Báo cáo khoa học: Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates pdf

... Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates Linda So ¨ derberg 1, *, Camilla Dahlqvist 1, *, ... vivo. Abbreviations Ab, amyloid b-peptide; AD, Alzheimer s disease; APP, b -amyloid precursor protein; CLAC, collagenous Alzheimer amyloid plaque component ⁄ collagen XXV; EM, electron microscopy...

Ngày tải lên: 30/03/2014, 16:20

... University, Sweden The amyloid b-peptide (Ab) is the major component of the amyloid plaques found in the extracellular com- partment in the brains of patients suffering from Alzheimer s disease. ... related to the processes leading to the aggregation and formation of fibrils in the Alzheimer plaques. Abbreviations Ab-peptide, amyloid b-peptide; PII, polyproline II. 3938 FEBS Jou...

Ngày tải lên: 20/02/2014, 01:20

... pathogenesis of Alzheimer s disease by inducing transferrin expres- sion via up-regulating its transcription. Abbreviations Ab, b -amyloid protein; AD, Alzheimer s disease; AICD, amyloid precursor ... in senile plaques of Alzheimer s disease: an index of oxidative stress. Acta Neuropathol 91 , 1–5. 16 Behl C, Davis JB, Lesley R & Schubert D (1994) Hydrogen peroxide mediates amyloid...

Ngày tải lên: 23/03/2014, 03:20

... shown that this fragment forms a rigid amyloid core [22]. New insights into the components that mediate the self-assembly of various polypeptides into amyloid fibrils will help to answer questions ... by Alzheimer disease amyloid beta-protein [A beta P-(1–40)] in bilayer membranes. Proc Natl Acad Sci USA 90, 10573–10577. 16 Arispe N, Rojas E & Pollard HB (1993) Alzheimer...

Ngày tải lên: 23/03/2014, 07:20

... The neighboring chromatosomes are connected by linker DNA. The linear array of nucleosomes folds into 30 nm fiber, the second level of chromatin organization. The linker histones and the core histone ... chromatin fibers have illustrated the complexity of the process and the key role of certain specific components. Nevertheless a substantial disparity exists in the data reported from various e...

Ngày tải lên: 14/02/2014, 18:20

... the hydrophilic translocator is the only component that is neither directly, nor indirectly asso- ciated with the target membrane; rather, it assembles into a distinct structure at the tip of ... encoded within the lcrGVHyopBD genetic element). Translocon components are dispensable for secretion but are essential for the injection of type III effectors into the target cytoplasm and th...

Ngày tải lên: 14/02/2014, 22:20

... hoan thien ve the chat va tam hdn. Hdi nghi 'Nghien danh gia ket qua bi/oc 1 de tai khoa hoc cap tinh cuu tieng dia phuong Thanh Hoa" (thang 5/2010)

Ngày tải lên: 18/02/2014, 05:20

... it should be taken into account that the purified RPE65 in the assay was not completely bound to liposomes and, furthermore, liposome-bound RPE65 may be incompletely refolded into its active conformation. ... isomerohydrolase activity. Furthermore, we found that all-trans-retinyl ester must be incorporated into the phos- pholipid membrane to serve as a substrate for isomerohydrolase. Thi...

Ngày tải lên: 18/02/2014, 08:20

... GTP is converted into 2,5-diamino-6-ribosylamino-4(3H)-pyri- midinone 5¢-phosphate (2) by the catalytic action of GTP cyclohydrolase II (Fig. 1) [7]. The product is transformed into 5-amino-6-ribitylamino-2,4(1H,3H)- pyrimidinedione ... been subjected to mutagenesis). The resulting, mutated genes were ligated into the expression plasmid pQE60 and transformed into an Escherichia coli s...

Ngày tải lên: 18/02/2014, 11:20

... inductive transcriptional regulatory responses, and studies on HSF1 have yielded important insights into basic cellular and molecular biology and contributed to drug discovery [2–4]. As transcriptional ... incubated with biotin-labeled probe containing HSE. Aliquots of binding reactions are pipetted into a 384-well plate, and acceptor beads containing antibody against HSF1 are added to th...

Ngày tải lên: 18/02/2014, 14:20