Niclosamid la d i n chat cua Salicylanilid. Thudc cd dang bot kd't tinh mau vang nhat, khong hoa tan trong nude. Thudc khong ha'p thu qua niem mac dudng tieu hoa nen dung de tay giun, san dudng tieu hoa ra't tot.
Niclosamid dupe bao che d dang bot, vien nen, vien nhong, com va nhu tuong.
Thudc Niclosamid dupe chi dinh dung dieu tri benh san day Moniezia, thudc cd hieu luc rat cao.
Lieu lupng: cho gia sue nhai lai uong mot trong cac dang bao che d tren vdi lieu 70 - 80 mg/kgTT. Tot nhat la che thudc thanh dang nhu tuong rdi cho uong ngay.
- Niclosamid - Tetramisol B
Niclosamid - Tetramisol B la mot biet dupe ket hop hai loai thudc tri ky sinh trimg dudng tieu hoa, cd tac dung tot vdi san day va cac loai giun trdn.
Thudc dupe bao che dudi dang vien to, mau vang nhat. Mdi vien cd: Niclosamid tinh khiet : 4 gam
Tetramisol hydroclorua : 940 mg
Ta dupe VD
Thudc Niclosamid - Tetramisol B cd phO hoat lire rong vdi nhieu loai san day va giun trdn ky sinh d dudng tieu hoa va dudng ho hap. Thudc dupe chi dinh dimg didu tri benh san day Moniezia, cac benh giun tron dudng tieu hoa va benh giun phdi.
Lieu lupng: 1 vien/ 75 - 80 kgTT. Cho uong. - Albendazole
Albendazole la dan xua't cua Imidazole, thuoc nhom Benzimidazole.
Thudc d dang bot mau trang, khong tan trong nude, dupe bao che dudi dang nhu tuong dau, cd kha nang dung nap tot d nhieu loai gia sue.
A lbendazole co tac dung tay san day Moniezia, giun phoi va cac giun xoan da day - ruot.
Che pham cua Albendazole la Vermitan 20% (20% Albendazole) Lieu lugng: 25 - 35 mg/kgTT. Tron thuc an cho an.
Da co nhidu cong trinh nghien curu sir dung thudc dieu tri benh san day M o n ie zia d de va be.
Phan Dich Lan va Pham Sy Lang (1975) da dieu tri benh san day cho de bang dung dich gom: Sulfat d6ng (10 gam) + nude cat (1000 ml) + HC1 ( 1 - 4 ml). Cho uong 2 - 3 ml/kgTT, dung tdi da 60 ml/de. Hieu lire tay san day dat 80%.
Mishareva T. E. (1977) da dimg Sulfat dong phoi hop vdi Phenothiazine va mudi an theo ty le 1: 10: 100, dimg hang ngay cho de de phong benh Moniezia. Tac gia con cho biet. nhirng thudc co hieu lire trong didu tri benh do Moniezia la: Albendazole (10 mg/kgTT), Fenbendazole (5mg/kgTT), Cambendazole (20 mg/kgTT), Oxyfendazole (5 mg/kgTT), Praziquantel (15 mg/kgTT), Resorantel (65 mg/kgTT), Bithionol (200 mg/kgTT), Niclosamid (75 - 150 mg/kgTT).
Dao Huu Thanh va Le Sinh Ngoan (1980) da dimg mot sd thudc tay giun san, trong do co thudc Niclomison dd tay san day va giun tron cho de.
Misra S. C. va cs (1989) da dimg thudc Albendazole lidu 7,5 mg/kgTT dung tay san day Moniezia cho bd va 5 mg/kgTT taly san day cho de. Sau khi tay, theo doi den ngay thu 50 thay phan van am tinh vdi Moniezia. Thudc khong co tac dung phu.
Nguydn The Hung (1996) da dimg Niclosamid - Tetramisol B tay san day cho dd thay co ket qua tot.
Sir dung thudc Oxfendazole, Vermitan, Niclosamid - Tetramisol B tay san day
Moniezia cho dd d tinh Thai Nguydn, Nguydn Thi Kim Lan (2000) cho biet, Oxfendazole lieu 5 m g/kgTT (cho uong) co hieu lire tay Moniezia thap (70%), ngoai ra con lam cho 5% sd de dimg thudc co phan ung phu. Thudc Vermitan 20%, lieu 35 mg/kgTT (cho uong) co hieu lire tay Moniezia dat 90% va an toan 100%. Thudc Niclosamid - Tetramisol B, lieu 66 mg/kgTT (cho uong) dat hieu lire 100% vdi Moniezia
va an toan 100% vdi dd duoc dimg thudc.
5.2. Phong benh
Phong benh M oniezia cho su e vat nhai lai bang p h u o n g p ha p p h o n g trir t o n g h op,
bao gom:
- Tay san d a y c h o s u e vat trudc khi san th anh thuc b a n g m o t trong ca c lo a i th u o ctren. D d i vdi n h u n g dan g ia su e c h a n tha tren bai c h a n da c o m a m b en h thi sau khi ch an