Insulin Action and Its Disturbances in Disease - part 2 pptx
Insulin Action and Its Disturbances in Disease - part 2 pptx
... (20 00) SOCS-3 is an insulin- induced negative regulator of insulin
signaling. JBiolChem275, 15 985–15 991.
22 2. Ahmed, Z. and Pillay, T. S. (20 01) Functional effects of APS and SH2-B on insulin
receptor ... preponderance in
dictating to glucose in ux into skeletal muscle in the absence and presence
of insulin.
68 INSULIN- MEDIATED REGULATION OF GLUCOSE METABOLISM
Table...
Insulin Action and Its Disturbances in Disease - part 3 pptx
... (eIF-4E), eIF-4G and phospho-
rylated heat–acid-stable protein (PHAS-1) are in uenced by insulin. PHAS-1
binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of
PHAS-1 and ... with insulin.
23
The synthesis of rRNAs has been
shown to increase after insulin treatment in a variety of cell types including
fibroblasts,
22 , 24
myoblasts
23
and hepatocytes....
Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity.
20 9
The resistin mRNA encodes
a 114-amino-acid polypeptide containing a 20 -amino-acid signal sequence. The
secreted protein, resistin, is a 94-amino-acid disulfide-linked ... acute role for leptin mediating insulin action remains undeter-
mined. However, the association of leptin with insulin resistance in type 2
diabetes and obesity may be through...
Insulin Action and Its Disturbances in Disease - part 7 pptx
... training with
annual check-ups
OGTT – fasting and
post-challenge
insulin
Reduction in 0,
40 min increment,
and 2 h insulin
during
intervention
(p<0.0001) in
intervention
groups, but not in
control ... kcal/week
(mainly brisk
walking).
No control group
Fasting insulin Unadjusted No change in insulin
level when
genotypes were
combined
Genotype modified
change in insul...
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... oestrogen biosynthesis 22 0
8 .21 Aromatase 22 0
8 .22 Sex steroids and body fat 22 2
8 .23 Summary 22 4
Acknowledgement 22 4
References 22 4
9PPARγ and Glucose Homeostasis 23 7
Robert K. Semple and Stephen O’Rahilly
9.1 ... expression in muscle, liver and fat,
109, 110, 1 12 –115
the
10 THE INSULIN RECEPTOR AND DOWNSTREAM SIGNALLING
L1′L2
L2′
insulin
Fn
Fn
CR CR′
e1 e...
Insulin Action and Its Disturbances in Disease - part 4 pdf
... (TNF-α), interleukin-6 (IL-
6), leptin, resistin, the renin–angiotensin system (RAS), plasminogen activator
inhibitor-1 (PAI-1) and more recently omentin and visfatin.
79
TheroleofTNF-α,
leptin, ... gluconeo-
genesis, and glycogenolysis. Diabetes 52, 26 0 26 7.
92. Boden, G., Cheung, P., Stein, T. P., Kresge, K. and Mozzoli, M. (20 02) FFA cause
hepatic insulin resistance by inhib...
Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased
activation of insulin receptor kinase.
91
11.4 Summary
Whole body insulin sensitivity is the product of a complex interaction ... years
BMI:
Ethnicity: Chinese
(Guangdong Province)
MOSPA
questionnaire
Fasting serum insulin
(Fasting insulin
resistance index: ‘a
multiplication
value of fasting
insulin and...
Insulin Action and Its Disturbances in Disease - part 8 pdf
... TNF-α.
22 7
TNF-α has also
been proposed to link obesity with insulin resistance, with serine phospho-
rylation of the insulin receptor substrate-1 being a prominent mechanism for
TNF-α-induced insulin ... fasting insulin, HOMA-IR index and total
LDL cholesterol concentrations.
26 2
Other mutations in the promoter ( 22 C →
A) and 3
UTR exon 9β (A → G in a AUUUA motif) have...
Insulin Action and Its Disturbances in Disease - part 9 pot
... and Pugeat, M.
(1995) Effect of diet and metformin administration on sex hormone-binding globulin,
androgens, and insulin in hirsute and obese women. J Clin Endocrinol Metab 80,
20 57 20 62.
92. ... within myocytes. This accumulation triggers PKC and IKK-
β-mediated serine phosphorylation of IRS-1, inhibiting insulin- induced tyrosine
phosphorylation of IRS-1 and IRS-1-ass...
Insulin Action and Its Disturbances in Disease - part 10 ppt
... and
visceral depots 21 5
adipocytokines 24 5–8, 476
adipogenesis 27 1
adipokines 66, 26 9–70, 26 9, 28 0
insulin resistance 27 2
adiponectin 27 9–80
interleukin-6 (IL-6) 27 4–6
leptin 27 6–8
resistin 27 8–9
tumour ... negative role in insulin signalling and its inhibition
improves insulin sensitivity.
SHIP2 is another negative regulator of insulin signalling. Overex...
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