Báo cáo y học: "Genome-wide association studies in systemic lupus erythematosus: a perspective" docx

... Suarez A, Junker P, Laustrup H, Gonza- lez-Escribano MF, Martin J, Abderrahim H, Alarcon-Riquelme ME: Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. ... independently validated loci that, together with additional targets generated by larger GWAS, can be used to piece together the key pathways involved in lupus pathogenesis, with each...

Ngày tải lên: 09/08/2014, 14:22

... because epratuzumab conjugated with toxin or radiolabel leads to substantially higher response rates in B cell lymphomas than the agent alone [10]. Such approaches also create more clinical adverse ... reactions and would probably not be acceptable for use in SLE. Another curious finding in the lymphoma experience is that combining epratuzumab with rituximab, although not increasing the...

Ngày tải lên: 09/08/2014, 08:22

... cells in patients with systemic lupus erythematosus. Zhonghua Yi Xue Za Zhi 2008, 88:453-456. 60. Alvarado-Sanchez B, Hernandez-Castro B, Portales-Perez D, Baranda L, Layseca-Espinosa E, Abud-Mendoza ... differen- tiation, maturation and secretion of proinflammatory cyto- kines, suggesting they are in a preactivated state [66,67] – although not all workers agree [68]. The numbers of...

Ngày tải lên: 09/08/2014, 13:22

... hemoglobinuria in systemic lupus erythematosus: a case report Norio Nakamura 1* , Toshiyuki Sugawara 2 , Ken-ichi Shirato 2 , Ryuichiro Kumasaka 2 , Masayuki Nakamura 2 , Michiko Shimada 2 , Takeshi ... nausea, general fatigue, and severe pancytopenia and was admitted to our hospital. A laboratory evaluation showed hemolytic anemia. Further examination showed a neutrophil...

Ngày tải lên: 10/08/2014, 22:20

... anti-dsDNA antibody-mediated injury. Anti-dsDNA antibodies and lupus pathophysiology Anti-dsDNA antibodies and SLE pathophysiology are currently quite loosely connected in both classification and clinical practice. ... erythematosus [14], there is little evidence that anti-dsDNA antibodies are pathophysio- logically involved in other clinical manifestations. Recent findings that intrath...

Ngày tải lên: 09/08/2014, 06:22

... Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yas- utomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S: Association of STAT4 ... Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H,...

Ngày tải lên: 09/08/2014, 14:20

... HLA -A1 , HLA-B8, HLA-DR3 haplotype, in at least one healthy Caucasian population [11]. Furthermore, using a large UK Caucasian sample, Ahmad and coworkers [12] recently reported that TPSN polymorphisms ... and microcytotoxicity assays. Preliminary association analysis was conducted by χ 2 test- ing on contingency tables comparing the three genotypic frequencies between cases and contr...

Ngày tải lên: 09/08/2014, 06:22

... serum amyloid A (SAA) [16]. Since SAA is a known biomarker of active SJIA [17], we compared the intensity of the 11.6-kDa peak with SAA levels in the sera, as determined by latex agglu- tination. As ... Medicine, Yokohama, Japan. All the patients were Asian and their mean age at the start of the study was 7.25 ± 0.92 years. Eight of them had obtained a clinical response to conventiona...

Ngày tải lên: 09/08/2014, 06:22

... TAMRA 3' 5' GAC AAA TCA TCT TCA TCA CCA CCA C 3' 99.77% ADAMTS 5 5' GGA CCT ACC ACG AAA GCA GAT C 3' 5' 6 FAM – CCC AGG ACA GAC CTA CGA TGC CAC C – TAMRA 3' 5' ... CC 3' 5' 6 FAM – CCC CCA CCC TGG CTC TGA CCA – TAMRA 5' TCA TGA CCT GCC AGA GAG AAC A 3' 99.22% MMP-13 5' CCC CAG GCA TCA CCA TTC AAG 3' 5' 6 FAM –...

Ngày tải lên: 09/08/2014, 10:20

... 3'-gttcgggaaccggattattta-3'; CDC2: 5'-ggtcaagtggtagccatgaaa-3' and 3'-ccaggagggata- gaatccaag-5'; and MKI67: 5'-ccccaaccaaaagaaagtctc-3' and 3'-gactaggagctggagggctta-5'. Histopathology ... 5'-gcccagctatgaactccttct-3' and 3'-tgaagaggtgagtggctgtct-5'; INDO: 5'-ggtcatggagatgtc- cgtaa-3' and 3'-accaatagagagaccagg...

Ngày tải lên: 09/08/2014, 14:20