Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P3 pot

... positive association between hypothyroidism and HCC among women [98]. Whether and why hypothyroidism causes HCC is not clear. However, the asso- ciation between hypothyroidism and NASH can be explained ... diabetes-induced dyslipidemia and may explain our observation of HCC risk modification among patients with hypothyroidism and diabetes [98]. 1 Epidemiology and Pathogenesis of H...

Ngày tải lên: 07/07/2014, 09:20

... Pritesh Mutha, and Sanjay Gupta 21 Cytotoxic Chemotherapy and Endocrine Therapy for Hepatocellular Carcinoma 337 Daniel Palmer and Philip J. Johnson 22 Targeted Therapies for Hepatocellular Carcinoma ... Albany, and Ghassan K. Abou-Alfa 23 The Future: Combination Systemic Therapy for Hepatocellular Carcinoma 369 Ahmed O. Kaseb and Melanie B. Thomas 24 Follow-Up and Sal...

Ngày tải lên: 07/07/2014, 09:20

... of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer 101:1009–1017 1 Epidemiology and Pathogenesis of Hepatocellular Carcinoma ... doublings and breach the mortality barrier to acquire unlimited replicative potential. Telomeres, which are composed of several thousand repeats of a short six base-pair sequence elem...

Ngày tải lên: 07/07/2014, 09:20

... system (and related JIS score) may, however, have particular advantages in patients with early HCC. As the therapeutic modalities available for HCC and the indications for aggressive therapy expand, ... multimodal- ity therapy can be expected to challenge our understanding of prognostic factors in HCC. References 1. Okuda K, Ohtsuki T, Obata H et al (1985) Natural history of hepatocel...

Ngày tải lên: 07/07/2014, 09:20

... small hepatocellular carcinoma: a prospective study. Ann Surg 242:36–42 17. Chen MS, Li JQ, Zheng Y et al (2006) A prospective randomized trial comparing percuta- neous local ablative therapy and ... and above a certain level and reflects it, and it is useful for explaining the complex decision-making process to patients in a way that is easy to comprehend, and for obtaining th...

Ngày tải lên: 07/07/2014, 09:20

... (TLV) is defined as the standardized FLR (sFLR) and it provides the percent of TLV remaining after resection Preoperative Therapy Transarterial Chemoembolization (TACE) and Portal Vein Embolization (PVE) In ... mechanism of intrahepatic recurrence, and later to extrahepatic organs such as the lungs, bone, and adrenal glands. These two forms of spread, vascular invasion and intrahep...

Ngày tải lên: 07/07/2014, 09:20

... fibro- lamellar hepatocellular carcinoma. A study of nine cases and a review of the literature. Am J Surg. 151:518–523 99. Okuda K (2002) Natural history of hepatocellular carcinoma including fibrolamellar and hepato-cholangiocarcinoma ... of tumor growth rate and patient survival. Hepatology 16:132–137 3. Shuto T, Hirohashi K, Kubo S et al (1998) Changes and results of surgical str...

Ngày tải lên: 07/07/2014, 09:20

... veins as landmarks to reduce the risk of major morbidity and mortality. Definition of the tumor–vessels relationship is relevant for planning the type of resection, and based on that, specific and original ... vein could be thicker and not immediately differentiable from a peripheral portal branch. Following the portal pedicles at the sectional, segmental, and subsegmental levels and...

Ngày tải lên: 07/07/2014, 09:20

... remnant, and recognition of the physiologic effect of the type of hepatic and extrahepatic procedure planned, permits the appropriate selection of patients for PVE. The FLR should be measured and standardized ... function and posthepatectomy course and the utility of PVE in patients with HCC. Palavecino and colleagues [112] evaluated 54 patients that underwent major hepatic resect...

Ngày tải lên: 07/07/2014, 09:20

... open resection and the need for blood transfusion were 9.2 and 9.8%, respec- tively. There were 2 postoperative deaths and the morbidity was detailed as liver specific in 11.6% and nonspecific ... injection therapy for hepatocellular carcinoma: results in 146 patients. AJR Am J Roentgenol 160(5):1023–1028 6. Matsukawa T, Yamashita Y, Arakawa A, et al (1997) Percutaneous microwave...

Ngày tải lên: 07/07/2014, 09:20