Muscle Gene Therapy doc

... incurable. Compared to retinal gene therapy, muscle gene therapy faces a number of unique challenges. Muscle is one of the most abundant tissues in the body. An effective therapy will require systemic ... components regulating muscle- specific genes have been identified and partially characterized. The muscle creatine kinase (MCK) gene has served as a useful model of muscl...

Ngày tải lên: 29/06/2014, 09:20

... diseases for AAV gene therapy approachesFigure 3 Target diseases for AAV gene therapy approaches. Publications on AAV-based gene therapy per areaFigure 2 Publications on AAV-based gene therapy per ... Eur J Hum Genet 2004, 12:263-271. 20. Pfeifer A, Verma IM: Gene therapy: promises and problems. Annu Rev Genomics Hum Genet 2001, 2:177-211. 21. Worgall S: A realistic chance...

Ngày tải lên: 20/06/2014, 01:20

... Thus, the use of gene therapy may be a new way to treat CCRCC. In the field of cancer gene therapy, it is well known that the success of therapy is greatly dependent on t he gene delivery vectors ... and does not sensitive to radiotherapy and chemotherapy [2,3]. There- fore, a no vel therapy strategy against CCRCC needs to be developed. In the past decade, gene therapy was st...

Ngày tải lên: 18/06/2014, 19:20

... effectively co- operate with HRP/IAA gene therapy. Another major focus of the present study was to evaluate whether sui- cide gene therapy plus immuno -gene therapy had any toxicity on the treated ... of a therapeutic gene to cancer cells. Gene directed enzyme/prodrug therapy (GDEPT) or suicide gene therapy using viral vectors is an attracti ve alternative approach to canc...

Ngày tải lên: 20/06/2014, 03:20

... viral vectors for gene therapy. Nat Rev Genet 2003, 4:346-358. 103. Edelstein ML, Abedi MR, Wixon J, Edelstein RM: Gene therapy clin- ical trials worldwide 1989–2004-an overview. J Gene Med 2004, 6:597-602. 104. ... gene (TUTR1): a novel gene in human tumorigenesis. Cytogenet Cell Genet 1999, 84:211-6. 13. Heaney AP, Nelson V, Fernando M, Horwitz G: Transforming events in thyroid...

Ngày tải lên: 20/06/2014, 07:20

... transplantation therapy. The ideal stem Gene Therapy Applications 26 Therapy, 2003). Progress in the field of gene therapy has been limited by safety concerns related to delivery vectors. Genetically ... Jesus K. Yamamoto-Furusho Chapter 21 Gene Therapy for Alpha-1-Antitrypsin Deficiency Diseases 375 Parveen Salahuddin Chapter 22 Recent Developments in Gene Therapy...

Ngày tải lên: 28/06/2014, 05:20

... E2b genes and the use of homologous (rat) BMP genes do not improve the osteogenic potential of direct BMP adenovirus vector gene therapy, the results of this study indicate that BMP gene therapy ... vector and to its transgene. J Immunol 1997; 159:685-93. 43. Varady P, Li JZ, Cunningham M, et al. Morphologic analysis of BMP-9 gene therapy- induced osteogenesis. Hum Gene Ther...

Ngày tải lên: 31/10/2012, 17:08

... to human germline gene therapy. 2. Criteria for Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have ... important advances in gene transfer technology. K K e e y y w w o o r r d d s s gene targeting; gene therapy; genetic modification; pronuclear microinjection; sperm-medi...

Ngày tải lên: 03/11/2012, 10:01