cocaine and its metabolites in urine
Hydraulic modeling of open channel flows over an arbitrary 3-d surface and its applications in amenity hydraulic engineering
... depth-averaged model in a nonorthogonal curvilinear coordinates for prediction of flow pattern in meandering channel with 60o and 90o bend, and also with compound meandering channel. In this study, ... surface profile into vertical intake. In this regard, the model showed its applicability in computing the flow into intake with air-entrainment. The model was also applied to investigate the ... classified into two groups namely: the depth-averaged models in Cartesian coordinate system and the depth-averaged models in generalized curvilinear coordinate system. The basic assumption in deriving...
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Expansion and its realization in the short story “the law of life” by jack london
... “field, tenor and mode”. Field, tenor and mode determine the experiential meaning, interpersonal meaning and textual meaning, respectively. In order to understand a text, apart from its register, ... defining (restrictive) and non-defining (non-restrictive) relative clauses. According to Halliday (1994: 227) in terms of meaning, these clauses do not define subsets, in the way that a defining ... main character’s point of view. He is an old man left in a clearing by his tribe and his son with only a fire and some wood to burn in a few hours. And during this short moment he realized and...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... with GST-CD2 (MAP2 v-KIND binding core).Input (cerebellum)GSTv-KIND KIND1v-KIND KIND2Spir-2 KINDPTPN13 KINDInput (MAP2)GSTv-KIND KIND1v-KIND KIND2Spir-2 KINDPTPN13 KINDPD from cerebellar ... stain)EGFPEGFP-KIND2-1EGFP-KIND2-2EGFP-KIND2-3EGFP-KIND2-4EGFP-KIND2-5EGFP-KIND2EGFP-KIND1KIND2-1487KIND2-2521KIND2-3555KIND2-5589KIND2-4488456 620KIND2v-KIND+++––InteractionEGFPEGFP-KIND2-1InputIB: ... thev-KIND-MAP2 interaction within cells.The MAP2-binding core module of v-KIND isinvolved in targeting to neuronal dendrites and dendrite growthWe next investigated the MAP2 binding core ofv-KIND...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... In Changcells, stained occludin was observed in the cytoplasmicregion. Additionally, in OccWT-overexpressing Hep3B and Huh7 cells, regions stained with antibody to hem-agglutinin (HA), indicating ... levelincreased in OccWT-overexpressing cells, and that2-APB inhibited the effects of OccWT. Therefore,the increase in intracellular calcium may explain theinduction of apoptosis and reduction ... findings, our research provides new insights intothe role of exon 9 in the regulation of apoptosis and invasion in liver cell lines.ABFig. 7. Effects of occludin shRNA on apoptosis and invasiveness....
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... ofcopper binding could still allow domain swapping tooccur. It is of interest that a N-terminally truncated pri-on protein, lacking the copper binding domain is cap-able of domain swapping and forms ... places, but in particular, stefin B has a numberof histidines in the C-terminus (box in Fig. 1) at sites:92, 75, 66 and 58. As histidine residues are central tocopper binding in many proteins they ... fibrilformation of this protein is diminished in presenceof Cu2+ions. Another interesting finding is thatcopper binding gets less strong at pH 5, under fibrilpromoting conditions and that a mutant,...
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Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx
... mutations in the AUH gene. This indi-cated that AUH, in addition to its RNA binding func-tion, must play an important role in leucine catabolism.AUH was overproduced in E. coli and characterizedby ... usingcrotonyl-CoA as a substrate [15]. The gene encodingthis bifunctional protein was named AUH (‘AU bind-ing homolog of enoyl-CoA hydratase’). The RNA-binding activity of the human protein ... For thekinetic characterization of AUH described in the workat hand, AUH was overproduced in Escherichia coli asa maltose binding protein fusion (MBP-AUH). Thecomplete AUH gene (producing MBP-AUHp40...
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Tài liệu Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells ppt
... dynamic and complex class of vesicles, in which lysosomal cath-epsins are distributed in a nonrandom manner. MurineJ774 macrophages concentrate cathepsin H in earlyendosomes and cathepsin S in ... proline in cystatin F, thuspartially explaining the overall lowered affinity of cyst-atin F for these enzymes. Proline in the S2site is a fea-ture of human stefin A and cystatins F, S and ... general domain-swapping in the cystatin family[20]. Although both additional cysteines in cystatin Fat positions 1 and 37 (cystatin C numbering) can forma disulfide bond [13], the cysteine at position...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... Pireleased min)1Æmg)1of protein.Enzyme kinetic studyThe Km(Michaelis constant) and Vmax(maximum velocity)values were determined by incubating the diluted recombin-ant proteins in the standard ... deparaffinized and dehydrated using a graded series of alcohol and thenrehydrated in NaCl/Pi. The slides were blocked for 30 min in 1% H2O2 in NaCl/Picontaining 10% ethanol to inacti-vate ... at 26 000 g for 30 minat 4 °C. The supernatants containing recombinant proteinsof AsPPase were purified using ProBondTMresin (Invitro-gen) under nondenaturing conditions and subsequentlyeluted...
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Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf
... erythrocytes, and the difference between acetylcholinesterases of kid-ney and erythrocytes in the extent of binding with thelectins concanavalin A, Lens culinaris agglutinin(LCA), and Ricinus communis ... nicotinic receptors [19], amyloid b-peptide and presenilin-1 [20], neuronal enolase, the scaffold proteinRACK1 and protein kinase C [21], the corepressorCtBP [22], and Ran-binding protein [23]. ... ofAlzheimer’s disease in the brain in vivo.Neurobiol Aging doi:10.1016/j.neurobiolaging.2010.04.028.26 Vidal CJ (2005) Expression of cholinesterases in brain and non-brain tumours. Chem Biol Interact 157–158,227–232.27...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... resol-ving cysteine (Cys-SR). In typical 2-Cys, Spat the Nterminus and SRat the C terminus of the proteinbelong to different subunits and condense to form anintersubunit disulfide bond; in ... Spperoxidatic cysteine;X unidentified electron donor; SRresolvingcysteine; RSH protein or domain with CXXCmotif (e.g. thioredoxin). In typical 2-Cys, Spat the N terminus and SRat the C terminusbelong ... protein instability causedby oxidative stress conditions, are important in deter-mining the level of Bcp2 protein. Similar results areobserved for genes and related proteins involved in oxidative...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... a proteincontaining a single ankyrin repeat that interacts withHIV-1 viral protein R (Vpr) and we designated thisprotein as Vpr-binding ankyrin repeat protein(VBARP). This interaction was ... aprotinin, and protease inhibitors leupep-tin, chymostatin, and pepstatin (1 lgÆmL)1; Sigma) as des-cribed [14] for 15 min in ice. Cell lysates were centrifugedat 22 000 g for 10 min at ... play an important role in protein–protein interactions. ANKHD1 proteins are known to possessmultiple ankyrin repeat domains and a single KH domain with no knownfunction. Using yeast two-hybrid...
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Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc
... a-actinin, either in direct contact or in acomplex including the two proteins. In conclusion, our study proves the interaction betweena-actinin and calpain 1 and locates binding motifs withinregions ... Calp1 binding site in the C-terminal region of a-actinin [56] situates the protease in the vicinity of titin [57] and CapZ [34], two proteins describedas a-actinin partners in the Z-line and known ... cytoskeletalproteins [25,51].Binding interface between Calp 1 and ask was furtherlocated in this study. Calpain binding structures were foundwithin the 10 kDa C-terminal domain of the a-actininmolecule....
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Solar and Space Physics and Its Role in Space Exploration doc
... listed in the right-hand column of Table 2.1, indicates the mission’s objectives, and outlines its relevance to the space exploration initiative. Finally, one-page descriptions of the missions and ... vehicles into ionospheres and atmospheres, communication within and through planetary ionospheres, and survivability in the radiation environments of interplanetary space and within planetary ... weather on humans, instrumentation, and communications and spacecraft systems. To that end, input from space physics observations and analysis will help in modeling and developing predictive capabilities...
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PULMONARY TUBERCULOSIS AND ITS MANAGEMENT IN CLASSICAL UNANI LITERATURE pptx
... lean and thin. Body skin is dry and thin. Face turns pale and eyes sink. The facial bones become prominent and bones and skin come in contact due to wasting. Both temporal sink. Clinical features ... days and is of low grade and does not have the symptoms of infectious fever like chills, rigors, thirst, irritability, dryness of tongue and foul smelling urine. The patient becomes lean and ... disease, Sil and the causing agent Ajsame Khabitha (microorganisms). Symptoms and signs Pulse is subtle, firm, continuous and weak. Fever is continuous till morning. Fever is constant and due...
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THE MINE WATER POLLUTION THREAT TO WATER RESOURCES AND ITS REMEDIATION IN PRACTICE pdf
... this decision-making process in practice: Wheal Jane and South Crofty (Cornwall), Quaking Houses (Co Durham), Hlobane Colliery (South Africa) and Milluni Tin Mine (Bolivia). In many cases, particularly ... frequent contaminants are Fe, Mn, Al and SO4, with locally important contributions by other metals / metalloids including (in order of decreasing frequency) Zn, Cu, As, Ni, Cd and Pb. Remedial ... 1THE MINE WATER POLLUTION THREAT TO WATER RESOURCES AND ITS REMEDIATION IN PRACTICE PAUL L. YOUNGERPollution by mine drainage is a major problem in many parts of the world....
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- and drive down costs by increasing efficiencies six sigma has proven its value in all these areas
- cocaine and its metabolites
- and its treatment in a machine translation system s
- events in a document and its application
- distributivity in chinese and its implications
- characteristics of obesity and its related disorders in china
- excretion of cocaine and its metabolites in man
- detection of cocaine and its metabolites in breast milk
- detection of cocaine and its metabolites
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