Báo cáo y học: " Mesenchymal stem cells in autoimmune diseases: hype or hope" ppt

... underlying the possible in vivo immuno modulatory eff ects of MSCs remain a critical and unresolved question. By comparing side by side the eff ects of MSCs in vitro and in vivo, the study by ... Diaz F, Inostroza C, Rojo D, Mönckeberg G, Figueroa FE: Autologous mesenchymal stem cell treatment increased T regulatory cells with no e ect on disease activity in two systemic lu...

Ngày tải lên: 12/08/2014, 14:21

... Fattman C, Pandey AC, Torres G, Go K, Phinney DG: Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl ... cardiac injuries, at least partially by shifting the microenvironment at the injury sites from proinflammatory to anti-inflammatory [55-57]. In a murine pulmonary fibrosis model, MSCs inhib...

Ngày tải lên: 09/08/2014, 13:22

... Today 1990, 11:237-244. 59. Rasmusson I, Ringden O, Sundberg B, Le Blanc K: Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or ... Sundberg B, Sun- din M, Rosendahl K, Tammik C, Ringden O: Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymp...

Ngày tải lên: 11/08/2014, 08:21

... factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis. Arthritis Rheum 1998, 41:1258-1265. 39. Lindy O, Konttinen YT, Sorsa T, Ding Y, Santavirta S, Ceponis A, Lopez-Otin ... pathways and identify susceptibility genes or susceptibility effects that might be epistatic, additive or independent. Similarly, the psoriasis study analyzed a region previously identifi...

Ngày tải lên: 09/08/2014, 01:23

... HD cells showed increasing levels of p24 in the supernatants on both day-3 and day-5 post infection, suggesting a possible and crucial role in vivo in providing infectable cells. Interestingly, ... suppor t viral replication. Initially, the differentiated cells were ana lyzed for receptors, ligand binding, and cofactors, which are directly involved in HIV-1 infection, followed b...

Ngày tải lên: 13/08/2014, 01:20

... Khoury SJ, Weiner HL, Hafler DA: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1- secreting Th3 T cells by oral administration of myelin ... sites of inflammation from performing their regulatory function by pro-inflammatory cytokines. Similarly, although shown only for peripheral blood, it has been suggested that CD4 + CD25 +...

Ngày tải lên: 09/08/2014, 06:22

... M, Fiore JM, Furman RR, Niesvizky R, Shore T, Chadburn A, Horne H, et al.: Combination antibody therapy with epratuzumab and rituximab in relapsed or refractory non-Hodgkin’s lymphoma. J Clin Oncol ... with rituximab or other biologicals, as is suggested in the lymphoma experience. Competing interests RE has received support from Genentech for investigator and industry sponsored clini...

Ngày tải lên: 09/08/2014, 08:22

... function for transforming growth factor- beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nature Immunology 2008, 9:650-657. 9. Yang L, Anderson ... RA. Introduction Interleukin (IL)-17 may play a critical role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is capable of promoting inflammation by inducing a variety of pro-infla...

Ngày tải lên: 09/08/2014, 10:23

... Gavin MA, Rudensky AY: A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005, 6:1142-1151. 17. Marie JC, Letterio JJ, Gavin M, Rudensky AY: TGF- ββ 1 maintains suppressor ... apoptotic cells that bind to Toll-like receptor 7, Toll-like receptor 8, and Toll-like receptor 9 [84] expressed by DCs, and the proinflammatory cytokines produced by activated T cel...

Ngày tải lên: 09/08/2014, 13:22

... levodopa is temporarily useful for rigid- ity/bradykinesia and for tremor, and magnesium for muscle cramps in SCA2 patients [8], but neuroprotec- tive therapy is not clinically available. In 1999, Low ... Access Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells You-Kang Chang 1,2,3 , Ming-Hs...

Ngày tải lên: 10/08/2014, 10:20