Stem Cells in Endocrinology - part 4 ppsx

... selectin-E (8). y Hematopoietic cells were identified using H-CD 34 (Vector) for sialomucin-containing hematopoietic cells (8,13); Hermes-1 (DSHB) for CD 44 hyaluronate receptor (103–105); and H5A4 ... lineages in human ES. The inability of hES cells to maintain “stemness” in response to gp130-depen- dent JAK/STAT signaling is not exclusive to human cells. As described previ- ousl...

Ngày tải lên: 10/08/2014, 18:21

... insulin-expressing cells gradu- ally increased. To characterize the insulin-producing cells further, they mea- sured insulin secretion from 2 0- to 22-day-old EBs and 2 2- and 31-day-old, high-density ... select insu- lin-producing cells from spontaneously differentiating mouse ES cells (43 ). They introduced into the ES cells a plasmid conferring resistance to two antibiotics...

Ngày tải lên: 10/08/2014, 18:21

... culture Stem Cells in Endocrinology Edited by Linda B. Lester, MD CONTEMPORARY ENDOCRINOLOGY ™ Stem Cells in Endocrinology Edited by Linda B. Lester, MD Chapter 1 / Embryonic Stem Cells 7 3. ... SSEA-1 in mouse and SSEA-3 and SSEA -4 in human, and well as tumor-recognition antigens TRA- 1-6 0 and TRA- 1-8 1 in human. In the uncommitted state both mouse and...

Ngày tải lên: 10/08/2014, 18:21

... long as pluripotent stem cells remain lineage-uncommitted, they are unresponsive to progression agents (e.g., insulin, insulin-like growth factor-I, insulin-like growth factor-II) that accelerate ... self-renewal, far exceeding the mitotic clock of 50–70 population doublings for differentiated cells and lineage-committed tis- sue-specific cells. Germ layer lineage stem cells are te...

Ngày tải lên: 10/08/2014, 18:21

... islet-derived progenitor cells into insulin- producing cells. Endocrinology 2002; 143 :3152–3161. 54. Delacour A, Nepote V, Trumpp A, Herrera PL. Nestin expression in pancreatic exocrine cell lineages. ... M, Yokota H, et al. Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone. Stem Cells 2002;20:2 84 292. 42 . Kahan BW, J...

Ngày tải lên: 10/08/2014, 18:21

... Transplantation 1999;68 :48 0 48 4. Chapter 13 / Preclinical Trials for Stem Cell Therapy 243 243 From: Contemporary Endocrinology: Stem Cells in Endocrinology Edited by: L. B. Lester © Humana Press Inc., Totowa, ... Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland Diabetologia 19...

Ngày tải lên: 10/08/2014, 18:21

... 102–1 04, 1 34 140 , 143 , 147 –153, 158 Pluripotency, 4 6, 27, 49 , 94 95, 107, 136, 148 , 190, 244 Teratoma, 59, 149 , 236, 244 Generation of cell lines, 3–5, 25, 49 , 93, 99, 148 ICM, 4 7, 49 –50, 57, 148 Primate ... 192, 210, 246 – 247 Pluripotency, 8, 14, 54, 57, 86, 244 Self-renewal, 70–71, 74, 167, 247 Tumorigenicity, 244 Teratoma, 27, 53, 59 ES cells, 59, 101, 236, 244...

Ngày tải lên: 10/08/2014, 18:21

... for the inhibition of insulin release by epinephrine in man. J Clin Invest 46 , 86– 94. 172 INSULIN RESISTANCE IN GLUCOSE DISPOSAL AND PRODUCTION IN MAN translocation. Although hepatic insulin resistance ... (1983) Insulin-induced hypoglycemia in conscious dogs: effect of maintaining carotid arterial glucose levels on the adrenocorticotropin, epinephrine, and vasopressin responses....

Ngày tải lên: 09/08/2014, 15:20

... for Vα 14 NKT cells in IL-12-mediated rejection of tumors. Science 278:1623–26 196. Park SH, Kyin T, Bendelac A, Carnaud C. 2003. The contribution of NKT cells, NK cells, and other γ-chain-dependent ... formation in human CD1d heavy chain. J. Biol. Chem. 277 :44 838 44 89. Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. 2001. CD1d endosomal trafficking is independently r...

Ngày tải lên: 10/08/2014, 03:20