Báo cáo khoa học: Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1a ppt

... FEBS Inhibitor of nuclear factor- kappaB alpha derepresses hypoxia- inducible factor- 1 during moderate hypoxia by sequestering factor inhibiting hypoxia- inducible factor from hypoxia- inducible factor ... FIH, factor inhibiting hypoxia- inducible factor; GFP, green fluorescent protein; HA, hemagglutinin; HIF, hypoxia- inducible factor...

Ngày tải lên: 29/03/2014, 23:20

... terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. ... of approximately 250 kDa, and that transition of subunits from this complex to the mature holoenzyme had stalled in the mitochondria of patients with isolated complex IV deficiency....

Ngày tải lên: 07/03/2014, 00:20

... changed by any of the four types of CRLPs. Effect of the fatty acid composition of CRLPs on COX-2 mRNA expression The effect of CRLPs of varying fatty acid composition on expression of COX-2, ... transcription factor nuclear factor- jB (NF-jB) has been implicated. In this study, the influence of CMR on the activity of NF-jB in macrophages and its modulation by the fa...

Ngày tải lên: 23/03/2014, 04:20

... composed of palin- dromic repeats of a hexanucleotide sequence separated by three non-conserved base pairs with each HRE half-site being bound by one receptor monomer [12,13]. Out of the multitude of ... cell-type-specific pattern of histone modifications. Identification of enhancer elements has not been an easy undertaking because of their distant localization from regulated...

Ngày tải lên: 28/03/2014, 22:21

... RNA before addition of the antibody. The effective- ness of this treatment was determined by examining the absence of intact rRNA by gel electrophoresis of RNA samples prepared from the treated ... HSP27 during recovery from heat shock. This process perhaps facilitates refolding of eIF4G into its native form during recovery from heat shock. We propose that PABP1 associ...

Ngày tải lên: 18/02/2014, 12:20

... DH m is the enthalpy change of unfolding at T m calculated by van’t Hoff analysis. The difference between the free energy change of unfolding of the mutant protein and that of the wild- type protein ... Areas ‘Systems Genomics’ from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and by an Industrial Tech- nology Research Grant Program from th...

Ngày tải lên: 18/02/2014, 13:20

... controls removal of phos- phate from Y17 of CDK4. The increase in Y17 phosphorylation brought about by TGFb corresponds to a loss of CDC25A [14], and an increase in Y17 phosphorylation of CDK4 has ... appearance of kinase activity in those samples. The level of depletion of kinase activity mirrored the level of depletion of C-YES, indicating that C-YES contributes a larg...

Ngày tải lên: 18/02/2014, 18:20

... < 50% of the IgE-binding activity of that of the natural allergen. Expression of Der p 1 in the yeast Saccharomyces cerevisiae revealed high IgE reactivity, although clear differences from the ... vitro histamine-release assays White b lood cells were isolated from blood of a nonallergic donor by Percoll c entrifugation and stripped from IgE by lactic acid treatment a s...

Ngày tải lên: 17/03/2014, 11:20

... stabilized by an unfolded sulfatase polypeptide, which might explain the regulatory function of pFGE. Alternatively, the inhibitory effect of pFGE observed on FGE function could be indirect, namely by ... processing of its N-glycan in the secretory pathway [23]. Treatment with up to 8 ngÆmL )1 doxycy- cline for 28 h led to expression of pFGE ranging from 0.34 to 6.1 lg of pFGE...

Ngày tải lên: 23/03/2014, 07:20

... level, a major breakthrough for the understanding of oxygen sensing was the discovery of hypoxia- inducible factor 1a (HIF -1a) [1], which, during hypoxia, activates at least 60 genes involved in ... response factor 1; EMSA, electrophoretic mobility shift assay; HIF -1a, hypoxia- inducible factor 1a; ORE, oxygen responsive element; OREF, ORE binding factor; RACE, rapid...

Ngày tải lên: 30/03/2014, 03:20