The regulation of nuclear factor erythroid derived 2 related factor 2 (NRF2) in the phase 2 response 2
The regulation of nuclear factor erythroid derived 2 related factor 2 (NRF2) in the phase 2 response 2
... to the presence of a conserved 43-amino acid Cap’n’Collar (CnC) domain at the Nterminus of the Nrf2 DNA binding domain (Figure 1.1) The name Nuclear factor erythroid- 2 (NF-E2) -related factor 2 ... factor erythroid- 2 NF- κB Nuclear Factor- kappaB Nrf2 Nuclear factor erythroid- 2 (NF-E2) -related factor Nqo1 NAD(P)H:quinine oxidoreductase xii PKC...
Ngày tải lên: 09/09/2015, 08:16
Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles pot
... is in uenced by the fatty acid composition of the particles Phosphorylation of p65–NF-jB plays a critical role in regulating its transcriptional activity To further investigate the effects of the ... accompanied by modulation of in ammatory processes in macrophages, and that the extent of the inhibitory action on the NF-jB pathway depends upon t...
Ngày tải lên: 23/03/2014, 04:20
Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... CGGCCCGGGAACTGATTAAGAGTCTGTCG GAGCCATGGAACAACGGAAAAGCGAGAAAC CGGCCCGGGAACTGATTAAGAGTCTGTCG CACCATGATGGTACTGAGAG GAATGTAGCTATGCGAGAGTTC CACCATGGCCGAGTTCAGAAATGGAGAAG GAATGTAGCTATGCGAGAGTTC CACCATGCTGAAGACACTTCCGGCCAACAG ... CACCATGCTGAAGACACTTCCGGCCAACAG GAATGTAGCTATGCGAGAGTTC CACCATGCTGAAAGCTGCGCTGGAGAAC GAATGTAGCTATGCGAGAGTTC CACCATGACCAAAGTTCCAGTTGTGAAGG GAATGTAGCTATGCGAGAGTTC CACCATGATGGTA...
Ngày tải lên: 29/03/2014, 21:20
Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc
... Attenuation of LXF-289 cell proliferation by ATP is mediated by the activation of the MEK ⁄ ERK1 ⁄ 2, PI3K and p38 MAPK pathways Activation and translocation of the transcription factors NF -jB1 (p50) and ... Table Inhibition of proliferation of LXF-289 lung tumor cells Effects of signaling pathway inhibitors on ATP-inhibited proliferation (A)...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo y học: "Enhanced expression of mRNA for nuclear factor κB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis" potx
... that of NFκB1 mRNA in bone marrow CD34+ cells Comparison of the expression of nuclear factor (NF )κB1 (p50) protein with that of NFκB1 mRNA in bone marrow CD34+ cells Purified bone marrow CD34+ cells ... expression of NFκB1 mRNA in bone marrow CD34+ cells would be important for delineation of the pathogenesis of RA...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis" potx
... Conclusion In summary, the S100A8/A9 < /b> heterodimer,< /b> highly expressed by < /b> synovial lining macrophage, may play a role in amplifying proinflammatory < /b> cytokine < /b> responses via < /b> activation < /b> of < /b> NF- B and p38 MAPK in ... for the DNA-binding activity of < /b> NF- B by < /b> EMSA As shown in Figure 7a, the NF- B activity was induced by...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility" pot
... collection of samples, and in the analysis and interpretation of results JJG-R coordinated the acquisition of clinical data and collection of samples, and participated in the analysis and interpretation ... interpretation of results AG participated in the design of the study and in the coordination of acquisition of clinical data and collectio...
Ngày tải lên: 09/08/2014, 14:20
Modulation of nuclear factor b signaling attenuates allergic airway inflammation 2
... al., 20 09; Lambrecht and Hammad, 20 12) These cytokines contribute to pathogenesis of < /b> allergic airway inflammation TSLP is hought to mediate polarization of < /b> Th -2 immune response (Holgate 20 12) Its ... (Lambrecht and Hammad, 20 12) Based on bronchial biopsy studies, the airways of < /b> subjects with asthma have fragile epithelial (Lackie, 1997; Lambrecht and Hamma...
Ngày tải lên: 08/09/2015, 18:36
Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2
... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B Through RNA interference of SKP1, a component of an ubiquitin ligase ... Role of Med21/hSrb7 in the Regulation of HSP70B 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal...
Ngày tải lên: 10/09/2015, 08:27
Báo cáo khoa học: Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1a ppt
... interaction with inhibitor of nuclear factor- kappaB alpha (IjBa) or p105 [the precursor of p50 nuclear factor- kappaB (NF-jB)] was discovered before its interactions with ASB4 and Notch-1 By using yeast ... an NF-jB inhibitor, IjBa, activated HIF -1a by sequestering an HIF -1a inhibitor, FIH During inflammation, IjBa is phosphorylated at Ser32 and Ser36 by IkB...
Ngày tải lên: 29/03/2014, 23:20
báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" doc
... Abbreviations used CGRP: calcitonin gene-related peptide CGRP; OPG: osteoprotegerin; RANK: receptor activator of nuclear factor-B; RANKL: receptor activator of nuclear factorB ligand; UHMWPE: ultra-high ... Miner Metab 2004, 22:19-25 doi:10.1186/1749-799X-5-83 Cite this article as: Xu et al.: Effects of alpha-calcitonin gene-related peptide on osteoproteg...
Ngày tải lên: 20/06/2014, 04:20
báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" pot
... Abbreviations used CGRP: calcitonin gene-related peptide CGRP; OPG: osteoprotegerin; RANK: receptor activator of nuclear factor-B; RANKL: receptor activator of nuclear factorB ligand; UHMWPE: ultra-high ... Miner Metab 2004, 22:19-25 doi:10.1186/1749-799X-5-83 Cite this article as: Xu et al.: Effects of alpha-calcitonin gene-related peptide on osteoproteg...
Ngày tải lên: 20/06/2014, 07:20
Báo cáo y học: "Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells" pps
... 5'-GCCTCCAGCATGAAAGTCTC, 3'-TAAAACAGGGTGTCTGGGGA), IL-1β (5'-TGCACGATGCACCTGTACGA, 3'-AGGCCCAAGGCCACAGGTAT), IL-6 (5'-GTTCCTGCAGAAAAAGGCAAAG, 3'-CTGAGGTGCCCATGCTACATTT), matrix metalloproteinase (MMP)-3 ... DHMEQ inhibits TNF-α-induced nuclear translocation of NF-κB, and does not inhibit phosphorylation and degradation of IκB, or a c-Jun N-terminal kinase (JNK) and a caspase...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: " Effects of intratracheal administration of nuclear factor-kappaB decoy oligodeoxynucleotides on long-term " ppsx
... analyzed whether intratra- Demonstration of activation in the lungs of 92 day smokeFigureon NF-κB the impact of local administration of decoy exposed1mice ODNs Demonstration of the impact of local ... ODNs on The effect of administration NF-κB decoy ODNs on the structure of pulmonary parenchyma and the expression of pro-MMP-9 or TIMP-1 in the long-term smoke-in...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment" pdf
... this inflammatory and catabolic cascade and demonstrated that curcumin (6) has the capacity to block the action of pro-inflammatory cytokines in the joint thus disrupting the inflammatory cycle inhibit ... intestinal absorption of curcumin is fairly low, mainly due to the fact that curcumin is practically insoluble in water, and that it has a low bio-availability [44,45] Despi...
Ngày tải lên: 12/08/2014, 14:22