molecular pathology of the prions

... including the propagation of ideas. Contemporary prions are parasitic on the prion protein manufactured by the host cell, but the mechanism by which the information contained in the shape of the prion ... own agenda 10 Ridley within the cytoplasm of the cells of other organisms. This multiplicity of infor- mation replication systems is further exemplified at the...

Ngày tải lên: 11/04/2014, 06:57

... shape of the dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top of the hollow (Fig. 1A). The model structure of the ... The product of the lipase reaction, free fatty acid, was measured after the addition of ADIFAB to 4702 Y. Kobayashi et al. (Eur. J. Biochem. 269) Ó FEBS 2002 final 0....

Ngày tải lên: 21/02/2014, 15:20

... are mainly limited to the conformation of the Glu-Pro dipeptide in the hinge region between the last b-strand and the core of CKS. The crystal structure of the com- plex of CKS with CDK2 ⁄ cyclin ... whereas in the study on cyclin E degradation, Pin1 was brought in by the phospho-cyclin E and not by the CDC4a compo- nent of the final complex (Fig. 2) [35]. There...

Ngày tải lên: 07/03/2014, 05:20

... analysis of the 5 ¢ end of the xMGP promoter reveale d a minimal activating ele- ment in the s equence from )70 to )36 bp. Synthetic reporter constructs containing three c opies of the d efined ... identified 5¢ end of the xMGP cDNA [4]. The lower group of bands, identified as site ÔBÕ in Fig. 4, probably corresponds to a premature arrest of the reverse transcriptase du...

Ngày tải lên: 08/03/2014, 10:20

... to that of Gly312 in the pig enzyme. On the other hand, the Leu residue present in the horse and yeast enzymes is conserved in the majority of PGK sequences reported to date; however, in the EhPGK, ... residue (Fig. 2A). The presence of the shorter lateral chain of Val as the only evident change in the purine-binding pocket site of the EhPGK suggested that it c...

Ngày tải lên: 16/03/2014, 01:20

... which the majority of the protein motion is defined [27,28]. The analysis is based on the diagonalization of the covariance matrix built from the atomic fluctuations after the removal of the A B Fig. ... that defines the surface of the gap region [26]. In the interior of the HPV-16 b-barrel, at the inter- face of each dimer, only one small cavity, present fo...

Ngày tải lên: 16/03/2014, 10:20

... is the detection of the modification, which involves the detection of a molecular mass change of 1 Da in a relatively large protein substrate (20–45 kDa). Another challenge is the development of ... to that of PMT-C3 is that, at the sequence level, there is no discernible similarity of PMT-C3 to the proteins, with the exception of the Cryseobacterium protein glu...

Ngày tải lên: 22/03/2014, 15:21

... earlier, the molecular identity of the protein(s) that actually form the PTP channel remains the most intriguing question. On the basis of structural and other information, we hypothesize that the ... sensitive to ruthenium red [22], implying that it may be the Ca 2+ uniporter or part thereof. Further studies revealed a set of unique features for this preparation. One o...

Ngày tải lên: 23/03/2014, 03:20

... in the spleen of these mice. For the determination of the number of PMM56 bacteria present in the spleen of these four mice, we thus chose a value of 50 CFU per spleen. The average number of ... a position of the fatty acyl residues. The signals that correspond to the resonance of the methine proton of the a carbon (d) and that of the carbon bearing...

Ngày tải lên: 23/03/2014, 09:20

... is the predominant product of hydrolysis and increases in concentration as the reaction proceeds [21]. The exo-loop of 1CEL (amino acids 243–256) forms the roof of the active site tunnel at the ... confirmed the identity of the T. emersonii cel7 gene/gene product; the location of these peptides in the deduced polypeptide sequence is given in the legend to F ig....

Ngày tải lên: 23/03/2014, 13:20