... example, inthe case of questionQ209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor. ... mountain; (b) lava IS-PART of vol-cano, and moreover it is a part coming from the inside; and (c) fragments of lava have all the prop-erties of lava, the following question semantic The Roleof ... “Where did the ukulele originate ?”, the expected answer type isLOCATION. Inthe paragraph the ukulele intro-duced from Portugal into the Hawaiian islands”contains two named entities ofthe category...
... documents and find that the fea-ture vectors corresponding to some of these docu-ments (particularly the short ones) have all zeroes in them. In other words, none ofthe bigrams from the training set ... cap-turing two different situations, one in which the author himself likes the movie, and inthe other, the author’s cousin likes the movie. The over-generalization resulting from these “stemmed” ... rating of ≤ 2 (out of 5)or ≤ 1.5 (out of 4).614Finally, previous work has also investigated fea-tures that do not fall into any ofthe above cate-gories. For instance, instead of representing...
... awell-defined hyperintensity mass inthe cervical area. The shape of the uterine cervix is distorted inthe DWI (arrowhead). d On the ADC map the tumor is hypointense (arrow) and the normal ... imaging technique (SENSE factor of 2). Imaging time of DWI was 90 s for 20 slices.Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue. On the other ... with uterine leiomyomas and ableeding cyst. a Axial T2-WI shows an area of hypointensity in the center ofthe cystic component (arrow). b On T1-WI with fatsuppression the area inthe cystic...
... of PKA inthe mitochondrial targeting of CYP2E1 The roleof PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. The first approach involved measuring the level of mito-chondrial ... microsomes requires the co-translational insertion ofthe newly synthesized proteininto the microsomal membrane, where the N-terminalhydrophobic signal sequence ofthe protein interactswith a ... mitochondria-targeting signal in the yeast system.Mitochondrial localization of intact CYP2E1 in yeast cellsBecause ofthe existing ambiguity inthe literature on the nature and extent of CYP2E1 import into...
... providedfurther insight into the molecular mechanism driving the formation ofthe covalent C115–fosfomycin adduct. Aconservative exchange of K22 to arginine maintains fosfo-mycin binding, while ... form ofthe protein. The results obtained with the K22V/R120K doublemutant protein point toward a central roleof arginine 120 in the conformational process occurring during catalysis.Therefore, ... Lysine 22 and arginine 120 in MurA (Eur. J. Biochem. 271) 2685 the positively charged side chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin...
... UniversityRegional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... UniversitySmall Business Initiative inthe Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new businessIndirect Contributions ... $28,000 in average annual salary)Preserving ValueContinuing education is important to preserving the market value of specialized education – particularly in professional fieldsContinuing education...
... dependence ofthe pH-activity curve of API The pH-activity profiles depending on NaCl concentrationwere determined as part ofthe investigation into the shielding from solvent ofthe electrostatic interactionbetween ... position. Inthe struc-tural deviation, the solvent ASA ofthe side-chain of His210increased with the decrease in size ofthe side-chain atresidue 169 (Table 1 and Fig. 3A). However, the ASAs of Asp113 ... size ofthe side-chain at residue 169 and the pK2showed a clear linear relationship (Fig. 3B). The pK2increased as the size ofthe residue at position 169 increased. The effect ofthe size of...
... designed on the basis of side-chain packing criteriafrom a modelled structure ofthe enzyme resulted in restor-ation ofthe energy of activation to the levels ofthe nativeenzyme and in an increased ... flexibility limits the exploitation ofthe fullpotential of protein engineering inthe redesign of psychro-philic enzyme properties [15]. In particular, the effects of local flexibility in psychrophilic ... respectively. By introducing an Ala residue inthe place of Gly it is expected that the conformational flexibility of the main chain can be constrained with a minimum perturba-tion ofthe local structure,...
... by the C domain ofthe initiation module of dapto-mycin. That DptE and DptF are involved in the lipidation process of daptomycin was first shown byMiao et al. [1]. In their work, the daptomycin ... is GLDSV,indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) orleucine (L) inthe conserved sequence. To determinewhether DptF is the putative ... [37].Interestingly, inthe case ofthe lipopeptide surfactin,neither an acyl CoASH ligase-like domain nor an ACPcould be identified within the biosynthetic gene clusterusing bioinformatic tools...
... antigen in itself [7,20]. Atleast for these antibodies, theroleofthe VLdomainmight be to increase the affinity by supporting the VHdomain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clearwhether or not H39 is dominantly tuning the VH⁄ VLinteraction of other Fvs, including HyHEL-10. In addition, the effect ofthe H39 ... clarify the effect ofthe interface mutations on the antigen-binding affinity. To investigate systematically thisunsought relationship between the antigen-bindingaffinity of Fv and the VH⁄ VLinteraction...
... their brand attitude, may suggest an interesting implication for the new brand advertising strategy. Instead of focusing on the content ofthe message which only emphasizes the benefits of ... gift giving is instrumental in maintaining social ties and serves as a mean of symbolic communication in social relationship. Most ofthe researches before and after the appearance of Sherry’s ... described in details the stages ofthe whole gift-exchange processes, researchers have examined the influence of many variables within these stages. This model divides gifting activities into...
... school. Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of attending college. Further, when net worth is included inthe model, Black youth are ... youth. Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If they had an account, they were also asked whether they were saving some of this money ... ―very concerned‖ about the cost of college, compared to 19% of high-income parents. Further, they find that 71% of low-income youth say they are very concerned about the cost of college (ACSFA,...
... that the increase of Glc6P inthe presence of S4048 was caused by the inhibition of Glc6P hydro-lysis inthe absence of detectable changes in glucosephosphorylation.S4048 causes inactivation of ... glu-cokinase and hexokinase I in distinct pools [3,24], orby the involvement of mechanisms, additional toGlc6P, in mediating the effects of glucokinase over-expression. As glucokinase binds ... control of glycolysis and glycogen synthesis by glucokinase overexpres-sion. The validity of S4048 for testing theroleof Glc6P was supported byits lack of effect on glucokinase binding and...
... tightbinding affinity was demonstrated towards lauric acid,resulting inthe synthesis of mainly x-1 hydroxylatedlauric acid, suggesting a roleinthe lipid oxidativemetabolism. Interestingly, the ... occurring in the soil. Furthermore, branched chain fatty acids make up80% ofthe fatty acid content ofthe Bacillus sp. mem-branes and when the hydroxylation of these substrateswas studied in ... enzymes. The FUM6 protein (CYP505B1) inter-venes in one ofthe first steps in fumonisin synthesis byhydroxylation ofthe polyketide-amino acid at C-14and C-15 (Fig. 3). Fum6 deletion mutants of F....
... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility. The timing ofthe appearance of interest rate swaps, coming as it did during a pe-riod of ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk. The Role for Hedging inthe Theory of Corporate ... net cost ofthe synthetic fixed-rate financing is determined by the swap fixed rate plus the difference between its short-term borrowing rate and the floating-rate index.Banks often index the short-term...