which are transcription factors regulating normal intestinal development

... 2010 FEBS 3379 Tyr54, Leu55 and Val56) are located in helix a3. Because this helix appears necessary for stabilizing the HTH motif, which is in itself apparently insufficient for independent folding, ... Leu36, which are buried in the dimer Interface-I. In this dimer constellation, the side chains of residues Tyr74, Phe75 and Ser76, also previ- ously shown to be important for oligomerization, are exposed ... residues, however, are buried at Interface-II. Discussion The FocB protein is a transcription factor involved in the regulation of genes for production of F1C fimbriae that are commonly expressed...

Ngày tải lên: 15/03/2014, 23:20

... regulate each other’s development. GATA3 suppresses STAT4 and the IL-12Rb2 chain expression, factors which are critical to the Th1 pathway [15], whereas IL-27 suppresses Th2 development [16]. Th17 ... compared with mammalian Foxp3. In addition, within human Foxp3, there are two other domains, not found in other Foxp subfamily members and possibly specific for T reg cell biology, which are transcriptional ... zebrafish transcription factors, T-box expressed in T cells (t-bet), signal transducer and activator of transcription 6(stat6) and fork-head box p3 (foxp3), in which two transcripts are pres- ent,...

Ngày tải lên: 16/02/2014, 09:20

... cartilage and skeletal development are well described, and several molecular factors are known to influence the events of this enchondral ossification, especially transcription factors. Members of ... in post-transcriptional processing of the protein [41]. Additionally, it is evi- dent that AP-2 transcription factors can indirectly modulate genes by functional interactions with other transcription ... been performed, analyzing the role of this transcription factor as a main regulator of facial and limb development in embryogenesis. Further analyses are required to clarify the regulatory mechanisms...

Ngày tải lên: 16/02/2014, 09:20

... reg- ulation of transcription that we will describe below [125]. Regulation of HSF activities during normal brain development Few data are currently available on the in vivo mecha- nisms regulating ... brain development We will mainly focus on HSF2, which was demon- strated to influence mouse brain development. HSF2 expression, nuclear localization and DNA-binding activity correlates with brain development HSF2 ... by transcription factor Sp1. Nucleic Acids Res 25, 1333–1338. 44 Bevilacqua A, Fiorenza MT & Mangia F (2000) A developmentally regulated GAGA box-binding factor and Sp1 are required for transcription...

Ngày tải lên: 18/02/2014, 04:20

... pathological roles in RA. Other transcription factors Other transcription factors implicated in the patho- genesis of RA are the signal transducer and activator of transcription (STAT) family of ... proliferator-activated receptors (PPARs) are such examples. Peroxisome proliferator-activated receptors are members of the nuclear hormone receptor family, the largest family of transcription factors [14]. Three ... emphasizes the importance of the NF-jB, NFAT and AP-1 tran- scription factors in RA, and therefore signaling cascades of these transcription factors are feasible targets for a comprehensive anti-RA strategy....

Ngày tải lên: 18/02/2014, 18:20

... China. 442 the linguistic conditions which are crucial for lex- ical semantic classification of verbs. We develop feature sets that combine syntactic and lexical infor- mation, which are in principle useful ... performed a wide range of experiments to identify which features are most informative in AVC. Our conclusion is that both syntactic and lex- ical information are useful for verb classification. Although ... (w  v,f ), according to each normalization method. Our experiments show that using correla- tion for normalization generally renders the best re- sults. The results reported below are obtained from using...

Ngày tải lên: 20/02/2014, 09:20

... )260 and )119 promote efficient transcription. As several consensus binding sequences for known transcription factors such as GATA, Ets, and MyoD/ E-box binding factors were present within )260/)119, ... How- ever, it remains to be identified which transcription factor of the Ets-family is involved in the regulation. The members of the Ets-family of transcription factors bind to specific purine-rich ... major transcription start site) is required for efficient transcription in gastric carcinoma cells. The sequence analysis of this segment showed the presence of several consensus sequences for transcription...

Ngày tải lên: 21/02/2014, 03:20

... combinations of B-Zip transcription factors including CREB homodimers, CREB–ATF heterodimers and dimers consisting of other ATF transcription factors. In addition, there are other structurally ... and expression of dominant negative inhibitors of transcription factors, we showed that both a CRE and AP-1 site and their cognate transcription factors, cAMP response element binding pro- tein ... promoter by the AP-1 and CREB transcription factors The AP-1 refers to the DNA binding activity specific for the palindromic sequence 5¢-TGAGTCAG-3¢. Transcription factors of the basic leucine...

Ngày tải lên: 08/03/2014, 08:20

... GATA family of transcription factors is com- posed of several factors [25]. In the lung, it has been shown that GATA-4 ⁄ GATA-5 ⁄ GATA-6 are expressed in a restricted manner. These factors participate ... (1995) Transcription factors and pattern formation in the developing lung. Am J Physiol 269, L429–L442. 18 Costa RH, Kalinichenko VV & Lim L (2001) Transcription factors in mouse lung development ... shown). Role of GATA factors in the regulation of Muc5b expression In addition to TTF-1, GATA factors and, especially, GATA-6 are important factors in lung morphogenesis and are known to regulate...

Ngày tải lên: 15/03/2014, 00:20

... conjecture for spaces which admit a uniform embed- ding into Hilbert space, Invent. Math. 139 (2000), 201–240. (Received October 18, 2001) LARGE RIEMANNIAN MANIFOLDS WHICH ARE FLEXIBLE 929 which is a homeomorphism ... M(ρ). LARGE RIEMANNIAN MANIFOLDS WHICH ARE FLEXIBLE 925 Lemma 3.7. Let r : Z → M be a retraction which is one-to-one on (Z − M) and let g :(Z, M) → (Y, M) be a CE map which is the identity over M. ... + 1 k )R-neighborhoods of the arcs. LARGE RIEMANNIAN MANIFOLDS WHICH ARE FLEXIBLE 927 will do — produces a uniformly contractible metric on k which is quasi- equivalent to cX. Since X is locally connected,...

Ngày tải lên: 22/03/2014, 15:21

... not clear which transcription factor is directly responsible for transcriptional activation, as GR allows recruitment of FoxA and C ⁄ EBP, which could be the factors interacting with the transcription machinery. ... the ubiquitously expressed glucocorticoid receptor (GR) and three accessory factors. These accessory factors are the liver-enriched transcription factors forkhead box A (FoxA) and CCAAT ⁄ enhancer-binding protein (C ... particular, it is unknown to what extent DNA accessibility to transcription factors and the sequence in which the transcription factors bind play a role. Furthermore, it remains unclear whether...

Ngày tải lên: 23/03/2014, 10:20

... chimeras are target molecules for transcription factors. In addition, we hope our results will have practical implications. The finding that DNA–PNA chimeras stably interact with NF-kB transcription factors ... histocompatibility complex (MHC) proteins, interferons and growth factors [12– 20]. In addition, transcription factors belonging to the NF-kB/Rel family are involved in the transactivation of viral genomes, ... hybrids are not recognized by RNase H [33]. In spite of these very promising results, no data on the possible recognition of double stranded PNA–DNA chimeras by transcription factors are currently...

Ngày tải lên: 24/03/2014, 04:21

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Ngày tải lên: 30/03/2014, 15:20

Ngày tải lên: 30/03/2014, 16:20