Ophthalmic Drug Delivery Systems - part 4 pdf

... intraocular sur- gery. Ophthalmology 98:227–228, 1991. 24. Peyman, G. A., and Schulman, J. A. Intravitreal drug therapy. In: Intravitreal Surgery. Norwalk: Appleton-Century-Crofts, pp. 40 7 45 5. 25. ... Inc. Similarrelationshipsbetweenretinalpermeability,vitreousdiffusivity,mole- cularweight,andhalf-lifehavebeenshownbyMaurice(32,36).Withinthe rangestudied,half-lifeisinverselydependentonth...

Ngày tải lên: 10/08/2014, 03:20

... Ocularpharmacokineticsincludesthefeaturesofabsorption,distribu- tion,andexcretionfoundwithsystemicadministrationbutappliedtothe eye.However,owingtotheuniqueanatomyandphysiologyoftheeyeand surroundingtissue,ocularpharmacokineticsisconsiderablymoredifficult todescribeandpredictthanitssystemiccounterpart.Thetaskisfurther complicatedbythevariousformulations,routes,anddosingregimenstypi- callyencoun...

Ngày tải lên: 10/08/2014, 00:20

... calculated at 4, 12, and 24 hours after injection, increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half- life, ... Inc. examinedthetransportkineticsofascorbateusingtherecentlydeveloped consciousanimalmodelwithmicrodialysissamplingofaqueoushumor. Microdialysisprobeswereplacedintheanteriorchambe...

Ngày tải lên: 10/08/2014, 00:20

... Mucoadhesive Polymers in Ophthalmic Drug Delivery 40 9 ThomasP.Johnston,ClaptonS.Dias,HemantAlur, andAshimK.Mitra 14. Microparticles and Nanoparticles in Ocular Drug Delivery 43 7 Murali K. Kothuri, ... of a series of 5 0 -ester prodrugs of 5-iodo-2 0 -deoxyuridine. Pharm. Res. 5:7 34 737, 1988. 10 Macha et al. Copyright © 2003 Marcel Dekker, Inc. Ophthalmic Drug Delivery...

Ngày tải lên: 10/08/2014, 00:20

... Animal Effect 2-Phenylethanol 0.5% Tilisolol, FD -4 , FD- 10 Rabbit Enhanced Papp 2.7 times for tilisolol, 5.6 times for FD -4 , and 4. 8 times for FD-10 Paraben 0. 04% Tilisolol, FD -4 , FD- 10 Rabbit ... applied drugs in the rabbit. Pharm. Res. 15:1882–1887, 1998. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4- phenylazobenzyloxycarbonyl-L-Pro-L...

Ngày tải lên: 10/08/2014, 00:20

... of drugs in perspective vis-a-vis ocular drug delivery. First, the noncorneal penetration pathway involves the per- meation of drug across the conjunctiva and sclera and may contribute sig- nificantly ... Routes of delivery: case studies. (7). Ocular delivery of peptide and protein drugs, Adv. Drug Delivery Rev., 8:331–339. 81. Chiou, G. C. Y. (19 94) . Systemic delivery of polyp...

Ngày tải lên: 10/08/2014, 00:20

... Absorption of vasopressin analogue, 1- desamino-8-D-arginine-vasopressin (dDAVP), in human intestinal epithelial cell line, CaCO-2, Int. J. Pharm., 64: 181. 43 . Amidon, G. L., Sinko, P. J., Hu, ... Pharm. Exp. Ther., 249 : 249 . 80. Ahmed, I., and Patton, T. F. (1985). Importance of the noncorneal absorption route in topical ophthalmic drug delivery, Invest. Ophthalmol. Vis. Sci., 2...

Ngày tải lên: 10/08/2014, 00:20

... adenovirus encoding brain-derived neurotrophic factor (Ad- BDNF) coinjected with a free radical scavenger, N-tert-butyl-(2-sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63% axotomized ... myocardium. Nature, 41 0(6829):701–705. 48 . Brown, J. M., Weissman, I. L., and Shizuru, J. A. (2001). Immunity to infec- tions following hematopoietic cell transplantation. Curr. Opin. Immun...

Ngày tải lên: 10/08/2014, 00:20

... 94: 12 744 –12 746 . 99. D. Pogocki and C. Schoneich. (2000). Chemical stability of nucleic acid- derived drugs. J. Pharm. Sci., 89 :44 3 45 6. 100. I. Jaaskelainen, J. Monkkonen, and A. Urtti. (19 94) . ... for gene delivery in vitro and in vivo. Adv. Drug Deliv. Rev., 24: 265– 271. 84. C. Plank, W. Zauner, and E. Wagner. (1998). Application of membrane-active peptides for drug and ge...

Ngày tải lên: 10/08/2014, 00:20