their native states It is particularly useful in identifying indirectly interacting proteins, 38 since...

Ngày tải lên: 16/09/2015, 17:10

... domain and ∆BAR domain in vitro In addition, the random coil domain does not affect the bridging of SH3 domain to PRD in vitro Therefore, the random coil domain or Ca2+ is not involved in interactions ... detail study on the role of this domain to the functions of the SH3 & BAR domains The praline-rich random coil domain exists in all the members of the Endophilin family but its amino acid sequence ... An interesting hypothesis was proposed suggesting that the SH3 domain of endophilin might bind to its own proline rich domain located between the SH3 domain and BAR domain in the presence of...

Ngày tải lên: 03/10/2015, 20:32

... broaden the scientific underpinnings of the PBT analysis, the difficulty of prescribing a meaningful way to quantitatively weight the various PBT parameters and to integrate them into a single numerical ... distribution This book reports the findings of a workshop organized around the constructs of PBT for purposes of examining strengths and weakness in each of these criteria and identifying alternatives or ... reviewing the scientific underpinnings of the use of persistence in hazard evaluation and of persistence measures as applied to metals, including the potential to use bioavailability measures in...

Ngày tải lên: 16/03/2014, 11:45

... deceleration during the second half of the move, with concomitant high jerk at the beginning, middle and end of the perturbation [13,14] While standing barefoot and blindfolded on the SLIPFALLS ... aided in data analysis and drafting Page of 10 and revising the manuscript SM performed data analysis and aided in drafting and revising the manuscript CMS performed data acquisition, aided in data ... threshold over the course of the 30 trials in two of the three distances (1 mm, mm, and 16 mm) and were not used in the analysis There are a few possible explanations for this A small number of these...

Ngày tải lên: 19/06/2014, 08:20

... of C with Î U, F(U)bounded and F : U → C a condensing mapping Then, either F has a fixed point in U or there is a point u Î ∂U and l Î (0,1) with u = lF(u); here U and ∂U denote the closure of ... contributions The work presented here was carried out in collaboration between all authors SP and AA defined the research theme SP designed theorems and methods of proof and interpreted the results ... as: Arunchai and Plubtieng: On the Krasnoselskii-type fixed point theorems for the sum of continuous and asymptotically nonexpansive mappings in Banach spaces Journal of Inequalities and Applications...

Ngày tải lên: 21/06/2014, 01:20

... in PC3 and LNCaP prostate cancer cells Moreover, we compared the effects of ErPC3 to the effects of the PI3K inhibitor LY294002 LY294002 inhibits the upstream kinase PI3K thereby preventing the ... based on their ability to induce apoptosis in tumor cells and their ability to increase cytotoxic efficacy of chemotherapy and radiotherapy in preclinical investigations [10-12] Induction of apoptosis ... differences in the basal levels or treatmentinduced changes in the expression of several proteins of the Bcl-2 family known to function as key regulators of the mitochondrial homeostasis and intrinsic...

Ngày tải lên: 09/08/2014, 09:20

... reviewing the scientific underpinnings of the use of persistence in hazard evaluation and of persistence measures as applied to metals, including the potential to use bioavailability measures in ... explanation without intent to infringe Library of Congress Cataloging -in- Publication Data Adams, William J., 1946Assessing the hazard of metals and inorganic metal substances in aquatic and terrestrial ... and regulation of natural resources, education, research and development, and manufacturing and distribution Specific goals of the society are: • Promote research, education, and training in the...

Ngày tải lên: 12/08/2014, 04:22

... membranes of the epithelial cells by endocytosis and further metabolic processing The intestine is also the site of small organic molecule uptake Metals may bind to these molecules and inadvertently ... considering the organism as consisting of different kinetic compartments These compartments may or may not reflect physiological units depending on the degree of detail in the model In its most ... and the United States The biodynamic model requires concentrations of metals within the food of M edulis, and these were estimated using the distribution coefficient, KD (l/kg) and the following...

Ngày tải lên: 12/08/2014, 04:22

... providing input to the UWM, and (3) providing an interim solution to the use of aquatic toxicity data in metal categorization, independent of and in advance of the UWM 5.2 DATA ACCEPTABILITY The ... species, and (2) the toxicity of these species, rather than (3) the toxicity of the original metal substance There is no doubt that characteristics such as solubility and transformation (and their kinetics), ... the speciation component of the BLM The current use of WHAM (Tipping 1994) in the BLM construct, however, does not preclude the future use of other types of speciation models, such as WHAM (introduced...

Ngày tải lên: 12/08/2014, 04:22

... affecting the mass balance of metals in soils are the anthropogenic and natural inputs and the outputs via leaching to groundwater and removal through surface erosion and crop harvesting The elimination ... changes in climate and land use 6.3.3 AGING OF METALS IN SOIL Persistence of total metals in soil and persistence of metal bioavailability and solubility are not the same In the latter case, the ... determined by averaging the ranks of birds and mammals Rank determined by reassigning the wildlife ranks to and then averaging ranks of wildlife, plants, and invertebrates b (Section 6.4.2) or using...

Ngày tải lên: 12/08/2014, 04:22

... parallels the more potent NRTIs being administrated and possibly the protective role of the other drugs in the regimen (e.g., boosted protease inhibitors) The rising prescriptions of NNRTIs during the ... assistance of the virologist through the interpretation of the genotypic resistance information In particular, the decline in resistance can be partially explained by the fact that in the early years of ... discussed in the introduction, most publications state that the prevalence of resistance is increasing over time, resulting in the continued focus of drug designers on the activity of drugs against...

Ngày tải lên: 13/08/2014, 06:20

... results proved the change of brain resistance and the improvement of brain compliance (by the increasing of velocity) The PI decreased collerately with the change of intracranial pressure The result ... hematoma: The formation and the size of the hematoma will define the severity of increasing ICP The clinical manifestation includes: subarachnoid hemorrhage, intracranial hemorrhage, intra-ventricular ... surrounding the lesion, or the whole brain, cause diffuses brain edema Brain edema and brain vessel vasodilation can worsening the primary lesion Brain edema: Brain edema is defined as increase of...

Ngày tải lên: 04/10/2014, 12:44

... documents of the remote sensing image analysis saw that in the mountainous areas in research had 420 points of the moving rock and soil on slope and sloping roof In particular, sloping roof on the ... according to the moving type (mechanisms) The laws of distribution moving points of rock and soil by type (mechanisms) of moving on slope and sloping roof in research area as following: Dominant landslide ... in the entire of research space 4.4 Mapping the zoning risk of lanslide on slope in research area Zoning and prediction map of the risk of landslide was built on the principle of overlapping integrated...

Ngày tải lên: 17/10/2014, 11:58

Ngày tải lên: 24/11/2014, 02:22