Báo cáo y học: "Targeting B cells in systemic lupus erythematosus: not just déjà vu all over again" pdf

... would probably not be acceptable for use in SLE. Another curious finding in the lymphoma experience is that combining epratuzumab with rituximab, although not increasing the overall clinical response ... that epratuzumab will be shown to improve SLE clinically, then the lack of biological markers of its effects may in fact be a drawback to its rational use. Because even the fall in...

Ngày tải lên: 09/08/2014, 08:22

... not only is responsible for Treg differentiation, but also prevents these cells from becoming Th17 proinflammatory effector cells. Depletion of Review Regulatory T cells in systemic lupus erythematosus: ... [84] expressed by DCs, and the proinflammatory cytokines produced by activated T cells, continuously stimulate immature DC to become immunogenic antigen-presenting cells....

Ngày tải lên: 09/08/2014, 13:22

... INF- producing pDCs during HIV infection [13] may contribute to this protective effect of HIV. DCs can be infected by HIV, and TLR9 signalling-changes in pDC function may be reduced indirectly by HIV ... pDC in HIV infection usually parallels the loss of CD4 [15], but the rate of recovery of DC and CD4 T cells may be independent. What factors may have been important in the develop- me...

Ngày tải lên: 11/08/2014, 17:21

... focusing on the organ specificity of anti-dsDNA antibody-mediated injury. Anti-dsDNA antibodies and lupus pathophysiology Anti-dsDNA antibodies and SLE pathophysiology are currently quite loosely ... cutaneous lupus erythematosus [14], there is little evidence that anti-dsDNA antibodies are pathophysio- logically involved in other clinical manifestations. Recent findings that intratheca...

Ngày tải lên: 09/08/2014, 06:22

... Janus-family tyrosine kinase that is bound to cytokine receptors and becomes activated after ligand binding. Defi- ciency of TYK2 leads to defects of multiple cytokine pathways, including type I interferon, ... protein with ankyrin repeats 1; BLK: B- lymphoid tyrosine kinase; GWA: genome-wide association; IL: interleukin; ITGAM: integrin alpha M; LY9: lymphocyte antigen 9; MECP2: methyl CpG...

Ngày tải lên: 09/08/2014, 14:20

... hemolytic anemia due to the increased susceptibility of the erythrocyte membrane to complement-mediated lysis; (b) thrombosis in large vessels, such as hepatic, abdominal, cerebral, and subdermal ... proteinuria with serological and hematological abnormalities – the titers of anti-nuclear antibody and double-stranded DNA (dsDNA) antibody Paroxysmal nocturnal hemoglobinuria in systemi...

Ngày tải lên: 10/08/2014, 22:20

... system, such as the one we currently have in the US.  us, it is gratifying to note the study by Yazdany and colleagues [1] in this issue of Arthritis Research &  erapy. In this study ... particularly if the latter assumes incorrectly that all health-related issues (preventive services included) are being taken care of by the former. Such assumptions are not uncommon in...

Ngày tải lên: 12/08/2014, 14:22

... fragment binding. T -cells did not show any epratuzumab binding and were subsequently used as negative control. Notably, we did not observe any significant inhibition of epratuzumab binding on monocytes ... H7-allophycocyanin; ITIMs: immunoreceptor tyrosine-based inhibitory motifs; mAb: monoclonal antibody; MFI: mean fluorescence intensity; MIG: monokine induced by gamma interferon; PB:...

Ngày tải lên: 12/08/2014, 15:21

... of T effector cells to the suppressive effects of Tregs [54]. Finally, although suppression by Tregs is probably not antigen-specific but might involve neighboring T cells in a ‘bystander’ fashion ... Khoury SJ, Weiner HL, Hafler DA: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1- secreting Th3 T cells by oral administ...

Ngày tải lên: 09/08/2014, 06:22

... ionomyocin (1 μg/ml) plus brefeldin A (10 μg/ml) for four hours. Cells were blocked with 50% human serum and 0.5% bovine serum albumin in phos- phate buffered saline and incubated with allophycocyanin- conjugated ... critical role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is capable of promoting inflammation by inducing a variety of pro-inflammatory media- tors, including...

Ngày tải lên: 09/08/2014, 10:23