... discovery of a brain-specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularlywithin the injured or diseased brain. In the ... examining the role of GIF in AD, linked to its initial discovery as a factordeficient in the AD brain. There remains no clear con-sensus on the role of GIF in the pathogenesis of AD, and therefore ... have investigated whether GIFacts in a neuroinhibitory manner when administereddirectly into the brain following traumatic brain injury. In one such study, the injection of GIF into the site of a...