10 treatment of hepatocellular carcinoma and liver metastases

... Association for the Study of the Liver criteria [5] and the left liver lobe hypertrophy in the interim, surgical resection of the right liver and segment IV A was discussed and CT volumetry was performed ... (a) The primary tumor Adenoid cystic carcinoma of the left submandibular salivary gland is indicated by the circle (b) and (c) Computed tomography (CT) of the liver before chemoembolization showing ... for colorectal and neuroendocrine tumor metastases [11] Drug-eluting microspheres have been introduced recently and have been used for the treatment of hepatocellular carcinoma and metastatic...

Ngày tải lên: 10/08/2014, 23:20

... alterations of tumor cells and contributes to the growth of prostate carcinoma and is a predictor of aggressive features of this cancer [14,15] Up to date, the clinicopathologic/prognostic implication of ... factors and surveillance of hepatocellular carcinoma Eur Rev Med Pharmacol Sci 14:352-355 Frau M, Biasi F, Feo F, Pascale RM: Prognostic markers and putative therapeutic targets for hepatocellular carcinoma ... aggressive features and poor prognosis of hepatocellular carcinoma Journal of Translational Medicine 2011 9:5 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient...

Ngày tải lên: 18/06/2014, 16:20

... Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation Hepatology 2005;41:1130-37 Takano S,Yokosuka O, Imazeki F et al Incidence of hepatocellular carcinomain ... hepatitis B and C : a prospective study of 251patients Hepatology 1995;21:650-655 Otto G Heuschen U, Hofman WJ et al Survival and recurrence after liver transplantation versus liver resection for hepatocellular ... Diseases of the Liver and Biliary Tract Standardization of Nomenclature, Diagnostic Criteria and Prognosis New York: Raven Press, 1994 Salmi A., Turrini R, Lanzani G, et al Long term effectiveness of...

Ngày tải lên: 08/08/2014, 17:20

... improved delivery of radiochemotherapy by integration of techniques such as IMRT to reduce toxicity, a better understanding of tumour response by research on molecular profiles to predict pCR and finally ... radiochemotherapy [31] The problem with some of these trials is that - by current standards - low to moderate doses were used because of crude methods of radiation planning and delivery at the time Three other ... sensitivity and specificity of 71% (95% CI, 62%-79%) and 93% (95% CI, 89%-97%) [51,52], which is crucial for the differentiation between locoregional and systemic disease In adenocarcinomas of the...

Ngày tải lên: 09/08/2014, 09:20

... al.: More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells Journal of Experimental & Clinical ... LX, Tang ZY, Wang XW: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment Cancer Cell ... expressions of BDNF and TrkB were examined in 65 cases of HCC by means of immunohistochemistry to evaluate the involvement of BDNF/TrkB in the progression of HCC BDNF was found up-regulated and TrkB...

Ngày tải lên: 10/08/2014, 10:21

... effect of radiation on lung metastases of hepatocellular carcinoma: a case report Journal of Medical Case Reports 2011 5:111 Author details Department of Radiation Oncology, University of Tokyo ... regression of hepatocellular carcinoma: a case report and literature review Hepatogastroenterology 2004, 51(56):579-582 Hall E: Radiobiology for the Radiologist Philadelphia: Lippincott, Williams and ... Mizutani Y, Nagamuta M, Ikenaga M: Effects of X-ray irradiation on natural killer (NK) cell system I Elevation of sensitivity of tumor cells and lytic function of NK cells Immunopharmacol Immunotoxicol...

Ngày tải lên: 11/08/2014, 00:23

... values for sTNFR-II and IL-8 among PNALT and HCC patients yielded a cutoff of 398 pg/ml and 345 pg/ ml, respectively, as shown in Table 4, and Figures and ROC curve for IL-2R and sFas is shown ... positive patients; the copy numbers of HCV-RNA were × 106 and × 106/gm wet weight of HCC, and × 107 and 3.2 × 108/gm wet weight of cirrhotic liver tissues from patient-1 and -2, respectively [42] The ... binding of IL-2 due to excess of its receptor and thus inducing an inhibition of the appropriate immune response with subsequent progression of chronic liver disease and the development of HCC...

Ngày tải lên: 13/08/2014, 13:20

... metastasis of hepatocellular carcinoma Hepatology 49: 1571–1582 Bai S, Nasser MW, Wang B, Hsu SH, Datta J, et al (2009) MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and ... in development of cirrhosis and liver cancer and tumor metastasis [3,4,14] as spontaneous liver tumors were observed in Mir122a–/– mice, whereas reduced disease manifestation and tumor incidence ... clinical outcomes of the HCC patients We also demonstrated the strong anti-correlation of miR-122 and PKM2 expression levels in the cohort of 94 HCC samples Targeted delivery of miR-122 into HCC...

Ngày tải lên: 23/09/2015, 14:47

... Management of hepatitis C virus infection in the setting of liver transplantation Liver Transpl 2005; 11:479-89 Charlton M Liver biopsy, viral kinetics, and the impact of viremia on severity of hepatitis ... immunosuppression and acute rejection on recurrence of hepatitis C: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database Liver Transpl Surg ... the diagnosis and management of hepatitis C in the peri -liver transplant period, as well as the management of the complications of chronic liver diseases Paul Martin M.D is Professor of Medicine...

Ngày tải lên: 31/10/2012, 17:08

... diagnosis and management of skin and soft-tissue infections Clin Infect Dis 2005;41(10):1373–406 May AK, et al Treatment of Complicaed Skin and Soft Tissue Infections Surg Infect 2009;10(5):467–99 Anderson ... of .500 IU/L compared to standard treatment (9.5% of 116 vs 1.5% of 111, P  =  0.04) However, only three of these patients required discontinuation of daptomycin.62 A retrospective analysis of ... confirmation of compliance with legal and ethical obligations including but not limited to the following: authorship and contributorship, conflicts of interest, privacy and confidentiality and (where...

Ngày tải lên: 22/03/2014, 14:20

... to regard on the one hand the natural course of the disease, the risk of rupture, and the life expectancy of the patient, and on the other hand the morbidity and mortality of the prophylactic surgical ... to regard on the one hand the natural course of the disease, the risk of rupture, and the life expectancy of the patient, and on the other hand the morbidity and mortality of the prophylactic surgical ... by all kinds of aortic aneurysms and dissections, not only AAA 58.7 % of these patients were 75 years of age or older These were 0.53% of all deaths, and 0.58% of the deaths in men and women over...

Ngày tải lên: 28/06/2014, 05:20

... Cooperative Study Group on Hepatocellular Carcinoma: Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma Arch Surg 2005, ... DeMatteo RP: Outcome of partial hepatectomy for large (> 10 cm) hepatocellular carcinoma Cancer 2005, 104:1948-1955 11 Edmondson HA, Steiner PE: Primary carcinoma of the liver A study of 100 cases among ... design and coordination of the study, carried out the critical appraisal of studies and wrote the manuscript CS, ZL, and YZ developed the literature search, carried out the extraction of data,...

Ngày tải lên: 09/08/2014, 01:24

... with synchronous double primary cancer of the gallbladder and liver, so additional resection of extrahepatic bile duct and segment of liver, with a dissection of regional lymph nodes, was performed ... cancers of gallbladder, common bile duct and liver in a women with primary biliary cirrhosis [5] In our case, two different type malignant tumors, adenocarcinoma of gallbladder and hepatocellular carcinoma, ... tumor of the gallbladder and liver: a case report World Journal of Surgical Oncology 2011 9:84 Conclusions We report the first case of synchronous double primary malignancies of gallbladder and liver...

Ngày tải lên: 09/08/2014, 02:20

... incidence of intracystic carcinoma of the breast in men appears to be higherand and there is equal to or more than % of report [5,6] Most patients with intracystic carcinoma of the breast have symptoms ... operated this case and analyzed all data SH and YM, KS did the assistant of the operation NM diagnosed h the pathology of this case TS is the professor of the surgical science and had a guide All ... wall was investigated as intracystic carcinoma of the breast Patients with intracystic carcinoma of the breast tend to be older than patients with other forms of breast cancer In our study, the...

Ngày tải lên: 09/08/2014, 02:21

... http://www.wjso.com/content/8/1/92 Page of Figure A Histologic appearance of combinations of small, ductal and squamous cellular components of the tumor (H & E, x100) B Transitional area between squamous cell carcinoma and neuroendocrine ... Most of maxillary sinus cancer was SCC and adenocarcinoma SNEC of the sinonasal region is the least common of the sinonasal carcinomas with neuroendocrine differentiation The SCC or adenocarcinoma ... nasopharyngeal carcinoma, and undifferentiated sinonasal carcinoma SNEC has been reported to stain strongly with synaptophysin and CD56 nerve cell adhesion molecule and weakly with chromogranin A and CAM...

Ngày tải lên: 09/08/2014, 03:22

... although hematogenous skull metastases can be caused by nearly all types of tumors [11] Because of the wide spectrum of primary cancers causing skull metastases, and because of their indistinguishable ... eosinophilic cytoplasm and prominent nucleoli arranged in both a trabecular and solid pattern, which is consistent with metastasis of HCC In spite of the low incidence of skull metastases, there have ... most skull metastases appear as osteolytic, expansile, and hypervascular lesions [10] Metastases are the most common cranial neoplasms in adults, of which 60% are from breast and lung carcinoma, ...

Ngày tải lên: 09/08/2014, 07:21

... explained by the predominance of the randomised and non-randomised ESPAC-1 patients in the meta-analysis from Stocken et al [28] on the one hand and by the inclusion of the non-randomised Yeo et al data ... of the options of standard of care based on the GITSG- and RTOGdata [18], in Europe adjuvant chemotherapy is preferentially given • To define the role of adjuvant CRT, a large randomised study ... median OS times of 10-11 months and 1-year-survival rates of up to 40% [47,63-66] The value and particularly the toxicity of additive chemotherapy before or after CRT have to be Brunner and Scott-Brown...

Ngày tải lên: 09/08/2014, 09:20

... Kpn I and Xhol I sites of the pGL3-Basic luciferase reporter vector (Promega, Madison, WI) In brief, x105 cells were seeded the day before transfection Then, ug of plasmid DNA and ul of LipofectAMINE ... Figure Verification of difference of OPN and c-Myb expression in HCC cell lines HCCLM6 cells expressed high level of OPN and c-Myb compared with SMMC-7721 cells (A) Relative OPN and c-Myb mRNA levels ... electrophoresis and western blot Briefly, twenty micrograms of total protein were separated by standard SDSPAGE and then transferred to PVDF membranes The membranes were washed, blocked, and incubated...

Ngày tải lên: 10/08/2014, 10:20

... ultrasound, CT and MRI have been widely used to detect HCC, PET has remained out of favor for the diagnosis of HCC because of the lack of differentiation between HCC glucose metabolism and normal liver ... HCC: hepatocellular carcinoma; MRI: magnetic resonance imaging; PET: positron emission tomography; SUV: standardized uptake value Page of Author details Department of Medical Oncology, City of ... incidence of hepatocellular carcinoma in the United States: an update Ann Intern Med 2003, 139:817-823 Kemp W, Pianko S, Nguyen S, Bailey MJ, Roberts SK: Survival in hepatocellular carcinoma: impact of...

Ngày tải lên: 11/08/2014, 00:23

... attenuate the synthesis of inflammatory cytokines and MMPs [17] SB 203580 [19-21] and VX-745 [22] are both potent inhibitors of p38α and β but not γ or δ The specificity of a number of widely used p38 ... rules and regulations of the State of Ohio Departments of Health, and in accordance with the Procter& Gamble company policy of research involving animals with strict oversight for care and welfare ... and received an intra plantar injection of 0.100 ml of a 1.2% solution (w/v) of Carrageenan Viscarin GP 109 and returned to his cage to recover Four hours post injection; the left hind limb of...

Ngày tải lên: 11/08/2014, 08:22