Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P42 pot
Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P42 pot
... 84preoperative PVE, goal, 84TACE, randomized arterial emboliza-tion trials, 84medical oncologistsorafenib, molecular targeted therapies, 84systemic therapy for HCC, use of, 84pathologist, ... subtypes, WHOclassification, 38trabecular, pseudoglandular(acinar),compact, and scirrhous, 38, 38f–39fHistologic variants of HCCcombined HCC and cholangiocarcinomas,42–43fibrolamellar HCC, ... 30molecular examples and pathways, 29, 29tMicrometastatic disease, 219Microscopic features of HCC, 37cytologic subtypes of HCC, 40–41histologic patterns of HCC, 38–40Microsphere Embolotherapy, 320–322Microsulis...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P2 potx
... Pritesh Mutha, and Sanjay Gupta21 Cytotoxic Chemotherapy and Endocrine Therapy for Hepatocellular Carcinoma 337Daniel Palmer and Philip J. Johnson22 Targeted Therapies for Hepatocellular Carcinoma ... Albany, and Ghassan K. Abou-Alfa23 The Future: Combination Systemic Therapy for Hepatocellular Carcinoma 369Ahmed O. Kaseb and Melanie B. Thomas24 Follow-Up and Salvage Therapy for Recurrent Hepatocellular ... 239Robin D. Kim and Alan W. Hemming16 Radiofrequency Ablation for Hepatocellular Carcinoma 261E. Ramsay Camp, Nestor F. Esnaola, and Steven A. Curley17 Microwave Ablation and Hepatocellular...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P3 pot
... positive association between hypothyroidism and HCCamong women [98].Whether and why hypothyroidism causes HCC is not clear. However, the asso-ciation between hypothyroidism and NASH can be explained ... diabetes-induced dyslipidemia and may explain ourobservation of HCC risk modification among patients with hypothyroidism and diabetes [98].1 Epidemiology and Pathogenesis of Hepatocellular Carcinoma ... of anti-HCV and HCV RNA in alcohol users and those among them who develop alcoholicliver diseases [43]. Despite this close relationship, there is little understanding ofhow HCV and alcohol...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P4 potx
... of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer101:1009–10171 Epidemiology and Pathogenesis of Hepatocellular Carcinoma ... doublings and breach the mortalitybarrier to acquire unlimited replicative potential. Telomeres, which are composedof several thousand repeats of a short six base-pair sequence element, and whichare ... genes and miRNAs in biological pathways. Furthermore, signif-icant and complex cross talks among the different pathways exist and are involvedin different aspects of HCC development and progression....
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P10 potx
... system (and related JIS score) may, however,have particular advantages in patients with early HCC. As the therapeutic modalitiesavailable for HCC and the indications for aggressive therapy expand, ... multimodal-ity therapy can be expected to challenge our understanding of prognostic factorsin HCC.References1. Okuda K, Ohtsuki T, Obata H et al (1985) Natural history of hepatocellular carcinoma and prognosis ... prognostic systemfor hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology 28:751–7553. Llovet JM, Bru C, Bruix J (1999) Prognosis of hepatocellular carcinoma: the BCLC...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P12 pot
... small hepatocellular carcinoma: a prospective study. Ann Surg242:36–4217. Chen MS, Li JQ, Zheng Y et al (2006) A prospective randomized trial comparing percuta-neous local ablative therapy and ... and above a certain level and reflects it, and it is useful for explaining the complex decision-making process to patients ina way that is easy to comprehend, and for obtaining their understanding ... unresectable hepatocellular carcinoma: a randomized controlled trial. Lancet 359:1734–173911. Minagawa M, Makuuchi M, Takayama T et al (2001) Selection criteria for hepatectomyin patients with hepatocellular...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P14 potx
... (TLV) is defined asthe standardized FLR (sFLR) and it provides the percent of TLV remaining after resectionPreoperative Therapy Transarterial Chemoembolization (TACE) and Portal Vein Embolization(PVE)In ... mechanism of intrahepatic recurrence, and laterto extrahepatic organs such as the lungs, bone, and adrenal glands. These two formsof spread, vascular invasion and intrahepatic metastasis, are among ... parenchyma.Advances in anesthetic and surgical techniques, as well as a thorough understandingof the liver anatomy and tumor biology, have contributed dramatically to the safety and effectiveness of liver...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P15 pot
... fibro-lamellar hepatocellular carcinoma. A study of nine cases and a review of the literature. AmJ Surg. 151:518–52399. Okuda K (2002) Natural history of hepatocellular carcinoma including fibrolamellar and hepato-cholangiocarcinoma ... of tumor growth rate and patient survival. Hepatology 16:132–1373. Shuto T, Hirohashi K, Kubo S et al (1998) Changes and results of surgical strategies for hepatocellular carcinoma: results of ... chemotherapy for a previously unresectable hepatocellular carcinoma.J Hepatobiliary Pancreat Surg 13:347–35043. Lau WY, Leung TW, Lai BS et al (2001) Preoperative systemic chemoimmunotherapy and sequential...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P16 potx
... veins aslandmarks to reduce the risk of major morbidity and mortality.Definition of the tumor–vessels relationship is relevant for planning the type ofresection, and based on that, specific and original ... vein could be thicker and not immediately differentiable from a peripheral portal branch. Following theportal pedicles at the sectional, segmental, and subsegmental levels and positioningit in ... abdominal cav-ity, liver mobilization dividing the round and falciform ligaments, and division ofeventual adhesions to free the antero-superior and inferior surfaces of the liver arethe steps that...
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Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P20 potx
... remnant, and recognition of the physiologic effectof the type of hepatic and extrahepatic procedure planned, permits the appropriateselection of patients for PVE. The FLR should be measured and standardized ... function and posthepatectomy course and the utility of PVE in patientswith HCC. Palavecino and colleagues [112] evaluated 54 patients that underwentmajor hepatic resection for HCC between 1998 and ... these perioperative deaths, the overall survival rates at1, 3, and 5 years were 94, 82, and 72% in the PVE group and 93, 63, and 54% inthe non-PVE group, respectively ( P = 0.35). Similarly,...
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